21
Sydney Brenner, Glenn Albrecht, Stephen C Macevicz: Oligonucleotide tags for sorting and identification. Lynx Therapeutics, Stephen C Macevicz, May 22, 2001: US06235475 (116 worldwide citation)

The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention comprise oligonucleotides selected from a minimally cross-hybridizing set. Preferably, such oligonucleotides each ...


22
Sydney Brenner: Compositions for sorting polynucleotides. Spectragen, Stephen C Macevicz, August 5, 1997: US05654413 (111 worldwide citation)

The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention each consist of a plurality of subunits 3 to 6 nucleotides in length selected from a minimally cross-hybridizing s ...


23
Frank Lee, Takashi Yokota, Ken ichi Arai, Timothy Mosmann, Donna Rennick: Mammalian interleukin-4. Schering Corporation, Stephen C Macevicz, May 21, 1991: US05017691 (110 worldwide citation)

Mammalian proteins and muteins thereof, designated interleukin-4s (IL-4s), are provided which exhibit both B cell growth factor activity and T cell growth factor activity. Compounds of the invention include native human and murine IL-4s, muteins thereof, and nucleic acids which are effectively homol ...


24
Sydney Brenner, Glenn Albrecht, Stephen C Macevicz: Kits for sorting and identifying polynucleotides. Lynx Therapeutics, Stephen C Macevicz, November 21, 2000: US06150516 (105 worldwide citation)

The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention comprise oligonucleotides selected from a minimally cross-hybridizing set. Preferably, such oligonucleotides each ...


25
William A Andrus, Christie D McCollum, Gerald Zon: Automated system for polynucleotide synthesis and purification. Applied Biosystems, Stephen C Macevicz, November 16, 1993: US05262530 (99 worldwide citation)

A method and system for polynucleotide synthesis are provided which employ solid phase synthesis on a nonswellable porous polystyrene support by phosphoramidite or hydrogen phosphonate chemistries. The polystyrene support gives rise to fewer tritylated failure sequences caused by chain growth from e ...


26
Sydney Brenner: Oligonucleotide tags for sorting and identification. Lynx Therapeutics, Stephen C Macevicz, March 5, 2002: US06352828 (95 worldwide citation)

The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention comprise oligonucleotides selected from a minimally cross-hybridizing set. Preferably, such oligonucleotides each ...


27
Travis Boone: Efficient compound distribution in microfluidic devices. Aclara Biosciences, David Albagli, Stephen C Macevicz, November 30, 2004: US06824663 (94 worldwide citation)

Microfluidic devices are provided having units of 8-fold symmetry comprising 8 assay units, where a reservoir provides a common component to 8 assay units. The units can be compactly formed in a substrate to provide the ability to perform a large number of assays within a small area. The microfluidi ...


28
Sydney Brenner: Method, apparatus and computer program product for determining a set of non-hybridizing oligonucleotides. Lynx Therapeutics, Stephen C Macevicz, October 24, 2000: US06138077 (93 worldwide citation)

The invention provides a computerized method, associated apparatus, and computer program product for determining a set of non-hybridizing oligonucleotides. The invention represents a first oligonucleotide in the computer's memory, generates a set of oligonucleotides, including the first oligonucleot ...


29
Tomas B Hirschfeld: Remote multi-position information gathering system and method. Regents of the University of California, Stephen C Macevicz, March 18, 1986: US04577109 (93 worldwide citation)

A technique for gathering specific information from various remote locations, especially fluorimetric information characteristic of particular materials at the various locations is disclosed herein. This technique uses a single source of light disposed at still a different, central location and an o ...


30
Sydney Brenner: DNA sequencing by stepwise ligation and cleavage. Spectragen, Stephen C Macevicz, February 4, 1997: US05599675 (82 worldwide citation)

The invention provides a method of nucleic acid sequence analysis based on repeated cycles of ligation to and cleavage of probes at the terminus of a target polynucleotide. At each such cycle one or more terminal nucleotides are identified and one or more nucleotides are removed from the end of the ...