1
Michel J N Cormier, Felix T Theeuwes: Device and method for enchancing transdermal sampling. Alza Corporation, Owen J Bates, D Byron Miller, Steven F Stone, April 17, 2001: US06219574 (627 worldwide citation)

A percutaneous agent sampling device and method are provided. The device comprises a collector and a sheet having a plurality of microblades for piercing the skin for increasing transdermal flux of an agent.


2
Patrick S L Wong, Brian Barclay, Joseph C Deters, Felix Theeuwes: Osmotic device with dual thermodynamic activity. Alza Corporation, Paul L Sabatine, Edward L Mandell, Steven F Stone, September 16, 1986: US04612008 (324 worldwide citation)

An osmotic system is disclosed comprising a wall formed in at least a part of a semipermeable material that surrounds a compartment. The compartment contains a first osmotic composition comprising a beneficial agent, and a second and different osmotic composition. A passageway in the wall connects t ...


3
Robert M Gale, Victor Goetz, Eun S Lee, Lina T Taskovich, Su I Yum: Transdermal administration of fentanyl and device therefor. Alza Corporation, Steven F Stone, May 13, 1986: US04588580 (290 worldwide citation)

Transdermal delivery systems for delivery of fentanyl and its analgetically effective derivatives for extended periods of time are disclosed which deliver the base form of the drug at a rate of from 0.5 to 10 .mu.g/cm.sup.2 /hr for a substantial portion of their useful life. The systems can be from ...


4
Patricia S Campbell, Santosh K Chandrasekaran: Dosage for coadministering drug and percutaneous absorption enhancer. ALZA Corporation, Steven F Stone, Edward L Mandell, Paul L Sabatine, April 12, 1983: US04379454 (279 worldwide citation)

A dosage form that coadministers a drug and a percutaneous absorption enhancer to a defined area of the skin. The dosage form comprises a body that contains supplies of drug and enhancer and has a basal surface that contacts the area of skin and transmits the drug and enhancer to the area for absorp ...


5
John R Peery, Keith E Dionne, James B Eckenhoff, Felix A Landrau, Scott D Lautenbach, Judy A Magruder, Jeremy C Wright: Sustained delivery of leuprolide using an implantable system. Alza Corporation, Pauline A Clarke, Mary Ann Dillahunty, Steven F Stone, March 17, 1998: US05728396 (277 worldwide citation)

The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable ...


6
Michel J N Cormier, Avtar S Nat, Armand P Neukermans, Barry Block: Device for enhancing transdermal agent delivery or sampling. Alza Corporation, Owen J Bates, D Byron Miller, Steven F Stone, May 8, 2001: US06230051 (265 worldwide citation)

A percutaneous agent delivery or sampling device comprising a sheet having a plurality of microblades for piercing the skin for increasing transdermal flux of an agent. The microblades having a relatively sharp angled leading edge which transitions to a relatively gradually angled blade edge.


7
Patrick S L Wong, Brian L Barclay, Joseph C Oeters, Felix Theeuwes: Osmotic system comprising plurality of members for dispensing drug. ALZA Corporation, Paul L Sabatine, Edward L Mandell, Steven F Stone, November 8, 1988: US04783337 (237 worldwide citation)

An osmotic system is disclosed comprising a wall comprising in at least a part of a semipermeable material that surrounds a compartment. The compartment contains a first osmotic composition comprising a beneficial drug selected from the group consisting of a calcium antagonist, angiotensin enzyme in ...


8
Joseph Creagan Trautman, Michel J N Cormier, Hyunok Lynn Kim, Michael G Zuck: Device for enhancing transdermal agent flux. ALZA Corporation, D Byron Miller, Steven F Stone, July 4, 2000: US06083196 (226 worldwide citation)

A device (3) comprising a sheet member (6) having a plurality of microprotrusions (4) for penetrating the skin and a substantially incompressible agent reservoir housing (15) contacting and extending across the sheet member (6) for transmitting a hold-down force applied the sheet member (6) to maint ...


9
Harold M Leeper, Diane Nedberge, Lina T Taskovich: Skin permeation enhancer compositions. Alza Corporation, Steven F Stone, Paul L Sabatine, Edward L Mandell, February 4, 1986: US04568343 (210 worldwide citation)

A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with polyethylene glycol monolaurate. Preferred embodiments of transdermal therapeutic systems for delivering drug and polyethylene glycol mo ...


10
Patrick S L Wong, Brian L Barclay, Joseph C Deters, Felix Theeuwes: Osmotic device for administering certain drugs. Alza Corporation, Paul L Sabatine, Edward L Mandell, Steven F Stone, August 23, 1988: US04765989 (194 worldwide citation)

An osmotic system is disclosed comprising a wall comprising in at least a part of a semipermeable material that surrounds a compartment. The compartment contains an osmotic composition comprising a beneficial drug selected from the group consisting of nifedipine, prazosin and doxazosin, and a second ...