Alain F Carpentier, Ernest Lane: Supported bioprosthetic heart valve with compliant orifice ring. American Hospital Supply Corporation, Tilton Fallon Lungmus & Chestnut, August 15, 1978: US04106129 (568 worldwide citation)

A supported bioprosthetic heart valve in which the supporting stent is capable of annular deformation and also of limited perimetric expansion and contraction during heart operation. The stent includes a wire frame composed of a single flexible wire preformed to define inverted U-shaped commissure s ...

Andrew H Cragg: Intraluminal stent. EndoTech, Tilton Fallon Lungmus & Chestnut, April 11, 1995: US05405377 (541 worldwide citation)

An intraluminal stent includes a continuous helix of zig-zag wire and loops which connect adjacent apices of the wire. The stent is compressible and self-expandable substantially to a pre-compressed configuration. A method of forming the stent includes bending a length of wire into a zig-zag configu ...

Robert S Schwartz, Ronald R Pfister: Medical instrument for locating and removing occlusive objects. American Hospital Supply Corporation, Tilton Fallon Lungmus Chestnut & Hill, September 6, 1977: US04046150 (303 worldwide citation)

An instrument particularly useful for locating and removing ureteral calculi and other occlusive objects from body passages. The instrument includes a flexible tube or sheath which slidably receives a tightly-twisted multi-stranded cable of a length greater than that of the tube, the cable having an ...

George J Picha: Biological implant with textured surface. Tilton Fallon Lungmus & Chestnut, March 26, 1991: US05002572 (280 worldwide citation)

An implant for soft tisse (e.g., subcutaneous, perivascular, adipose), particularly a mass transfer device having a fluid diffusing or transmitting surface in contact with the soft tissue, in which the surface of the device in tissue contact is textured to provide a regular pattern of micropillars a ...

Steven B Feinstein: Contrast agents for ultrasonic imaging. Tilton Fallon Lungmus & Chestnut, January 12, 1988: US04718433 (239 worldwide citation)

A method of ultrasonic imaging for use in medical procedures is disclosed. The method comprises providing specifically defined microbubbles formed by sonicating a bicompatible liquid comprising a sonicated aqueous protein solution, preferably a 5% solution of human serum albumin, and denaturing the ...

Steven B Feinstein: Ultrasonic imaging agent and method of preparation. Tilton Fallon Lungmus & Chestnut, October 4, 1988: US04774958 (221 worldwide citation)

An ultrasonic imaging agent is formed by subjecting an aqueous protein solution to high frequency sonication while heating the solution sufficiently to denature portions of the protein, thereby forming a dispersion of microbubbles stabilized by denatured protein. In a preferred embodiment, the prote ...

Kenneth J Widder, Peter J Westkaemper: Concentrated stabilized microbubble-type ultrasonic imaging agent. Molecular Biosystems, Tilton Fallon Lungmus & Chestnut, July 4, 1989: US04844882 (212 worldwide citation)

A microbubble-type ultrasonic imaging agent is provided comprising a parenterally-administerable aqueous medium containing a dispersion of microspheres predominantly of diameters less than 10 microns, wherein the microspheres consist of gas microbubbles encapsulated with water-insolubilized biocompa ...

David Cerny, Gary J Mills, Peter J Westkaemper: Continuous sonication method for preparing protein encapsulated microbubbles. Molecular Biosystems, Tilton Fallon Lungmus & Chestnut, September 18, 1990: US04957656 (192 worldwide citation)

An ultrasonic imaging agent is produced by a continuous sonication processing of an aqueous solution of heat-denaturable biocompatible protein. The solution is carefully preheated to a temperature of incipient protein denaturation without forming insolubilized protein. A gaseous fluid, preferably ai ...

Robert L Letsinger: Cholesteryl modified oligonucleotides. Northwestern University, Tilton Fallon Lungmus & Chestnut, September 18, 1990: US04958013 (171 worldwide citation)

Oligonucleotides modified at their backbones by the attachment of cholesteryl are described. The modified oligonucleotides anchor in the cell membrane to serve as a probe and to provide therapeutic activity.

Francis C Moore, Leon R Perkinson: Hydrogen peroxide vapor sterilization method. Moore Perk Corporation, Tilton Fallon Lungmus & Chestnut, September 25, 1979: US04169123 (152 worldwide citation)

A method of sterilizing the surfaces of articles such as medical intruments and other products by exposing such surfaces to hydrogen peroxide gas at temperatures below 80.degree. C. in a temperature range that is generally considered nonsporicidal.