1
Edwin F Ullman, Pyare Khanna, Rohan Peries: Immunoassay device. Syntex, Gerald F Swiss, Theodore J Leitereg, August 15, 1989: US04857453 (280 worldwide citation)

A device is disclosed for conducting an assay method. The device comprises a housing, means enclosed in the housing for capturing a member of a specific binding pair in a zone and for allowing liquid to be transported by capillary action away from the zone, one or more self-contained liquid reagents ...


2
Edwin F Ullman, Thomas C Goodman, Paul D Stull: Method for detection of specific nucleic acid sequences. Syntex, Theodore J Leitereg, Mark L Bosse, February 9, 1993: US05185243 (168 worldwide citation)

A method is disclosed for detecting the presence of a target nucleotide sequence in a polynucleotide. The method comprises hybridizing a first nucleotide sequence and a second nucleotide sequence to non-contiguous portions of a target nucleotide sequence, covalently attaching the first and second se ...


3
Litai Weng, David Calderhead, Pyare Khanna, Edwin F Ullman: Concentrating immunochemical test device and method. Syntex, Theodore J Leitereg, April 26, 1988: US04740468 (167 worldwide citation)

A method and device for determining the presence of an analyte in a sample suspected of containing the analyte is disclosed. The method involves contacting a test solution containing the sample and a first member of a specific binding pair with an end portion of a strip of bibulous material capable ...


4
Edwin F Ullman, Hrair Kirakossian, John S Pease, Yuri Daniloff, Daniel B Wagner: Assay method utilizing photoactivated chemiluminescent label. Snytex, Theodore J Leitereg, August 23, 1994: US05340716 (159 worldwide citation)

Methods are disclosed for determining an analyte in a medium suspected of containing the analyte. One method comprises providing (1) a medium suspected of containing the analyte, (2) a label reagent comprising a first specific binding pair (sbp) member associated with a photochemically activatable c ...


5
Geoffrey A Dafforn, Nurith Kurn, Martin Becker, Edwin F Ullman: Multiple port assay device. Syntex, Theodore J Leitereg, January 1, 1991: US04981786 (129 worldwide citation)

A device is disclosed for conducting an assay. The device comprises a housing, means enclosed in the housing for capturing a first member of a specific binding pair (sbp) in a zone and for allowing liquid to be transported by capillary action away from the zone, first means in the housing for introd ...


6
Litai Weng, Iam Gibbons: Reducing interference in ligand-receptor binding assays. Syntex, Theodore J Leitereg, April 12, 1988: US04737456 (121 worldwide citation)

A method for assaying for a ligand analyte which is a member of a specific binding pair ("sbp member") consisting of ligand and its complementary receptor is disclosed. The ligand analyte has a binding site in common with an interfering substance present in a sample suspected of containing the analy ...


7
Robert F Zuk: Assay method for whole blood samples. Syntex, Theodore J Leitereg, June 10, 1986: US04594327 (97 worldwide citation)

Methods and compositions are provided for performing an assay on whole blood samples. The method is for a determination of an analyte which is a member of a specific binding pair (sbp) consisting of ligand and homologous receptor. The method involves a binding agent for the red blood cells in such s ...


8
Nurith Kurn, Chander Bahl, Edwin F Ullman: Homogeneous assay for specific polynucleotides. Syntex, Theodore J Leitereg, September 19, 1989: US04868104 (92 worldwide citation)

A method for determining the presence of a polynucleotide analyte in a sample suspected of containing the analyte is disclosed. The method comprises combining in an assay medium the sample and first and second polynucleotide reagents complementary to the analyte. Each of the first and second reagent ...


9
S Nicholas Stiso: Chromatographic cassette. Syntex, Theodore J Leitereg, Linda J Nyari, March 12, 1991: US04999285 (91 worldwide citation)

A chromatographic device is disclosed. The device comprises in combination a housing, a strip of bibulous material non-removably confined in the housing. The strip has a length and width only slightly less than the length and width of the inner walls of the housing. The inner walls of the housing ha ...


10
Thomas C Goodman, Martin Becker, Edwin F Ullman, Samuel Rose: Amplification method for polynucleotide assays. Syntex, Theodore J Leitereg, February 19, 1991: US04994368 (90 worldwide citation)

A method is disclosed for producing multiple copies of a primary polynucleotide sequence located at the 3' terminus of a polynucleotide. The method comprises (a) forming in the presence of nucleoside triphosphates and template-dependent polynucleotide polymerase an extension of a primary polynucleot ...