1
Kristina Marie Burow, Jeremy S Caldwell, Robert Charles Downs, Scott Allan Lesley, James Kevin Mainquist, Andrew J Meyer, Daniel G Sipes, Mark Richard Weselak: High throughput processing system and method of using. IRM, Timothy L Smith, Genomics Institute of the Novartis Research Foundation, June 24, 2008: US07390458 (103 worldwide citation)

Briefly, the present invention provides a system and method for high throughput processing using sample holders. The system has a plurality of work perimeters, with a rotational robot preferably associated with each work perimeter. At least one transfer station area is provided between adjacent work ...


2
Robert Charles Downs, Mark Richard Weselak: Gripper mechanism. IRM, Timothy L Smith, Christopher C Sappenfield, Quine Intellectual Property Law Group P C, July 15, 2003: US06592324 (44 worldwide citation)

A gripper apparatus for grasping an object such as a specimen holder. The gripper apparatus comprises two arms. In one embodiment the arms are pivotable, and in a second embodiment, each arm includes a pivotable member. The arms are moveably coupled to each other and are structured to grasp the obje ...


3
Ansgar Brock, Christopher M Shaw, Robert C Downs: Sample deposition method and system. Timothy L Smith, July 19, 2005: US06918309 (17 worldwide citation)

A method and system to deposit rapidly, accurately and efficiently liquid droplets onto a sample plate. A liquid from which the droplet is formed contains sample molecules, matrix molecules or a mixture of both sample and matrix molecules. A sample plate is positioned with respect to a position belo ...


4
Robert Charles Downs, Mark Richard Weselak, James Kevin Mainquist: Gripping mechanisms, apparatus, and methods. IRM, Timothy L Smith, Christopher C Sappenfield, Quine Intellectual Property Law Group P C, August 23, 2005: US06932557 (16 worldwide citation)

The present invention provides grasping mechanisms, gripper apparatus/systems, and related methods. Grasping mechanisms that include stops, support surfaces, and height adjusting surfaces to determine three translational axis positions of a grasped object are provided. In addition, grasping mechanis ...


5
James Kevin Mainquist, Robert Charles Downs, Mark Richard Weselak, Andrew J Meyer, Kristina Marie Burow, Daniel G Sipes, Jeremy Caldwell: Specimen plate lid and method of using. IRM, Timothy L Smith, March 18, 2003: US06534014 (15 worldwide citation)

The specimen plate lid is generally a block, with a cover portion and a side portion. An alignment protrusion extends from the side portion and cooperates with an alignment member of the specimen plate to assist in manually or roboticly guiding the lid onto the specimen plate. An underside surface o ...


6
Robert Charles Downs, Mark Richard Weselak, James Kevin Mainquist: Gripping mechanisms, apparatus and methods. IRM, Timothy L Smith Genomics Institute of the Novartis Research Foundation, September 9, 2008: US07422411 (13 worldwide citation)

The present invention provides grasping mechanisms, gripper apparatus/systems, and related methods. Grasping mechanisms that include stops, support surfaces, and height adjusting surfaces to determine three translational axis positions of a grasped object are provided. In addition, grasping mechanis ...


7
Robert Charles Downs: Method and apparatus for performing multiple processing steps on a sample in a single vessel. IRM, Timothy L Smith, Christopher C Sapponfield, Quine Intellectual Property Law Group P C, November 15, 2005: US06964867 (12 worldwide citation)

A method is provided for determining crystallization conditions for a protein, the method comprising: performing in a same fermentation apparatus 2 or more separate fermentations where each fermentation comprises cells expressing a protein to be purified and has a fermentation volume of less than 50 ...


8
Robert C Downs, Mark R Weselak: Massively parallel fluid dispensing systems and methods. IRM, Timothy L Smith, Christopher C Sappenfield, Quine Intellectual Property Law Group P C, December 7, 2004: US06827113 (11 worldwide citation)

The present invention provides highly automated fluid delivery systems and related methods with significantly improved throughput relative to preexisting technologies. In particular, the invention relates to a fluid dispensing system that simultaneously produces multiple fluid mixtures on-the-fly in ...


9
Mark R Weselak, Brad Backes, Jared Ek: Systems and methods for sorting samples. IRM, Timothy L Smith, Genomics Institute of the Novartis Research Foundation, April 29, 2008: US07364907 (9 worldwide citation)

Methods and systems for sorting compounds and compound holders into batches for subsequent processing are provided.


10
Robert C Downs, Mark R Weselak: Method and apparatus for dispensing low nanoliter volumes of liquid while minimizing waste. IRM, Timothy L Smith, Hugh Wang, Mitchell P Brook, March 23, 2004: US06709872 (8 worldwide citation)

There is provided a method and apparatus for aspirating a volume of liquid into a syringe from a sample of the liquid. A substantial portion of the liquid in the syringe is subsequently dispensed from the syringe and returned to the sample. Accordingly, a small portion of the aspirated liquid is ret ...