1
Eric First, M.D.
Eric R First: Application of botulinum toxin to the management of neurogenic inflammatory disorders. Thomas J Nutter McClennen & Fish Engellenner, May 16, 2000: US06063768 (160 worldwide citation)

The present invention provides a method for the use of at least one serotype or a combination of serotypes of Botulinum neurotoxin either alone or in combination with other peptides or fusion proteins, that when administered in a safe and effective amount, antagonize and therefore decrease or block ...


2
Jeffery A Williams: Tumor treatment. Proxima Therapeutics, Thomas J Nutter McClennen & Fish Engellenner, July 4, 2000: US06083148 (215 worldwide citation)

A completely implantable apparatus is provided for treatment of tissue surrounding a cavity left by surgical removal of a brain tumor. The apparatus includes an inflatable balloon constructed for placement in the cavity. A subcutaneously implantable treatment fluid receptacle is provided for receivi ...


3
Peter J Klopotek: Method and apparatus for therapeutic treatment of skin with ultrasound. Thomas J Nutter McClennen & Fish Engellenner, September 5, 2000: US06113559 (187 worldwide citation)

A method and apparatus of reducing human skin wrinkles, including applying a focused ultrasound beam to a region of human skin to stimulate or irritate a dermis layer in the region of the skin without adversely damaging an epidermis layer in the region of the skin so as to cause a change in the derm ...


4
Lincoln S Baxter, Edward L Sinofsky, Norman Farr: Phototherapy device including housing for an optical element and method of making. CardioFocus, Thomas J Nutter McClennen & Fish Engellenner, August 15, 2000: US06102905 (74 worldwide citation)

A phototherapy device which can include an optical fiber having a perfluorinated polymer outer buffer coating, and an optical element, such as a GRIN lens or a mirror, disposed at its distal end. A tubular housing encases the optical element and is thermally bonded to at least a portion of the buffe ...


5
Jeffery A Williams, Christopher H Porter, Mark A Rydell: Inflatable devices for tumor treatment. Proxima Therapeutics, Thomas J Nutter McClennen & Fish Engellenner, August 3, 1999: US05931774 (73 worldwide citation)

Implantable devices for treatment of proliferative disorders are described. In one aspect, the invention provides an implantable apparatus for treating a proliferative disorder in a patient. The device comprises a treatment fluid receptacle for receiving a treatment fluid, an inflatable balloon havi ...


6
Joseph R Madsen: Subdural electrode arrays for monitoring cortical electrical activity. Children s Medical Center Corporation, Thomas J Nutter McClennen & Fish Engellenner, July 18, 2000: US06091979 (59 worldwide citation)

Electrodes arrays for monitoring in vivo electrical activity are disclosed. The arrays include a plurality of electrode contact pads in a predetermined spatial orientation held together by a structural matrix material that is preferably bioresorbable. The electrode pads are connected via lead wires ...


7
Peter J Klopotek: Surgical microtomes. Summit Technology, Thomas J Nutter McClennen & Fish Engellenner, August 8, 2000: US06099541 (57 worldwide citation)

Methods and apparatus are disclosed for removal of biological tissue slices or layers, preferably in the form of lamellar sections of predetermined shape and thickness employing a reference member that engages a target tissue site and cooperates with a cutter in order to remove the tissue segment or ...


8
Marc Peuker, Mathias Bertl, Dieter Poschmann: Device for storing and dispensing a flowable substance. ESPE Dental, Thomas J Nutter McClennen & Fish Engellenner, August 22, 2000: US06105761 (52 worldwide citation)

A device for storing and dispensing substances, preferably small quantities of liquids, including a container formed by two sheets, interconnected by hot sealing and cooperating to form a compartment for receiving the liquid and a pocket for receiving a brush. In the area between the compartment and ...


9
Edward L Sinofsky: Phototherapeutic apparatus with diffusive tip assembly. Rare Earth Medical, Thomas J Nutter McClennen & Fish Engellenner, September 7, 1999: US05947959 (50 worldwide citation)

Methods and devices are disclosed in which a dielectric structure is operatively coupled to phototherapeutic instrument to reflect light without substantial heating. The invention is particularly useful in light diffusive tip assemblies for phototherapy that have components which increase in tempera ...


10
Philip D Henshaw, Robert F Dillon: Interferometer with air turbulence compensation. Sparta, Thomas J Nutter McClennen & Fish Engellenner, November 23, 1999: US05991033 (29 worldwide citation)

An improved interferometer measuring system that corrects for errors in the determination of the position of a measurement reflector along a measurement path due to the presence of an atmosphere (e.g. atmospheric turbulence) along the path is disclosed. The system includes a two-wavelength interfero ...