1
Stanley N Lapidus, Philip Richard Buzby, Timothy Harris: Short cycle methods for sequencing polynucleotides. Helicos Biosciences Corporation, Thomas C Meyers Esq, Goodwin Procter, January 30, 2007: US07169560 (178 worldwide citation)

The invention provides methods for sequencing a polynucleotide comprising stopping an extension cycle in a sequence by synthesis reaction before the reaction has run to near or full completion.


2
Peter Williams, Mark A Hayes, Seth D Rose, Linda B Bloom, Linda J Reha Krantz, Vincent B Pizziconi: Method of determining the nucleotide sequence of oligonucleotides and DNA molecules. Arizona Board of Regents, University of Alberta, Thomas C Meyers, Proskauer Rose, May 2, 2006: US07037687 (150 worldwide citation)

The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template syst ...


3
Timothy D Harris: Methods for increasing accuracy of nucleic acid sequencing. Helicos BioSciences Corporation, Cooley Godward Kronish, Thomas C Meyers, October 16, 2007: US07282337 (100 worldwide citation)

The invention provides methods for improving the accuracy of a sequencing-by-synthesis reaction by sequencing at least a portion of a template and at least a portion of template complementary sequence.


4
Philip Richard Buzby: Stabilizing a nucleic acid for nucleic acid sequencing. Helicos Biosciences Corporation, Thomas C Meyers, Edwards Angell Palmer & Dodge, May 22, 2007: US07220549 (84 worldwide citation)

The invention provides methods for sequencing a nucleic acid comprising stabilizing a primer/target nucleic acid duplex on a substrate. Methods of the invention generally contemplate the use of a dual-anchored primer/target nucleic acid duplex, or a stabilizing molecule in a single molecule sequenci ...


5
Kevin Ulmer: Apparatus and methods for analyzing samples. Helicos BioSciences Corporation, Cooley Godward Kronish, Thomas C Meyers Esq, October 2, 2007: US07276720 (54 worldwide citation)

The present invention relates to apparatus, systems, and methods for analyzing biological samples. The apparatus, systems, and methods can involve using a vacuum source to pull microfluidic volumes through analytical equipment, such as flow cells and the like. Additionally, the invention involves us ...


6
Stephen Quake, Emil Paskalev Kartalov: Methods and apparatuses for analyzing polynucleotide sequences. Helicos BioSciences, Cooley Godward Kronish, Thomas C Meyers Esq, Konstantin M Linnik Esq, March 10, 2009: US07501245 (45 worldwide citation)

Methods for high speed, high throughput analysis of polynucleotide sequences, and apparatuses with which to carry out the methods are provided in the invention.


7
Marek Kwiatkowski: Compounds for protecting hydroxyls and methods for their use. Helicos BioSciences Corporation, Cooley Godward Kronish, Thomas C Meyers, October 9, 2007: US07279563 (37 worldwide citation)

A hydrocarbyldithiomethyl-modified compound of the Formula: R1—O—CH2—S—S—R2 or a salt thereof wherein R1 is an organic molecule and R2 is a hydrocarbyl is useful for protecting and/or blocking hydroxyl groups in organic molecules such as nucleotides. The hydrocarbyldithiomethyl-modified compounds ca ...


8
Christopher Horvath, Laszlo O Romoda, Guenther Grabner, Herbert A Reitsamer: Methods for deploying intraocular shunts. AqueSys, Thomas C Meyers, Brown Rudnick, November 13, 2012: US08308701 (32 worldwide citation)

The present invention generally relates to methods for deploying intraocular shunts without the use of an optical apparatus that contacts an eye, such as a goniolens. In certain embodiments, methods of the invention involve inserting into an eye a deployment device configured to hold an intraocular ...


9
Michael V Doyle, Arthur D Newell, Jack H Nunberg, Thomas J White: Human IL-2 as a vaccine adjuvant. Cetus Oncology Corporation, Barbara G McClung, Thomas C Meyers, Robert P Blackburn, April 2, 1996: US05503841 (32 worldwide citation)

Methods for enhancing the immune response to vaccination in animals, including humans, comprise administering interleukin-2 (IL-2) as part of the vaccination regimen, preferably for 5 to 14 days post-vaccination. In addition, compositions for enhancing the immune response of an animal to a vaccine e ...


10
Caleb Kennedy, Gregory J Porreca: Sequence assembly. Good Start Genetics, Thomas C Meyers, June 26, 2012: US08209130 (32 worldwide citation)

The invention relates to assembly of sequence reads. The invention provides a method for identifying a mutation in a nucleic acid involving sequencing nucleic acid to generate a plurality of sequence reads. Reads are assembled to form a contig, which is aligned to a reference. Individual reads are a ...



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