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Anderson Kenneth C, Hideshima Teru, Mitsiades Constantine S, Mitsiades Nicholas: Methods and compositions for treating cancer using proteasome inhibitors. Dana Farber Cancer Institute, Anderson Kenneth C, Hideshima Teru, Mitsiades Constantine S, Mitsiades Nicholas, SMITH DeAnn F, May 27, 2004: WO/2004/043374 (22 worldwide citation)

The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatme ...


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Cunningham Phillip R: Methods and compositions for the identification of antibiotics that are not susceptible to antibiotic resistance. Wayne State University, Cunningham Phillip R, SMITH DeAnn F, January 8, 2004: WO/2004/003511 (19 worldwide citation)

Compositions and methods are provided to identify functional mutant ribosomes that may be used as drug targets. The compositions and methods allow isolation and analysis of mutations that would normally be lethal and allow direct selection of rRNA mutants with predetermined levels of ribosome functi ...


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Monahan John E, Zhao Xumei, Chen Yan, Glatt Karen, Kamatkar Shubhangi: Compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer. Millenium Pharmaceuticals, Monahan John E, Zhao Xumei, Chen Yan, Glatt Karen, Kamatkar Shubhangi, SMITH DeAnn F, March 4, 2004: WO/2004/018999 (18 worldwide citation)

The invention relates to nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are also provided.


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Schlegel Robert, Endege Wilson O, Monahan John E: Genes differentially expressed in human prostate cancer and their use. Millennium Predictive Medicine, SMITH DeAnn F, August 23, 2001: WO/2001/060860 (13 worldwide citation)

The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human prostate cancers. A variety of novel markers are provided, wherein changes in the levels of expression of one or more of the markers is correlated with the presence of prostate canc ...


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Kaufman Randal J, Zhang Kezhong: Compositions and methods for modulating the acute phase response. The Regents Of The University Of Michigan, Kaufman Randal J, Zhang Kezhong, SMITH Deann F, January 4, 2007: WO/2007/002493 (11 worldwide citation)

Methods and compositions are provided for modulating the acute phase response. In particular, methods and compositions are provided that inhibit the acute phase response, including expression or production of C-reactive protein (CRP). The invention accordingly has applicability to the modulation of ...


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SHARPE ARLENE H: Modulators of immunoinhibitory receptor pd-1, and methods of use thereof. PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Smith Deann F, July 7, 2011: WO/2011/082400 (7 worldwide citation)

Disclosed are an assay to identify modulators of the PD-1 :PD-L pathway and PD-1 :PD-L pathway modulators, e.g., compounds and pharmaceutical compositions thereof. Methods for treating diseases influenced by modulation of the PD-1 :PD-L pathway such as, for example, autoimmune diseases, inflammatory ...


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Chin Lynda, Depinho Ronald A, Brennan Cameron, Aguirre Andrew J: Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer. Dana Farber Cancer Institute, Chin Lynda, Depinho Ronald A, Brennan Cameron, Aguirre Andrew J, SMITH DeAnn F, December 15, 2005: WO/2005/118869 (6 worldwide citation)

The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations ...


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FINLEY DANIEL: Compositions and methods for enhancing proteasome activity. PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Smith Deann F, August 4, 2011: WO/2011/094545 (6 worldwide citation)

Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp 14 results in increased proteasome efficiency. The present invent ...


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Vasquez Maximiliano, Feldhaus Michael, Gerngross Tillman U, Wittrup K Dane: Rationally designed, synthetic antibody libraries and uses therefor. Adimab, Vasquez Maximiliano, Feldhaus Michael, Gerngross Tillman U, Wittrup K Dane, SMITH DeAnn F, March 19, 2009: WO/2009/036379 (6 worldwide citation)

The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally c ...