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Debra D Donaldson, Michelle Unger: MU-1, member of the cytokine receptor family. Genetics Institute, Suzanne A Sprunger, Scott A Brown, May 2, 2000: US06057128 (50 worldwide citation)

Polynucleotides encoding the MU-1 hematopoietin receptor superfamily chain and fragments thereof are disclosed. MU-1 proteins and methods for their production are also disclosed.


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William C Fanslow III, Douglas P Cerretti, Kurt M Poindexter, Roy A Black: Use of integrin antagonists to inhibit angiogenesis. Immunex Corporation, Julie K Smith, Suzanne A Sprunger, July 11, 2006: US07074408 (12 worldwide citation)

The present invention provides methods and compositions for inhibiting the biological activity of integrins, for inhibiting endothelial cell migration. and for inhibiting angiogenesis. In particular, the invention provides compositions comprising ADAM disintegrin domains and methods for using said c ...


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Kenneth Jacobs, Kerry Kelleher, McKeough Carlin, Samuel Goldman, Debra Pittman, Sha Mi, Steven Neben, Joanne Giannotti, Margaret M Golden Fleet: Polynucleotides encoding human CTLA-8 related proteins. Genetics Institute, Scott A Brown, Suzanne A Sprunger, Thomas J DesRosier, June 13, 2000: US06074849 (10 worldwide citation)

Polynucleotides encoding human CTLA-8 related proteins are disclosed. Human CTLA-8 proteins and methods for their production are also disclosed. Methods of treatment using human CTLA-8 proteins, rat CTLA-8 proteins and herpesvirus herpes CTLA-8 proteins are also provided.


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Peter R Baum, William C Fanslow III, Timothy E Lofton, Eric A Sorensen, Adel Youakim: Nectin polypeptides. Immunex Corporation, Joseph R Baker, Suzanne A Sprunger, Susan E Lingenfelter, February 13, 2007: US07175849 (5 worldwide citation)

This invention relates to nectin polypeptides and polynucleotides, to methods of making such polypeptides and polynucleotides, and to methods of using such polypeptides and polynucleotides to modulate cell adhesion, cell migration, and angiogenesis, to treat conditions related to cell adhesion inclu ...


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Timothy A Bird, David J Cosman: Human pellino polypeptides. Immunex Corporation, Suzanne A Sprunger, March 9, 2004: US06703487 (5 worldwide citation)

There are disclosed novel polypeptides referred to as Pellino polypeptides, as well as fragments thereof, including immunogenic peptides. DNAs encoding such polypeptides as well as methods of using such DNAs and polypeptides are also disclosed.


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Adel Youakim, Robert F DuBose, Steven R Wiley: Claudin polypeptides. Immunex Corporation, Suzanne A Sprunger, Susan E Lingenfelter, March 6, 2007: US07186802 (4 worldwide citation)

This invention relates to new members of the human Claudin polypeptide family, to methods of making such polypeptides, and to methods of using them to treat Claudin-associated conditions and to identify compounds that alter Claudin polypeptide activities.


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Lih Ling Lin, Jennifer Chen, Andrea R Schievella, James Graham: MADD, a TNF receptor death domain ligand protein. Genetics Institute, Scott A Brown, Suzanne A Sprunger, Thomas J DesRosier, January 27, 1998: US05712381 (3 worldwide citation)

Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand prote ...