1
Alan Rapacki, Michael Barrett: Bronchial flow control devices and methods of use. Emphasys Medical, Fred C Hernandez, Stephanie Seidman, Fish & Richardson P C, March 14, 2006: US07011094 (238 worldwide citation)

A flow control device includes a sealing component that can be positioned within a bronchial lumen. The sealing component can comprise two or more overlapping segments that are movable relative to one another such that the segments collectively form a seal that can expand and contract in size to fit ...


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Hubert Köster: DNA diagnostics based on mass spectrometry. Sequenom, Stephanie Seidman, Heller Ehrman White & McAuliffe, March 6, 2001: US06197498 (106 worldwide citation)

Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and sequences in the molecules are provided. Depending upon the sequence to be detected, the processes, for example, can be used to diagnose a genetic disease or a chromosomal abnormality, a pr ...


3
Franz Hillenkamp, David M Lough, G Scott Higgins, Dirk Reuter: Method and apparatus for maldi analysis. Sequenom, Stephanie Seidman, Heller Ehrman White & McAuliffe, July 23, 2002: US06423966 (97 worldwide citation)

Matrix assisted laser desorption/ionization is performed,in a manner to thermalize large analyte ions in a plume of desorbed material for spectroscopic analysis. The thermalized ions have a low or zero mean velocity and are presented at a well-defined instant in time, reducing artifacts and sharpeni ...


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Hubert Köster: Solid support for mass spectrometry. Sequenom, Stephanie Seidman, Heller Ehrman White and McAuliffe, July 8, 2003: US06589485 (92 worldwide citation)

Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and sequences in the molecules are provided. Arrays of oligonucleotides for performing mass spectrometric analyses are provided. In one aspect, a solid support is provided that includes a plura ...


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Joseph A Monforte, Thomas A Shaler, Yuping Tan, Christopher H Becker: Methods of screening nucleic acids using volatile salts in mass spectrometry. Sequenom, Stephanie Seidman, Heller Ehrman White & McAuliffe, October 22, 2002: US06468748 (92 worldwide citation)

This invention relates to methods for screening nucleic acids for mutations by analyzing nonrandomly fragmented nucleic acids using mass spectrometric techniques and to procedures for improving mass resolution and mass accuracy of these methods of detecting mutations.


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Thomas Becker, Hubert Köster, Charles Cantor: Systems and methods for performing reactions in an unsealed environment. Sequenom, Stephanie Seidman, Heller Ehrman White & McAuliffe, November 26, 2002: US06485913 (92 worldwide citation)

Open systems for performing submicroliter reactions are provided. The systems can include a support for performing the reaction; a liquid dispensing system for dispensing a submicroliter amount of a liquid to a site on or in the support; a temperature controlling device for regulating the temperatur ...


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James Chen, Brian Wilkerson, Dave Brown, Darrin Huston, Mike McQuade: Patient portable device for photodynamic therapy. Light Science Corporation, Stephanie Seidman, Heller Ehrman White & McAuliffe, September 24, 2002: US06454789 (52 worldwide citation)

A patient portable photodynamic therapy device securable to a patient includes a lightweight rechargeable battery and a cold cathode fluorescent (CCF) tube powered thereby. The CCF tube is coupled in light channeling relation to a proximal portion of a biocompatible optical fiber, which includes a d ...


9
Soumitra Shanker Ghosh, Eoin D Fahy: End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids. Siska Diagnostics, Stephanie Seidman Brown Martin Haller & McClain, September 2, 1997: US05663242 (46 worldwide citation)

Methods for covalent attachment of oligonucleotides to solid supports such that substantially all of the oligonucleotides are attached via their 5'-ends are provided. The solid supports with attached oligonucleotides are produced. Thiol-oligonucleotides are attached to bromoacetyl-derivatized polyac ...


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Jochen Harald Stritzker, Phil Hill, Aladar A Szalay, Yong A Yu: Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders. Genelux Corporation, K & L Gates, Stephanie Seidman, July 27, 2010: US07763420 (42 worldwide citation)

Described herein are methods for detecting a microorganism or cell in a subject and methods for detecting, imaging or diagnosing a site, disease, disorder or condition in a subject using microorganisms or cells. Also described are methods which use microorganisms or cells for treating a disease, dis ...