1
Halland Nis, Nazare M, Lindenschmidt Andreas, Rkyek Omar, Urmann Matthias, Alonso Jorge: A transition metal catalyzed synthesis of n-aminoindoles. Sanofi Aventis, Halland Nis, Nazare M, Lindenschmidt Andreas, Rkyek Omar, Urmann Matthias, Alonso Jorge, THEN Johann, October 23, 2008: WO/2008/125207 (46 worldwide citation)

The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein R0; R1; R2; R3; R4; R5; R6; A1; A2; A3; A4, Q, T and J have the meanings indicated in the claims. The present invention provides a direct transition metal catalyzed process to a wide ...


2
Alonso Jorge, Lindenschmidt Andreas, Nazare Marc, R Kyen Omar, Urmann Mathias, Halland Nis: A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles. Sanofi Aventis, Alonso Jorge, Lindenschmidt Andreas, Nazare Marc, R Kyen Omar, Urmann Mathias, Halland Nis, THEN Johann, December 31, 2008: WO/2009/000412 (38 worldwide citation)

A regioselective metal catalyzed synthesis of benzimidazoles and azabenzimidazoles The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present inventio ...


3
Alonso Jorge, Lindenschmidt Andreas, Nazaré Marc, Halland Nis, Rkyek Omar, Urmann Matthias: A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles. Sanofi Aventis, Alonso Jorge, Lindenschmidt Andreas, Nazaré Marc, Halland Nis, Rkyek Omar, Urmann Matthias, THEN Johann, January 24, 2008: WO/2008/009348 (12 worldwide citation)

The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein RO; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct palladium catalyzed, regioselective process to a wid ...


4
Nazaré Marc, Zech Gernot, Just Melitta, Weiss Tilo, Hessler Gerhard, Kohlmann Markus: Heterocyclic pyrazole-carboxamides as p2y12 antagonists. Sanofis Aventis, Nazaré Marc, Zech Gernot, Just Melitta, Weiss Tilo, Hessler Gerhard, Kohlmann Markus, THEN Johann, July 2, 2009: WO/2009/080226 (11 worldwide citation)

The present invention relates to compounds of the formula I, wherein R1; R2; Z; A; B; D; Q; J; V; G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong anti-aggregating effect on platelets and thus an ...


5
Nazaré Marc, Zech Gernot, Goerlitzer Jochen, Just Melitta, Weiss Tilo, Hessler Gerhard, Czechtizky Werngard, Ruf Sven: Pyrazole-carboxamide derivatives as p2y12 antagonists. Sanofi Aventis, Nazaré Marc, Zech Gernot, Goerlitzer Jochen, Just Melitta, Weiss Tilo, Hessler Gerhard, Czechtizky Werngard, Ruf Sven, THEN Johann, July 2, 2009: WO/2009/080227 (9 worldwide citation)

The present invention relates to compounds of the Formula (I), wherein R1; R2; Z; A; B; D; Q; J; V; G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong anti-aggregating effect on platelets and thus a ...


6
Alonso Jorge, Lindenschmidt Andreas, Nazaré Marc, Urmann Matthias, Halland Nis, R Kyek Omar: A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles. Sanofi Aventis, Alonso Jorge, Lindenschmidt Andreas, Nazaré Marc, Urmann Matthias, Halland Nis, R Kyek Omar, THEN Johann, December 31, 2008: WO/2009/000413 (9 worldwide citation)

The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4; Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide va ...


7
Nazare Marc, Zech Gernot, Just Melitta, Weiss Tilo, Hessler Gerhard, Czech Joerg: Quinoline-carboxamide derivatives as p2y12 antagonists. Sanofi Aventis, Nazare Marc, Zech Gernot, Just Melitta, Weiss Tilo, Hessler Gerhard, Czech Joerg, THEN Johann, October 30, 2008: WO/2008/128647 (7 worldwide citation)

The present invention relates to compounds of the Formula (I), in which R1; R2; R3; R4; R5; R6; Z; A; B; E; X; Q; J; V; G and M have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmacologically active compounds. They exhibit a strong anti-aggregating effect o ...


8
Kallus Christopher, Broenstrup Mark, Czechtizky Werngard, Evers Andreas, Follmann Markus, Halland Nis, Schreuder Herman: (De) Harnstoff- und sulfamidderivate als inhibitoren von tafia, (En) Urea and sulfamide derivatives as tafia inhibitors. Sanofi Aventis, Kallus Christopher, Broenstrup Mark, Czechtizky Werngard, Evers Andreas, Follmann Markus, Halland Nis, Schreuder Herman, THEN Johann, June 12, 2008: WO/2008/067909 (5 worldwide citation)

(EN) The invention relates to compounds of formula (I) which are inhibitors of activated thrombin-activatable fibrinolysis inhibitor. Said compounds of formula (I) are suitable for producing medicaments used for the prevention, secondary prevention, and treatment of one or several diseases associate ...


9
Heinelt Uwe, Wehner Volkmar, Hermann Matthias, Schoenafinger Karl, Steinhagen Henning: (en) Sf5 derivatives as par1 inhibitors, production thereof, and use as medicaments(de) sf5-derivate als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel. Sanofi Aventis, Heinelt Uwe, Wehner Volkmar, Hermann Matthias, Schoenafinger Karl, Steinhagen Henning, THEN Johann, August 13, 2009: WO/2009/097972 (5 worldwide citation)

(EN) The invention relates to compounds of formula (I) in which at least R1, R2, R3, R4, or R5 represents SF5. Said compounds have an antithrombotic activity and particularly inhibit protease-activated receptor 1 (PAR1). Also disclosed are methods for the production of said compounds as well as the ...


10
ROSSEN KAI: Process for the preparation of a compound useful as an inhibitor of tafia. SANOFI AVENTIS, Then Johann, November 18, 2010: WO/2010/130718 (4 worldwide citation)

The present invention relates to a process for the preparation of a compound of the formula (I), which comprises reacting a compound of the formula (IV) with an oxalic acid diester and to novel intermediate compounds used therein.