1
Felix Theeuwes, Atul D Ayer: Osmotic system having laminar arrangement for programming delivery of active agent. Alza Corporation, Paul L Sabatine, Edward L Mandell, Thomas E Ciotti, February 22, 1977: US04008719 (641 worldwide citation)

An osmotic system for delivering an agent is disclosed. The system comprises a wall surrounding a compartment and has a passageway for delivering agent from the compartment. The wall is formed of a laminae comprising a lamina consisting of a multiplicity of materials in laminar arrangement with a la ...


2
William W Angell, David L Yoon: Heart valve stent and process for preparing a stented heart valve prosthesis. William W Angell, Thomas E Ciotti, July 19, 1977: US04035849 (476 worldwide citation)

An anatomically configured stent for a tanned, expanded natural tissue heart valve, a valve prosthesis including the stent, and a process for preparing the prosthesis are disclosed. The stent comprises a frame having three struts, two of which are biased radially inwardly and the third of which is a ...


3
Felix Theeuwes: Microporous-semipermeable laminated osmotic system. Alza Corporation, Paul L Sabatine, Thomas E Ciotti, Edward L Mandell, March 17, 1981: US04256108 (450 worldwide citation)

An osmotic therapeutic system for delivering a drug is disclosed. The system comprises a drug delivery module which module comprises a rate controlling laminated wall surrounding a reservoir and has a portal for delivering drug from the system. The laminated wall comprises a semipermeable lamina in ...


4
Felix Theeuwes, Richard J Saunders, Wayne S Mefford: Process for forming outlet passageways in pills using a laser. Alza Corporation, Thomas E Ciotti, Paul L Sabatine, Edward L Mandell, May 9, 1978: US04088864 (424 worldwide citation)

A high speed process and apparatus are disclosed for forming outlet passageways of accurate, predetermined size in the walls of pills which dispense their contents by osmotically pumping said contents out said outlet passageways. The pills are moved in succession by an indexer past a passageway form ...


5
Atul D Ayer, Felix Theeuwes: Osmotic system with distribution zone for dispensing beneficial agent. Alza Corporation, Paul L Sabatine, Thomas E Ciotti, Edward L Mandell, April 29, 1980: US04200098 (415 worldwide citation)

An osmotic system is disclosed for dispensing a beneficial agent. The system comprises (1) a first wall of a semipermeable material that surrounds a compartment containing a drug formulation, and has a passageway through the wall for releasing agent from the compartment, (2) a second wall positioned ...


6
Pieter Bonsen, Patrick S Wong, Felix Theeuwes: Method of delivering drug with aid of effervescent activity generated in environment of use. Alza Corporation, Paul L Sabatine, Edward L Mandell, Thomas E Ciotti, May 5, 1981: US04265874 (410 worldwide citation)

A method is disclosed for delivering a drug substantially free of rapid precipitation from an osmotic device. The osmotic device comprises a semipermeable wall surrounding a compartment, housing (1) a drug that exhibits limited solubility under neutral and acid conditions; and (2) a compound capable ...


7
Alejandro Zaffaroni: Novel drug delivery device. Alza Corporation, Paul L Sabatine, Edward L Mandell, Thomas E Ciotti, April 6, 1976: US03948254 (339 worldwide citation)

A drug delivery device for administering a drug at a controlled rate for a prolonged period of time to produce a local or systemic physiological or pharmacological effect is comprised of a wall surrounding a reservoir containing a drug. The reservoir is formed of a solid drug carrier permeable to th ...


8
Alejandro Zaffaroni: Microporous drug delivery device. Alza Corporation, Paul L Sabatine, Edward L Mandell, Thomas E Ciotti, November 23, 1976: US03993072 (329 worldwide citation)

A drug delivery device for administering a drug at a controlled rate for a prolonged period of time to produce a local or systemic physiological or pharmacological effect is comprised of a wall surrounding a reservoir containing a drug. The reservoir is formed of a solid drug carrier permeable to th ...


9
Martin S Gerstel, Virgil A Place: Drug delivery device. Alza Corporation, Thomas E Ciotti, Paul L Sabatine, Edward L Mandell, June 22, 1976: US03964482 (325 worldwide citation)

A drug delivery device for percutaneously administering a drug comprising a plurality of projections, a drug reservoir containing a drug, and where the projections extend from the reservoir and are adapted for penetrating the stratum corneum for percutaneously administering a drug from the reservoir ...


10
Alejandro Zaffaroni: Novel drug delivery device. Alza Corporation, Thomas E Ciotti, Paul L Sabatine, Edward L Mandell, November 23, 1976: US03993073 (294 worldwide citation)

A drug delivery device for administering a drug at a controlled rate for a prolonged period of time to produce a local or systemic physiological or pharmacological effect is comprised of a wall surrounding a reservoir containing a drug. The reservoir is formed of a drug carrier permeable to the pass ...