1
Oyhenart Jorge, Gallet Xavier, Borrelly Gilles, Guyon Thierry, Vega Manuel, Drittanti Lila: Modified coagulation factor ix polypeptides and use thereof for treatment. Nautilus Technology, Oyhenart Jorge, Gallet Xavier, Borrelly Gilles, Guyon Thierry, Vega Manuel, Drittanti Lila, SEIDMAN Stephanie L, December 27, 2007: WO/2007/149406 (35 worldwide citation)

Provided are modified factor IX (FIX) polypeptides and methods of generating modified FIX polypeptides. Also provided are pharmaceutical compositions, including compositions formulation for oral administration, that contain the modified FIX polypeptides, and methods of treatment using modified FIX p ...


2
Zhi Lin, Higuchi Robert I, Kallel E Adam, Van, Oeveren Cornelis Arjan, Chen Jyun Hung, Ruppar Daniel A, Pedram Bijan, Lau Thomas Lot Stevens, Miller Todd: Androgen receptor modulator compounds and methods. Ligand Pharmaceuticals Incorporated, Zhi Lin, Higuchi Robert I, Kallel E Adam, Van, Oeveren Cornelis Arjan, Chen Jyun Hung, Ruppar Daniel A, Pedram Bijan, Lau Thomas Lot Stevens, Miller Todd, SEIDMAN Stephanie L, September 29, 2005: WO/2005/090282 (34 worldwide citation)

Provided herein are compounds having a structure selected from among Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V) and Formula (VI) that are androgen receptor modulators and/or androgen receptor binding agents. Also disclosed are methods of making and using such compounds, incl ...


3
Zhi Lin, Kallel E Adam, Nguyen Bao Ngoc, Adams Mark E, Shen Yixing, Lau Thomas Lot Stevens, Chen Jyun Hung, Tyhonas John S, Ardecky Robert J, Miller Todd A, Loren Jon C: Thiazole derivatives as androgen receptor modulator compounds. Ligand Pharmaceuticals Incorporated, Zhi Lin, Kallel E Adam, Nguyen Bao Ngoc, Adams Mark E, Shen Yixing, Lau Thomas Lot Stevens, Chen Jyun Hung, Tyhonas John S, Ardecky Robert J, Miller Todd A, Loren Jon C, SEIDMAN Stephanie L, October 16, 2008: WO/2008/124000 (25 worldwide citation)

Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors and/or modulate the amount of androgen receptors and/or reduce the number of androgen receptors in a cell and/or degrade androgen receptors in a cell; and to methods for making and using such ...


4
Jin Pei, Shepard Michael H: Cell surface receptor isoforms and methods of identifying and using the same. Receptor Biologix, Jin Pei, Shepard Michael H, SEIDMAN Stephanie L, December 1, 2005: WO/2005/113596 (24 worldwide citation)

Isoforms of cell surface receptors, including isoforms of receptor tyrosine kinases and pharmaceutical compositions containing receptor tyrosine kinase isoforms are provided. Chimeras of and conjugates containing the cell surface receptors that contain a portion, such as or a part thereof of an extr ...


5
Hussa Robert, Fischer Colbrie Mark, Lapointe Jerome, Hickok Durlin, Shorter Simon Charles, Senyei Andrew: Oncofetal fibronectin as a marker for disease and other conditions and methods for detection of oncofetal fibronectin. Adeza Biomedical Corporation, Hussa Robert, Fischer Colbrie Mark, Lapointe Jerome, Hickok Durlin, Shorter Simon Charles, Senyei Andrew, SEIDMAN Stephanie L, March 9, 2006: WO/2006/026020 (24 worldwide citation)

Methods and products for the detection of oncofetal fibronectin indicating molecules in samples are provided. Methods for imaging of oncofetal fibronectin are provided. In some methods provided herein, the sample is treated with a reagent and/or contacted with anon-specific binder. Provided are meth ...


6
Frost Gregory I, Jiang Ping, Thompson Curtis B: Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions. Halozyme, Frost Gregory I, Jiang Ping, Thompson Curtis B, SEIDMAN Stephanie L, October 22, 2009: WO/2009/128917 (22 worldwide citation)

Provided are combinations, compositions and kits containing a hyaluronan degrading enzyme, such as a soluble hyaluronidase, for treatment of hyaluronan- associated conditions, diseases and disorders. In one example, the products include an additional agent or treatment. Such products can be used in ...


7
SMIDER VAUGHN: Combinatorial antibody libraries and uses thereof. FABRUS, Seidman Stephanie L, May 14, 2010: WO/2010/054007 (21 worldwide citation)

Methods for making a combinatorial antibody library from human germline segments are provided. Also provided are libraries of nucleic acid molecules compiled from germline segments encoding VL chains and libraries of nucleic acid molecules encoding VH chains, and resulting antibody libraries. The li ...


8
Zhi Lin: (sarms) And uses thereof. Ligand Pharmaceuticals Incorporated, Zhi Lin, SEIDMAN Stephanie L, July 2, 2009: WO/2009/082437 (19 worldwide citation)

Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors; and to methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.


9
Kounnas Maria, Patrick Aaron, Velicelebi Gonul, Wagner Steven: Methods and compositions for modulating amyloid beta. Neurogenetics, Kounnas Maria, Patrick Aaron, Velicelebi Gonul, Wagner Steven, SEIDMAN Stephanie L, March 4, 2004: WO/2004/018997 (18 worldwide citation)

Provided herein are methods and compositions for detecting, assessing and modulating &bgr;-amyloid peptide (A&bgr;) levels and/or processing of amyloid precursor protein. Methods for screening and/or identifying agents that modulate processing of APP or the levels of &bgr;-amyloid peptides, and meth ...


10
Notz Wolfgang Reinhard Ludwig, Scott Robert William, Zhao Lishan, Tao Junhua: Transaminase-based processes for preparation of pregabalin. Bioverdant, Notz Wolfgang Reinhard Ludwig, Scott Robert William, Zhao Lishan, Tao Junhua, SEIDMAN Stephanie L, October 23, 2008: WO/2008/127646 (17 worldwide citation)

Provided herein are compounds and processes to prepare intermediates and precursors of pregabalin and related compositions, and processes for the preparation of pregabalin.