1
John A Ewen: Hafnium metallocene catalyst for the polymerization of olefins. Fina Technology, John K Abokhair, Stuart L Watt, M Norwood Cheairs, December 27, 1988: US04794096 (318 worldwide citation)

The present invention provides a catalyst system for the polymerization and copolymerization of olefins with the system comprising a chiral, stereorigid hafnium metallocene catalyst in combination with an aluminum compound. The aluminum compound is preferably an alumoxane and may be a mixture of alu ...


2
John A Ewen, Abbas Razavi: Process and catalyst for producing syndiotactic polyolefins. Fina Technology, Stuart L Watt, John K Abokhair, M Norwood Cheairs, January 9, 1990: US04892851 (286 worldwide citation)

The invention provides a metallocene catalyst for use in preparing syndiotactic polyolefins. The catalyst comprises a bridged metallocene in which one of the cyclopentadienyl rings is substituted in a substantially different manner from the other ring. It was discovered that this type of catalyst is ...


3
Olaf Kinstler, Colin Gegg, Aimee Freeman, Thomas Boone: Chemically modified novel erythropoietin stimulating protein compositions and methods. Amgen, Craig A Crandall, Ron K Levy, Stuart L Watt, July 1, 2003: US06586398 (144 worldwide citation)

The present invention broadly relates to the field of protein modification, and, more specifically, the attachment of water soluble polymers to novel erythropoietin stimulating protein (NESP).


4
John A Ewen: Catalyst system for the polymerization of olefins. Fina Technology, Stuart L Watt, Jimmy D Wheelington, John K Abokhair, May 22, 1990: US04927797 (73 worldwide citation)

The present invention provides a catalyst system that exhibits unprecedented catalyst efficiencies and control of desired properties in the polymer product. The catalyst system includes a Toho-type, new generation titanium catalyst in combination with an electron donor described by the formula: ##ST ...


5
Benny C Askew, Frenel F De Morin, Andrew Hague, Ellen Laber, Aiwen Li, Gang Liu, Patricia Lopez, Rana Nomak, Vincent Santora, Christopher Tegley, Kevin Yang: Thiazolyl urea compounds and methods of uses. Amgen, Joseph W Bulock, Ron K Levy, Stuart L Watt, November 11, 2003: US06645990 (48 worldwide citation)

Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for pr ...


6
Paul Kostenuik, Chuan Fa Liu, David Lee Lacey: Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein. Amgen, Robert B Winter, Stuart L Watt, June 29, 2004: US06756480 (48 worldwide citation)

The present invention concerns therapeutic agents that modulate the activity of PTH and PTHrP. In accordance with the present invention, modulators of PTH and PTHrP comprise:


7
Thomas Wayne Strickland: Stable and preserved erythropoietin compositions. AMGEN, Stuart L Watt, Steven Odre, Ron Levy, August 26, 1997: US05661125 (40 worldwide citation)

The invention is to stable compositions of erythropoietin that contain an antimicrobial preservative thereby providing a multi-dose formulation. Preservatives useful in the pharmaceutical compositions of the present invention include benzyl alcohol, parabens, phenol and mixtures thereof. Other addit ...


8
Tracy K Blumen, Gustavo E Grampp, David J Hettwer: Methods for controlling sialic acid derivatives in recombinant glycoproteins. Amgen, Stuart L Watt, Craig A Crandall, October 17, 1995: US05459031 (31 worldwide citation)

The invention relates to the effects of certain cell culture and/or production parameters on the carbohydrate composition of a cell culture-derived recombinant glycoprotein. The methods of the invention demonstrate a practical method for controlling levels of a sialic acid derivative, NGNA, in secre ...


9
Nathan B Mantlo, Stephen T Schlachter, John A Josey: Substituted pyridine compounds and methods of use. Amgen, Frank S Ungemach, Stuart L Watt, December 25, 2001: US06333341 (22 worldwide citation)

Selected novel substituted pyridine compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically ac ...


10
Ulrike D Spohr, Michael J Malone, Nathan B Mantlo: Substituted pyrimidine compounds and methods of use. Amgen, Frank S Ungemach, Stuart L Watt, June 25, 2002: US06410729 (21 worldwide citation)

Selected novel substituted pyrimidine compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically ...