1
Si Lok, Darrell C Conklin, Robyn L Adams, Anna C Jelmberg, Catherine E Lofton Day, Stephen R Jaspers: Testis-specific insulin homolog polypeptides. ZymoGenetics, Susan E Lingenfelter, Deborah A Sawislak, September 28, 1999: US05959075 (35 worldwide citation)

The present invention provides testis-specific insulin homolog polypeptides and polynucleotides encoding the polypeptides, as well as related compositions and methods are disclosed. The polypeptides and polynucleotides may be used within methods for enhancing viability of cryopreserved sperm, for en ...


2
Charles E Hart, Mark W Orme, Kristen M Moynihan: PDGF antagonists II. ZymoGenetics, Susan E Lingenfelter, March 24, 1998: US05731326 (20 worldwide citation)

Methods for inhibiting intimal hyperplasia in the vasculature of mammals, including primates, are disclosed. The methods comprise administering to the mammal a non-peptide PDGF antagonist such as 4-(2-(N-(2-carboxamidoindole)aminoethyl)-benzenesulfonamides or sulfonylureas. The methods are useful in ...


3
Charles R Petrie, Patricia A McKernan, Emma E Moore, John M Ostresh, Jean Philippe Meyer, Richard A Houghten, Clemencia Pinilla: Dialkyl ureas as calcitonin mimetics. ZymoGenetics, Susan E Lingenfelter, Brian J Walsh, May 21, 2002: US06391917 (18 worldwide citation)

Dialkyl urea compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. The calcitonin mimetics of the present invention are also useful in assays for the determination of calcitonin receptor activity.


4
Jiangchun Xu, John A Stolk: Ovarian tumor sequences and methods of use therefor. Corixa Corporation, Eric M Barzee, Susan E Lingenfelter, Cynthia L Shumate, September 2, 2003: US06613515 (13 worldwide citation)

Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such ...


5
Willem E Fibbe, Angelika Grossman: Methods for increasing hematopoietic cells. ZymoGenetics, Susan E Lingenfelter, January 11, 2000: US06013067 (12 worldwide citation)

Methods for increasing hematopoietic cells, including platelets and erythrocytes, in patients receiving bone marrow or peripheral blood stem cell transplants are disclosed. The methods comprise administering to a donor an amount of thrombopoietin sufficient to stimulate proliferation of cells of the ...


6
Cindy A Sprecher, Walt Kisiel, Donald C Foster: Inhibition of blood coagulation by human-kunitz-type inhibitors. ZymoGenetics, Susan E Lingenfelter, March 17, 1998: US05728674 (11 worldwide citation)

The present invention provides isolated DNA molecules comprising a DNA segment encoding novel human Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human Kunitz-type inhibitor wherein said first DNA segment is operably linked to additional DNA ...


7
Jiangchun Xu, John A Stolk: Compositions and methods for the therapy and diagnosis of ovarian cancer. Corixa Corporation, Eric M Barzee, Susan E Lingenfelter, Cynthia L Shumate, September 9, 2003: US06617109 (10 worldwide citation)

Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses ...


8
Paul O Sheppard, Jacqueline M Humes: Adipocyte-specific protein homologs. ZymoGenetics, Susan E Lingenfelter, March 6, 2001: US06197930 (10 worldwide citation)

The present invention relates to polynucleotide and polypeptide molecules for zsig39, a novel member of the family of proteins bearing a collagen-like domain and a globular domain. The polypeptides, and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in ...


9
Patricia A McKernan, Lennie Chen, Charles Petrie, James Piggott, Robert R West, Shirley Gasper, Colin Lellis: Native calcitonin mimetics. ZymoGenetics, Susan E Lingenfelter, December 16, 1997: US05698521 (7 worldwide citation)

The invention provides isolated, biologically active native calcitonin mimetics and related methods. These small 16 and 17 amino acid proteins mimic the interaction of calcitonin on its receptor, and also exhibit bone resorptive inhibiting activity.


10
Paul O Sheppard: Secreted salivary zsig32 polypeptides. ZymoGenetics, Susan E Lingenfelter, February 15, 2000: US06025197 (6 worldwide citation)

The present invention relates to polynucleotide and polypeptide molecules for secreted salivary zsig32 polypeptides. The polypeptides, and polynucleotides encoding them modulate adhesion or modulate or indicate salivary gland function. The present invention also includes antibodies and binding prote ...