1
Magnani John L: Oligosaccharides and conjugates thereof for the treatement of pseudomonas bacteria infection. Glycomimetics, Magnani John L, sSHARKEY Richard G, July 15, 2004: WO/2004/058304 (17 worldwide citation)

Compositions and methods are provided related to Pseudomonas bacteria. The compositions and methods may be used for diagnosis and therapy of medical conditions involving infection with Pseudomonas bacteria. Such infections include Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis. ...


2
Magnani John L, Patton John T Jr, Sarkar Arun K: Glycomimetic antagonists for both e- and p-selectins. Glycomimetics, Magnani John L, Patton John T Jr, Sarkar Arun K, sSHARKEY Richard G, June 16, 2005: WO/2005/054264 (13 worldwide citation)

Compounds and methods are provided for modulating in vivo and in vivo processes mediated by selectin biniding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g. inhibit or enhance) a selectin-mediated function comprise particular ...


3
Magnani John L: Pan-selectin inhibitor with enhanced pharmacokinetic activity. Glycomimetics, Magnani John L, sSHARKEY Richard G, October 15, 2009: WO/2009/126556 (4 worldwide citation)

Compounds, compositions and methods are provided for treatment of diseases or complications associated therewith, in which a selectin plays a role. More specifically, particular glycomimetics and uses thereof are described. For example, use of particular glycomimetics for treating sickle cell diseas ...


4
Cheever Martin A, Disis Mary L: Intracellular domain of the her-2/neu protein for prevention or treatment of malignancies. University Of Washington, Cheever Martin A, Disis Mary L, sSHARKEY Richard G, October 3, 1996: WO/1996/030514 (3 worldwide citation)

Compounds and compositions for eliciting or enhancing immune reactivity to HER-2/$i(neu) protein are disclosed. The compounds include polypeptides and nucleic acid molecules encoding such peptides. The compounds may be used for the prevention or treatment of malignancies in which the HER-2/$i(neu) o ...


5
Loeb Lawrence A, Kim Baek: Methods and compositions for screening for anti-aids drugs. University Of Washington, sSHARKEY Richard G, August 24, 1995: WO/1995/022622

Methods and compositions related to AIDS are disclosed. Using the methods of the present invention, candidate compounds may be screened for the ability to inhibit reverse transcriptase of human immunodeficiency virus ('HIV RT'). Active HIV RT mutants may be detected by the disclosed methods. The pre ...


6
Houghton Raymond L, Van, Aken Morgan, Jones Tobin K: Methods for determining the invasiveness of a bladder tumor. Bard Diagnostic Sciences, sSHARKEY Richard G, February 2, 1995: WO/1995/003547

Complexes (which include basement membrane components) and their polypeptide components are found to be related to the invasiveness of a bladder tumor. Detection of such complexes or constituents in a urine sample by immunological or non-immunological methods permits determining the invasiveness of ...


7
Malins Donald C: Methods of screening for a tumor or tumor progression to the metastatic state. Pacific Northwest Research Foundation, Malins Donald C, sSHARKEY Richard G, September 25, 1997: WO/1997/035036

Methods of screening for a tumor or tumor progression to the metastatic state are disclosed. The screening methods are based on the characterization of DNA by principal components analysis (PCA) of spectral data yielded by Fourier transform-infrared (FT-IR) spectroscopy of DNA samples. The methods a ...


8
Graves Scott S, Reno John M, Mallet Robert W, Hylarides Mark D, Searle Stephen M J, Henry Andrew H, Pedersen Jan T, Rees Anthony R: Humanized antibodies that bind to the same antigen as bound by antibody nr-lu-13, and their use in pretargeting methods. Neorx Corporation, sSHARKEY Richard G, December 11, 1997: WO/1997/046589

Humanized antibodies which bind the NR-LU-13 antigen, conjugates containing such antibodies, and their use in pretargeting methods and conventional antibody therapy and immunodiagnosis are provided.


9
Kasina Sudhakar: Tetraaza- or n2s2- complexants, and their use in radiodiagnostics or radiotherapy. Neorx Corporation, sSHARKEY Richard G, October 8, 1998: WO/1998/043678

The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent other than hydrogen, and methods for making and ...


10
Loeb Lawrence A, Essigmann John M: Methods of screening for nucleoside analogs that are incorporated by hiv reverse transcriptase and cause incorrect base pairing. Loeb Lawrence A, sSHARKEY Richard G, January 11, 1996: WO/1996/000797

Methods and compositions related to HIV are disclosed. Using the methods of the present invention, nucleoside analogs may be screened for the ability to be incorporated by reverse transcriptase of human immunodeficiency virus ('HIV RT') and cause incorrect base pairing. Progressive mutation of the v ...