1
Sydney Brenner: Methods for sorting polynucleotides using oligonucleotide tags. Spectragen, Stephen C Macevicz, February 18, 1997: US05604097 (314 worldwide citation)

The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention each consist of a plurality of subunits 3 to 6 nucleotides in length selected from a minimally cross-hybridizing s ...


2
John Bridgham, Kevin Corcoran, George Golda, Michael C Pallas, Sydney Brenner: Planar arrays of microparticle-bound polynucleotides. Lynx Therapeutics, Stephen C Macevicz, LeeAnn Gorthey, June 18, 2002: US06406848 (233 worldwide citation)

An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of ...


3
Steven M Menchen, Linda G Lee, Charles R Connell, N Davis Hershey, Vergine Chakerian, Sam Woo, Steven Fung: 4,7-dichlorofluorescein dyes as molecular probes. Applied Biosystems, Stephen C Macevicz, Joseph H Smith, February 23, 1993: US05188934 (231 worldwide citation)

Long wavelength, narrow emission bandwidth fluorecein dyes are provided for detecting spacially overlapping target substances. The dyes comprise 4,7-dichlorofluoresceins, and particularly 1',2',7',8'-dibenzo-4,7-dichlorofluoresceins. Methods of using the dyes in automated DNA sequencing are describe ...


4
Stephen C Macevicz: DNA sequencing by parallel oligonucleotide extensions. Lynx Therapeutics, Stephen C Macevicz, Vincent M Powers, LeeAnn Gorthey, October 23, 2001: US06306597 (217 worldwide citation)

The present invention includes, in one aspect, a kit comprising one or more sets of oligonucleotide probes whose perfectly matched duplexes with complementary sequences have similar or substantially the same free energy of duplex formation.


5
Sydney Brenner, Glenn Albrecht, Stephen C Macevicz: Oligonucleotide tags for sorting and identification. Lynx Therapeutics, Stephen C Macevicz, December 8, 1998: US05846719 (214 worldwide citation)

The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention comprise oligonucleotides selected from a minimally cross-hybridizing set. Preferably, such oligonucleotides each ...


6
Sydney Br umlaut over: Oligonucleotide tags for sorting and identification. Lynx Therapeutics, Stephen C Macevicz, January 9, 2001: US06172218 (200 worldwide citation)

The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention comprise oligonucleotides selected from a minimally cross-hybridizing set. Preferably, such oligonucleotides each ...


7
Glenn Albrecht, Sydney Brenner, Robert B DuBridge, David H Lloyd, Michael C Pallas: Massively parallel signature sequencing by ligation of encoded adaptors. Lynx Therapeutics, Stephen C Macevicz, January 11, 2000: US06013445 (197 worldwide citation)

The invention provides a method of nucleic acid sequence analysis based on the ligation of one or more sets of encoded adaptors to the terminus of a target polynucleotide. Encoded adaptors whose protruding strands form perfectly matched duplexes with the complementary protruding strands of the targe ...


8
Sergei M Gryaznov, Ronald G Schultz, Jer kang Chen: Oligonucleotide N3.fwdarw.P5 phosphoramidates. Lynx Therapeutics, Stephen C Macevicz, John D Mendlein, Vincent M Powers, October 12, 1999: US05965720 (189 worldwide citation)

Modified oligonucleotides 3'-NHP(O)(O.sup.-)O-5' phosphoramidates were synthesized on a solid phase support. The phosphoramidate analogs were found to have significantly increased resistance toward phosphodiesterase digestion. Thermal dissociation experiments demonstrated that these compounds form m ...


9
Mingqi Zhao, Petr Vanysek, Antonio Ricco, Hilary S Lackritz, Zhu Qun, Uyen Nguyen, Torleif O Bjornson: Microfluidic chip having integrated electrodes. Aclara Biosciences, Stephen C Macevicz, David Albagli, September 6, 2005: US06939451 (175 worldwide citation)

A microfluidic device having integrated components for conducting chemical operations. Depending upon the desired application, the components include electrodes for manipulating charged entities, heaters, electrochemical detectors, sensors for temperature, pH, fluid flow, and other useful components ...


10
Stephen C Macevicz: DNA sequencing by parallel oligonucleotide extensions. Lynx Therapeutics, Stephen C Macevicz, Vincent M Dehlinger & Associates Powers, May 12, 1998: US05750341 (173 worldwide citation)

Method and compositions are provided for analyzing nucleic acid sequences based on repeated cycles of duplex extension along a single stranded template. Preferably, such extension starts from a duplex formed between an initializing oligonucleotide and the template. The initializing oligonucleotide i ...