1
Peter E Daddona, Gregory T Fieldson, Avtar S Nat, Wei Qi Lin: Minimally invasive detecting device. Alza Corporation, D Byron Miller, Steve F Stone, July 18, 2000: US06091975 (776 worldwide citation)

An agent detecting device comprising a plate (6) having a plurality of microprotrusions (4) for piercing the skin of a patient. Each of the microprotrusions (4) having an electrode (14, 16 and 18) thereon for detecting the presence of an agent in the patient's interstitial fluid.


2
Gary A Lattin, Thomas A Riddle: Electrotransport system with remote telemetry link. Alza Corporation, D Byron Miller, Felissa H Cagan, Steve F Stone, September 3, 1996: US05551953 (240 worldwide citation)

An electrotransport system (20) for delivering a therapeutic agent (36) through a body surface (40) (eg, skin) of a patient includes a pair of electrodes (34, 38) for contacting the body surface, at least one of which contains the therapeutic agent (36). The system (20) is physically separated into ...


3
Judy A Magruder, James B Eckenhoff, Richard Cortese, Jeremy C Wright, John R Perry: Delivery system for beneficial agent over a broad range of rates. ALZA Corporation, Paul L Sabatine, Edward L Mandell, Steve F Stone, October 15, 1991: US05057318 (198 worldwide citation)

A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the passage of fluid into the system and a composition that permits the passage of fluid into the system. The lum ...


4
Ronald P Haak, Felix Theeuwes, J Richard Gyory, Gary A Lattin: Transdermal delivery device. Alza Corporation, D Byron Miller, Edward L Mandell, Steve F Stone, November 7, 1995: US05464387 (53 worldwide citation)

A transdermal drug delivery device (20) is provided having both an active drug reservoir (24) and a passive drug reservoir (26). Drug is actively delivered by iontophoresis from the active drug reservoir (24) by an electric field generated by a power source (21). Simultaneously, drug is delivered fr ...


5
Terry L Burkoth, Lina T Taskovich, Russell D Beste, Robert M Gale, Eun Soo Lee, Richard D Hamlin, Su LL Yum: Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate. ALZA Corporation, Michael J Rafa, Steve F Stone, December 1, 1998: US05843468 (45 worldwide citation)

Compositions, devices, and methods for transdermal administration of an active agent are disclosed using a novel dual permeation enhancer mixture comprising lauryl acetate and a monoglyceride, preferably glycerol monolaurate. The dual permeation enhancer mixture comprising lauryl acetate is a potent ...


6
Eun S Lee, Diane E Nedberge, Su I Yum: Transdermal administration of oxybutynin. ALZA Corporation, Alisa A Harbin, Steve F Stone, Edward L Mandell, May 2, 1995: US05411740 (41 worldwide citation)

The present invention is directed to the transdermal administration of oxybutynin together with a suitable permeation enhancer. The invention includes a transdermal drug delivery device comprising a matrix adapted to be placed in oxybutynin- and permeation enhancer-transmitting relation with the ski ...


7
Ronald P Haak: Electrotransport device having improved cathodic electrode assembly. Alza Corporation, D Byron Miller, Steve F Stone, Edward L Mandell, April 2, 1996: US05503632 (32 worldwide citation)

An improved cathodic iontophoresis electrode assembly (8, 38) is provided having a reducible cathodic electrode (12,22) and a drug reservoir (14, 24) containing an anionic drug. The cathodic electrode (12, 22) is separated from the drug reservoir (14, 24) by means of a layer (30) of a cation exchang ...


8
Gary A Lattin, Keith J Bernstein: Display for an electrotransport delivery device. ALZA Corporation, D Byron Miller, Steve F Stone, December 1, 1998: US05843014 (28 worldwide citation)

An electrotransport delivery device (10) with a display (14) having only on and off states, and a method of operating the display (14), are provided. Preferably, the display 14 is a light (e.g., a light emitting diode) with lit and unlit states or an audible alarm (e.g., a beeper) with sounding and ...


9
Patrick S L Wong: Osmotic device for protracted pulsatile delivery of agent. Alza Corporation, Felissa H Cagan, Steve F Stone, Edward L Mandell, March 12, 1996: US05498255 (26 worldwide citation)

The present invention is directed to a fluid-imbibing dispensing device for the extended or protracted delivery of an active agent following an initially delayed startup of the delivery to a fluid environment of use. The dispenser comprises a housing having a first wall section and a second wall sec ...


10
Darrel F Untereker, Joseph B Phipps, Gary A Lattin: Iontophorett drug delivery. Alza Corporation, D Byron Miller, Steve F Stone, Edward L Mandell, May 16, 1995: US05415628 (25 worldwide citation)

Improved methods of ionophoretic drug delivery are described. By the intentional selection of drug(s) with specific characteristics, of ionotophoresis device, components or both permits the efficiency of drug delivery is increased.