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Shuichi Mizuno, Akihiko Kusanagi, Laurence J B Tarrant, Toshimasa Tokuno, Robert Lane Smith: Method for preparation of implantable constructs. Histogenics Corporation, Thomas C Meyers, Brown Rudnick, December 9, 2014: US08906686 (2 worldwide citation)

Neo-cartilage constructs suitable for implantation into a joint cartilage lesion in situ and a method for repair and restoration of function of injured, traumatized, aged or diseased cartilage. The construct comprises at least chondrocytes incorporated into a support matrix processed according to th ...


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B Therese Kinsella, Patrick Guiry, Helen Reid, Barry O Connor: Thromboxane receptor antagonists. UNIVERSITY COLLEGE DUBLIN NATIONAL UNIVERSITY OF IRELAND DUBLIN, Brown Rudnick, Thomas C Meyers, July 12, 2016: US09388127 (2 worldwide citation)

The invention generally relates to compounds that function as TP antagonists for treating thrombosis and other cardiovascular, renal, or pulmonary diseases. In some embodiments, the invention provides a compound including a substituted nitro phenoxy phenyl, a sulfonylurea, and an alkyl group. In som ...


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Jack D Keene, Scott A Tenenbaum, Craig C Carson: Methods for isolating and characterizing endogenous mRNA-protein (mRNP) complexes. Ribonomics, Cooley Godward Kronish, Konstantin M Linnik Esq, Thomas C Meyers Esq, March 17, 2009: US07504210 (2 worldwide citation)

Cellular mRNA-protein (mRNP) complexes are partitioned in vivo by contacting a biological sample with at least one ligand that specifically binds at least one component of a mRNP complex. Suitable biological samples comprise at least one mRNA-protein (mRNP) complex and include cell cultures, cell ex ...


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David Welford, Badr Elmaanaoui: Systems and methods for narrowing a wavelength emission of light. Volcano Corporation, Brown Rudnick, Thomas C Meyers, July 5, 2016: US09383263 (1 worldwide citation)

The present invention generally relates to methods and systems for narrowing a wavelength emission of light. In certain aspects, methods of the invention involve transmitting light through a filter and passing a portion of the filtered light through a gain chip assembly at least two times before tha ...


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Paul Hoseit, Paul Douglas Corl: Intravascular forward imaging device. VOLCANO CORPORATION, Brown Rudnick, Thomas C Meyers, November 8, 2016: US09486143 (1 worldwide citation)

The present invention generally relates to forward imaging devices for imaging the inside of a vessel and associated methods. The invention can involve an elongated body configured to fit within the vessel of a lumen and at least one imaging sensor located on the elongated body configured to image a ...


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Nathaniel J Kemp: System and method for OCT depth calibration. Volcano Corporation, Thomas C Meyers, Brown Rudnick, April 5, 2016: US09301687 (1 worldwide citation)

The invention generally relates to methods for calibrating an OCT image by comparing a detected location of a feature within the image to an expected location of the feature, calculating a calibration value, and transforming the location of pixels within the image to provide a calibrated image.


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Darren R Link, Michael Weiner, David Marran, Jonathan M Rothberg: Selection of compartmentalized screening method. Raindance Technologies, Brown Rudnick, Thomas C Meyers, March 1, 2016: US09273308 (1 worldwide citation)

The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel i ...


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Jonathan William Larson, Qun Zhong, Darren Roy Link: Digital analyte analysis. Raindance Technologies, Brown Rudnick, Thomas C Meyers, July 7, 2015: US09074242 (1 worldwide citation)

The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, e ...


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John Brian Hutchison, Jeffrey Charles Olson, Darren Roy Link: Digital analyte analysis. Raindance Technologies, Brown Rudnick, Thomas C Meyers, July 26, 2016: US09399797 (1 worldwide citation)

The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, a method for determining the nucleic acid make-up of a sample is provided.