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Deborah A Eppstein, Philip L Felgner, Thomas R Gadek, Gordon H Jones, Richard B Roman: N[.omega.,(.omega.-1)-dialkyloxy]- and N-[.omega.,(.omega.-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor. Syntex, David A Lowin, Tom M Moran, January 30, 1990: US04897355 (372 worldwide citation)

This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, ...


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John S Kent, Danny H Lewis, Lynda M Sanders, Thomas R Tice: Microencapsulation of water soluble active polypeptides. Syntex, Ellen J Wise, Tom M Moran, Alan Krubiner, June 23, 1987: US04675189 (333 worldwide citation)

This invention concerns novel sustained release microcapsule compositions comprising water-soluble, hormonally active polypeptides and, optionally, a polymer hydrolysis modifying agent encapsulated in a biocompatible, biodegradable polymer.


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John S Kent: Cholesterol matrix delivery system for sustained release of macromolecules. Syntex, Ellen J Buckles, Tom M Moran, Alan M Krubiner, June 5, 1984: US04452775 (221 worldwide citation)

Delivery systems for releasing macromolecular active agents to a body site at a controlled rate for a prolonged period of time, comprising a cholesteric matrix permeable to passage of the macromolecular active agent by diffusion, are disclosed. The cholesteric matrix comprises cholesterol powder and ...


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Deborah A Eppstein, Brian B Schryver: Controlled release of macromolecular polypeptides. Syntex, Lester E Johnson, Tom M Moran, Alan M Krubiner, October 9, 1990: US04962091 (196 worldwide citation)

An active agent delivery system for the controlled administration of macromolecular polypeptides which comprises a micro-suspension of water-soluble components in a polylactide matrix.


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Deborah A Eppstein, Philip L Felgner, Thomas R Gadek, Gordon H Jones, Richard B Roman: N-(.omega.,(.omega.-1)-dialkyloxy)- and N-(.omega.,(.omega.-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor. Syntex, David A Lowin, Tom M Moran, August 7, 1990: US04946787 (161 worldwide citation)

This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, ...


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Cheng Der Yu, Ursula Bruenner: Carbonate diester solutions of PGE-type compounds. Syntex, James M Kanagy, Alan M Krubiner, Tom M Moran, May 4, 1982: US04328245 (136 worldwide citation)

Stable compositions of PGE-type compounds are achieved by dissolving those compounds in carbonate diester solvents which may contain water up to the solubility limit of the carbonate diester.


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Cheng Der Yu: Propylene glycol diester solutions of PGE-type compounds. Syntex, James M Kanagy, Tom M Moran, October 11, 1983: US04409239 (135 worldwide citation)

Stable compositions of PGE and PGE-type compounds are achieved by dissolving these compounds in propylene glycol diesters of short chain fatty acids.


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Cheng Der Yu, Ursula Bruenner: Carbonate diester solutions of PGE-type compounds. Syntex, James M Kanagy, Tom M Moran, October 18, 1983: US04410545 (133 worldwide citation)

Stable compositions of PGE-type compounds are achieved by dissolving those compounds in carbonate diester solvents which may contain water up to the solubility limit of the carbonate diester.


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Deborah A Eppstein, Philip L Felgner, Thomas R Gadek, Gordon H Jones, Richard B Roman: N-(.omega., (.omega.-1)-dialkyloxy)- and N-(.omega., (.omega.-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor. Syntex, David A Lowin, Tom M Moran, May 4, 1993: US05208036 (132 worldwide citation)

This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, ...