1
Gregory P Winter: Recombinant altered antibodies and methods of making altered antibodies. Medical Research Council, Spencer Frank & Schneider, July 6, 1993: US05225539 (1046 worldwide citation)

An altered antibody is produced by replacing the complementarity determining regions (CDRs) of a variable region of an immunoglobulin (Ig) with the CDRs from an Ig of different specificity, using recombinant DNA techniques. The gene coding sequences for producing the altered antibody may be produced ...


2
Jon Manship, Michel Vinneau, David Ross, Nathalie Hache, Charles Maillet: Video gaming machine. SPIELO Manufacturing Incorporated, Spencer Frank & Schneider, February 28, 1995: US05393061 (633 worldwide citation)

A video slot machine includes a display screen on which the wheels of a slot machine are simulated. The display screen is divided into an array of cells with each cell displaying an individual game element selected randomly from a group of available game elements during a game play. Pay-out lines ar ...


3
Gregory P Winter, Alexander R Duncan, Dennis R Burton: Antibodies with altered effector functions. Scotgen Biopharmaceuticals Incorporated, Spencer & Frank, April 29, 1997: US05624821 (538 worldwide citation)

An antibody with an altered function, e.g. altered affinity for an effector ligand such as Fc receptor (FcR) on a cell or the C1 component of complement is produced by replacing at least one amino acid residue in the constant portion of the antibody with a different residue.


4
Franz Laermer, Andrea Schilp: Method of anisotropically etching silicon. Robert Bosch, Spencer & Frank, March 26, 1996: US05501893 (466 worldwide citation)

A method of anisotropic plasma etching of silicon to provide laterally defined recess structures therein through an etching mask employing a plasma, the method including anisotropic plasma etching in an etching step a surface of the silicon by contact with a reactive etching gas to removed material ...


5
Gregory Paul Winter, Alexander Robert Duncan, Dennis Raymond Burton: DNA encoding antibodies with altered effector functions. Scotgen Biopharmaceuticals Incorporated, Spencer & Frank, July 15, 1997: US05648260 (463 worldwide citation)

The DNA encoding an antibody with an altered function, e.g. altered affinity for an effector ligand such as Fc receptor (FcR) on a cell or the Cl component of complement is produced by replacing the nucleic acid encoding at least one amino acid residue in the constant portion of the antibody with nu ...


6
Gerhard Fuhrmann, Ulrich Gross, Bertram Kaden, Herman Josef Schmitz, Thomas Fritz, Curt Kranz: Intervertebral disk endoprosthesis. Mecron Medizinische Produkte, Spencer & Frank, March 26, 1991: US05002576 (459 worldwide citation)

An intervertebral disk endoprosthesis is filled with an elastic material and provided with cover plates at its end faces, and has a circular or elliptical corrugated tube surrounding the viscoelastic material, the tube being terminated by cover plates.


7
Ulrich Gross, Herman Josef Schmitz, Bertram Kaden, Gerhard Fuhrmann: Intervertebral implant. Spencer Frank & Schneider, April 26, 1994: US05306308 (447 worldwide citation)

An intervertebral implant consisting of a disc-shaped spacer made of rigid material and insertable between opposed and adjacent vertebrae in which the opposing sides (1, 2) of the implant bordering the vertebrae are circular discs and have a central raised dome (3 or 4) and roof-shaped projections t ...


8
Ron S Dembo: Scenario optimization. Spencer Frank & Schneider, September 15, 1992: US05148365 (318 worldwide citation)

A method and apparatus are provided for optimally allocating available resources in a physical system defined by a mathematical model having parameters of uncertain values. The method comprises the steps of firstly assigning a value to each of the uncertain parameters in the mathematical model based ...


9
Armin Frank, Horst Niederlein: Coin operated jukebox device using data communication network. NSM Aktiengesellschaft, Spencer Frank & Schneider, August 23, 1994: US05341350 (314 worldwide citation)

A coin-operated music playing machine or jukebox includes a coin unit, a viewing screen, an input keyboard, and at least one loudspeaker. The jukebox is connected to a central music store via a remote data transmission line, preferably an ISDN line. The jukebox has digital/analog converters and ampl ...


10
Jean Francois Jeanson, Marc Ameil, Herve Dinville, Jean Huppert, Thierry Marnay, Michel Gau: Spacer implant for substituting missing vertebrae. JBS, Spencer & Frank, March 3, 1998: US05723013 (264 worldwide citation)

An implant for replacing a removed vertebra includes an outer sleeve having a longitudinal axis and a peripheral inner surface. The inner surface has a series of axially adjoining, peripheral grooves lending the inner surface a sawtooth-shaped configuration when viewing the inner sleeve in axial sec ...