1
Hubert Koster, David M Lough: Beads bound to a solid support and to nucleic acids. Sequenom, Stephanie L Heller Ehrman White & McAuliffe Seidman, October 17, 2000: US06133436 (267 worldwide citation)

Novel compositions comprised of at least one bead conjugated to a solid support and further conjugated to at least one nucleic acid and preferred methods for making the novel compositions are described. As compared to "flat" surfaces, beads linked to a solid support provide an increased surface area ...


2
Daniel P Little, Hubert Koster: Systems and methods for preparing low volume analyte array elements. Sequenom, Stephanie L Heller Ehrman White & McAuliffe Seidman, February 15, 2000: US06024925 (219 worldwide citation)

The invention provides, in one aspect, serial and parallel dispensing tools that can deliver defined and controlled volumes of fluid to generate multi-element arrays of sample material on a substrate surface. The substrates surfaces can be flat or geometrically altered to include wells of receiving ...


3
Hubert Koster, G Scott Higgens, Daniel P Little: DNA diagnostics based on mass spectrometry. Sequenom, Stephanie L Heller Ehrman White & McAuliffe Seidman, March 28, 2000: US06043031 (193 worldwide citation)

The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a pre ...


4
Hubert Koster: DNA sequencing by mass spectrometry via exonuclease degradation. Sequenom, Stephanie L Heller Ehrman White & McAuliffe Seidman, October 31, 2000: US06140053 (186 worldwide citation)

The invention provides fast and highly accurate mass spectrometer based processes for directly sequencing a target nucleic acid (or fragments generated from the target nucleic acid), which by means of protection, specificity of enzymatic activity, or immobilization, are unilaterally degraded in a st ...


5
Hubert Koster: DNA sequencing by mass spectrometry via exonuclease degradation. Sequenom, Stephanie L Heller Ehrman White & McAuliffe Seidman, June 13, 2000: US06074823 (168 worldwide citation)

The invention provides fast and highly accurate mass spectrometer based processes for directly sequencing a target nucleic acid (or fragments generated from the target nucleic acid), which by means of protection, specificity of enzymatic activity, or immobilization, are unilaterally degraded in a st ...


6
Franz Hillenkamp: Method and apparatus for MALDI analysis. Sequenom, Stephanie L Heller Ehrman White & McAuliffe Seidman, August 29, 2000: US06111251 (139 worldwide citation)

Matrix assisted laser desorption/ionization is performed in a manner to thermalize large analyte ions in a plume of desorbed material for spectroscopic analysis. The thermalized ions have a low or zero mean velocity and are presented at a well-defined instant in time, reducing artifacts and sharpeni ...


7
Gyula Hadlaczky, Aladar A Szalay: Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes. Chromos Molecular Systems, The Biological Research Center of the Hungarian Academy of Sciences, Stephanie L Heller Ehrman White & McAuliffe Seidman, February 15, 2000: US06025155 (120 worldwide citation)

Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to ...


8
Hubert Koster, Andreas Ruppert: Filtration processes, kits and devices for isolating plasmids. Sequenom, Stephanie L Heller Ehrman White & McAuliffe Seidman, November 14, 2000: US06146854 (106 worldwide citation)

Processes, kits and preferred devices for rapidly isolating large numbers of plasmid DNAs from plasmid containing cells and for performing high throughput DNA sequencing are described.


9
Bruce Bryan: Bioluminescent novelty items. Stephanie L Heller Ehrman White & McAuliffe Seidman, March 2, 1999: US05876995 (95 worldwide citation)

Systems and apparatus for generating bioluminescence, and combinations of these systems and apparatus with inanimate articles of manufacture to produce novelty items are provided. These novelty items, which are articles of manufacture, are designed for entertainment, recreation and amusement, and in ...


10
Michael Anthony Akong, Michael Miller Harpold, Gonul Velicelebi, Paul Brust: Automated assays and methods for detecting and modulating cell surface protein function. Sibia Neurosciences, Stephanie L Heller Ehrman White & McAuliffe Seidman, May 2, 2000: US06057114 (81 worldwide citation)

Automated assays for detecting and measuring ion channel and cell surface receptor activity and for identifying compounds that modulate or potentiate such activity are provided. Among the assays are fluorescent indicator-based assays that use cells containing effective levels of a fluorescent indica ...