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Sylvain Cottens, Richard Sedrani: O-alkylated rapamycin derivatives and their use, particularly as immunosuppressants. Sandoz, Robert S Honor, Melvyn M Kassenoff, Thomas O McGovern, September 9, 1997: US05665772 (99 worldwide citation)

Novel derivatives of rapamycin, particularly 9-deoxorapamycins, 26-dihydro-rapamycins, and 40-0-substituted and 28,40-0,0-di-substituted rapamycins, are found to have pharmaceutical utility, particularly as an immunosuppressants.


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Eugen Harri, Artur Ruegger: Organic compounds. Sandoz, Gerald D Sharkin, Robert S Honor, Thomas O McGovern, September 26, 1978: US04117118 (71 worldwide citation)

This invention provides new antibiotics produced by cultivating a strain of the fungus species, Cylindrocarpon lucidum Booth or Tolypocladium inflatum Gams in contact with a nutrient medium, the antibiotics being useful anti-inflammatory and immunosuppressive agents.


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Artur Ruegger, Max Kuhn: Dihydrocyclosporin C. Sandoz, Gerald D Sharkin, Robert S Honor, Thomas O McGovern, August 22, 1978: US04108985 (60 worldwide citation)

The present invention provides dihydrocyclosporin C of formula, ##STR1## useful as an immunosuppressive.


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Rene P Traber, Max Kuhn, Hans Hofmann, Eugen Harri: Organic compounds. Sandoz, Gerald D Sharkin, Robert S Honor, Thomas O McGovern, September 2, 1980: US04220641 (55 worldwide citation)

The present invention relates to cyclosporin derivatives, especially compounds of formula I ##STR1## wherein A is ##STR2## useful as anti-arthritic agents.


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Pietro Bollinger, Johann J Bolsterli, Hans Kobel: Novel cyclosporins. Sandoz, Gerald D Sharkin, Robert S Honor, Thomas O McGovern, May 24, 1983: US04384996 (54 worldwide citation)

Novel cyclosporins having an -Allylgly- residue in the 2-position and/or a -(D)-Ser- residue in the 8-position and process for their production. The novel cyclosporins are useful as pharmaceuticals, e.g. as immunosuppressive and anti-inflammatory agents.


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Marcel K Eberle: 0-hydroxyethyl and acyloxyethyl derivatives of [ser].sup.8 cyclosporins. Sandoz, Robert S Honor, Melvyn M Kassenoff, Thomas O McGovern, February 8, 1994: US05284826 (54 worldwide citation)

Hydroxy-substituted [(D)Ser].sup.8 -Ciclosporin derivatives, particularly [O-(2-hydroxyethyl)(D)Ser].sup.8 -Ciclosporin, have advantageous pharmacological properties and are useful as immunosuppressants, for example in the treatment of transplant rejection and autoimmune diseases.


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Dieter Seebach: Novel cyclosporins. Sandoz, Gerald D Sharkin, Robert S Honor, Thomas O McGovern, September 13, 1988: US04771122 (54 worldwide citation)

Cylosporins e.g. of formula II ##STR1## in which X is -MeBmt- or -dihydro-MeBmt- and


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Roland Wenger: Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production. Sandoz, Gerald D Sharkin, Robert S Honor, Thomas O McGovern, August 2, 1983: US04396542 (48 worldwide citation)

A method for the total synthesis of cyclosporins, in particular Cyclosporin A, cyclosporins produced in accordance with the method of the invention and novel intermediates, in particular novel [1S, 2R, 3R]- and [1R, 2S, 3S]-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes, employed in t ...


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