1
Roger DiPaolo
Nathan K Weiner, Patrick J Odoy, Erik Schultz, Mark Jones, James Overbeck, Herman Deweerd, David A Stura, Albert Bukys, Tim Woolaver, Thomas P Regan, David Bradbury, Eric Earl McKenzie, Roger DiPaolo, Christopher Miles, Joel Katz, Ksenia Oleink Ovod: System, method, and product for scanning of biological materials. Affymetrix, Thomas J Siepmann, March 30, 2010: US07689022 (31 worldwide citation)

An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical el ...


2
Roger DiPaolo
Nathan K Weiner, Patrick J Odoy, Eric Schultz, Mark Jones, James Overbeck, Herman Deweerd, David A Stura, Albert Bukys, Tim Woolaver, Thomas P Regan, David Bradbury, Eric Earl McKenzie, Roger DiPaolo, Christopher Miles, Joel M Katz, Ksenia Oleink Ovod: System, method, and product for scanning of biological materials. Affymetrix, Thomas J Siepmann, January 18, 2011: US07871812 (6 worldwide citation)

An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical el ...


3
Roger DiPaolo
Nathan K Weiner, Patrick J Odoy, Eric Schultz, Mark Jones, James Overbeck, Herman Deweerd, David A Stura, Albert Bukys, Tim Woolaver, Thomas P Regan, David Bradbury, Eric Earl McKenzie, Roger DiPaolo, Christopher Miles, Joel M Katz, Ksenia Oleink Ovod: System, method, and product for scanning of biological materials. Affymetrix, Thomas J Siepmann, July 19, 2011: US07983467 (2 worldwide citation)

An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical el ...


4
Roger DiPaolo
Nathan K Weiner, Patrick J Odoy, Eric Schultz, Mark Jones, James T Overbeck, Herman DeWeerd, David A Stura, Albert K Bukys, Tim J Woolaver, Thomas P Regan, David Bradbury, Eric E McKenzie, Roger DiPaolo, Christopher Miles, Joel M Katz, Ksenia Oleinik Ovod: System, method, and product for scanning of biological materials. Affymetrix, Thomas J Siepmann, June 26, 2012: US08208710 (1 worldwide citation)

An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical el ...


5
Yanxiang Cao, Shivani Nautiyal, Charles G Miyada, Christopher Davies, Gangwu Mei, Alan J Williams, Eric B Schell, John E Blume: Analysis of methylation using nucleic acid arrays. Affymetrix, Thomas J Siepmann, March 8, 2011: US07901882 (3 worldwide citation)

Arrays for genome-wide analysis of methylation are disclosed. In a preferred aspect arrays comprising a plurality of probes complementary to a plurality of identified CpG islands in the human, mouse and rat genome are disclosed. The arrays may be used to detect methylation within CpG islands in samp ...


6
Xianqiang Li, Xin Jiang: Screening methods involving the detection of short-lived proteins. Panomics, Quine Intellectual Property Law Group P C, Monica Elrod Erickson, Thomas J Siepmann, September 7, 2010: US07790378 (2 worldwide citation)

A method is provided for screening for agents that affect protein degradation rates, the method comprising: taking a library of cells, the cells expressing a fusion protein comprising a reporter protein and a protein encoded by a sequence from a cDNA library derived from a sample of cells, the seque ...


7
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin, Douglas N Modlin: Combinatorial strategies for polymer synthesis. Affymetrix, Thomas J Siepmann, June 15, 2010: US07736906 (1 worldwide citation)

A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rota ...


8
Shantanu V Kaushikkar, Luis Jevons: System, method, and computer software product for linked window interfaces. Affymetrix, Thomas J Siepmann, August 2, 2011: US07992098 (1 worldwide citation)

Systems, methods, and computer program products are described for providing a graphical user interface (GUI) that may include a first openable window of image features constituting, for example, a pseudo-image of a scanned probe array. The image features each have one or more characteristics represe ...


9
Alan Williams, Simon Cawley, John E Blume, Hui Wang, Tyson Clark: Methods and computer software for detecting splice variants. Affymetrix, Sandra E Wells, Thomas J Siepmann, Steven M Yee, June 14, 2011: US07962291 (1 worldwide citation)

Methods and software products for analysis of alternative splicing are disclosed. In general the methods involve normalizing probe set or exon intensity to an expression level measurement of the gene. The methods may be used to identify tissue-specific alternative splicing events.


10
Akim F Lennhoff, Nathan K Weiner: System, method, and product for multiple wavelength detection using single source excitation. Affymetrix, Thomas J Siepmann, March 23, 2010: US07682782 (1 worldwide citation)

An embodiment of a method for adjusting system gain of a biological probe array scanner for a plurality of fluorophore species is described that comprises setting an excitation beam comprising an excitation wavelength at a first power level that elicits an optimal signal to noise ratio response from ...