31
Hung Pin Kao, Xing Yang: Side light activated microfluid channels. Aclara Biosciences, Stephen C Macevicz, June 14, 2005: US06906797 (81 worldwide citation)

Devices are provided comprising reflecting channels for directing horizontally a vertical light beam through a multiplicity of streams. The devices provide particular applications in microfluidics, where streams of narrow cross-sectional dimensions are involved. Desirably, channels having 45° walls ...


32
Hongdong Roy Tan, Alexander Sassi, Ingrid Cruzado: Dynamic coating with linear polymer mixture for electrophoresis. Aclara Biosciences, Stephen C Macevicz, David Albagli, September 7, 2004: US06787016 (79 worldwide citation)

Compositions and methods are provided for performing capillary electrophoresis using a composition comprising in combination in an aqueous buffered medium a coating polymer and a sieving polymer, where the sieving polymer is more hydrophilic than the coating polymer and is present in greater amount. ...


33
Kevin Maher, Timothy F Smith, Torleif O Bjornson: Multiplexed fluorescent detection in microfluidic devices. Aclara Biosciences, Stephen C Macevicz, January 4, 2005: US06838680 (77 worldwide citation)

An optical detection and orientation device is provided comprising a housing having an excitation light source, an optical element for reflecting the excitation light to an aspherical lens and transmitting light emitted by a fluorophore excited by said excitation light, a focusing lens for focusing ...


34
Kenneth J Livak, Susan J A Flood, Jeffrey Mamoro, Khairuzzaman Bashar Mullah: Hybridization assay using self-quenching fluorescence probe. The Perkin Elmer Corporation, Stephen C Macevicz, David J Weitz, Vincent M Powers, July 10, 2001: US06258569 (75 worldwide citation)

Provided is a method of nucleic acid amplification. In one embodiment, the method comprises performing nucleic acid amplification on a target polynucleotide using a nucleic acid polymerase having 5′ to 3′ nuclease activity, a primer capable of hybridizing to the target polynucleotide, and an oligonu ...


35
Andreas Neyer, Matthias Jöhnck: Method for linking two plastic work pieces without using foreign matter. Aclara Biosciences, David Albagli, Stephen C Macevicz, January 4, 2005: US06838156 (74 worldwide citation)

The invention relates to a method for linking two adjacent plastic work pieces (2, 3). The inventive method is characterized in that the intended contact zone (K) of at least one of the two work pieces (2) with which the latter adjoins to the other work piece (3) is at least partially subjected to a ...


36
Torleif Ove Björnson, Laurence R Shea: Continuous form microstructure assay array. Aclara Biosciences, Stephen C Macevicz, December 7, 2004: US06827906 (69 worldwide citation)

A continuous form microstructure array device is constructed as a flexible elongate film laminate containing a plurality of microstructures or arrays of microstructures arranged serially lengthwise along the laminate. The laminate can be continuously drawn from a supply roll or stack, advanced withi ...


37
Sydney Brenner: DNA extension and analysis with rolling primers. Lynx Therapeutics, Stephen C Macevicz, July 14, 1998: US05780231 (68 worldwide citation)

A novel "primer walking" method for DNA sequencing is provided that comprises repeated cycles nucleotide identification by selective extension and primer advancement along a template by template mutation. An important feature of the invention is providing a set of primers, referred to herein as "rol ...


38
Paul D Grossman, Steven Fung, Steven M Menchen, Sam L Woo, Emily S Winn Deen: Method of DNA sequencing employing a mixed DNA-polymer chain probe. The Perkin Elmer Corporation, Stephen C Macevicz, Paul D Grossman, December 3, 1996: US05580732 (64 worldwide citation)

Method and composition for detecting one or more selected polynucleotide regions in a target polynucleotide. In the method, a mixture of sequence-specific probes are reacted with the target polynucleotide under hybridization conditions, and the hybridized probes are treated to selectively modify tho ...


39
Robert B DuBridge, Glenn Albrecht, Sydney Brenner, Sergei M Gryaznov, Sarah N McCurdy: Adaptor-based sequence analysis. Lynx Therapeutics, Stephen C Macevicz, Vincent M Powers, Joanne R Petithory, March 30, 1999: US05888737 (60 worldwide citation)

An improvement in adaptor-based sequence analysis is provided that addresses the problems created by self-ligation of target polynucleotides that have complementary ends. The improvement includes preparation of target polynucleotides with dephosphorylated 5' strands and the use of adaptors having a ...


40
Kevin Maher, Timothy F Smith, Torleif Ove Bjornson: Multiplexed fluorescent detection in microfluidic devices. Aclara Biosciences, Stephen C Macevicz, September 2, 2003: US06614030 (60 worldwide citation)

An optical detection and orientation device is provided comprising housing having an excitation light source, an optical element for reflecting the excitation light to an aspherical lens and transmitting light emitted by a fluorophore excited by said excitation light, a focussing lens for focusing t ...