1
Robert A Clarke, Robin G Pauley, Ronald S Hill, James H Brauker, Shmuel Sternberg, Daniel R Boggs: Closed porous chambers for implanting tissue in a host. Baxter International, Paul C Flattery, Sarah E Bates, Daniel D Ryan, September 6, 1994: US05344454 (456 worldwide citation)

Improved Implant assemblies and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish an improved chamber for holding the implanted cells. The chambers include first and second wall elements and an intermediate sealing ...


2
James H Brauker, Ronald S Hill, Laura A Martinson, Daniel R Boggs, Robert C Johnson: Tissue inplant systems and methods for sustaining viable high cell densities within a host. Baxter International, Sarah E Bates, Daniel D Ryan, Paul C Flattery, May 24, 1994: US05314471 (387 worldwide citation)

Implant assemblies and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish a boundary between the host and the implanted cells. The boundary has a pore size, an ultimate strength, and a metabolic transit value that a ...


3
Eddie K M Chan, Robin G Pauley, James H Brauker, Lecon Woo: Laminated barriers for tissue implants. Baxter International, Paul C Flattery, Sarah E Bates, Daniel D Ryan, September 26, 1995: US05453278 (236 worldwide citation)

Improved Implant assemblies and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish an improved boundary between the host and the implanted cells. The boundary structure is laminated, combining elements having differ ...


4
Timothy N Estep: Purified hemoglobin solutions and method for making same. Baxter International, Paul C Flattery, Marjorie D Hunter, Sarah E Bates, May 16, 1989: US04831012 (45 worldwide citation)

Hemoglobin solutions are purified by heating in the presence of a reducing agent or other deoxygenating conditions such that nonhemoglobin proteins are selectively precipitated and/or virus is inactivated while minimizing hemoglobin loss. For example the hemoglobin is heated in the form of deoxyhemo ...


5
Timothy N Estep: Purified hemoglobin solutions and method for making same. Baxter International, Paul C Flattery, Susan Bennett Fentress, Sarah E Bates, August 29, 1989: US04861867 (44 worldwide citation)

Hemoglobin solutions are purified by heating in the presence of a reducing agent or other deoxygenating conditions such that nonhemoglobin proteins are selectively precipitated and/or virus is inactivated while minimizing hemoglobin loss.


6
Robert J Przybelski: Administration of low dose hemoglobin to increase perfusion. Baxter International, Kent Barta, Sarah E Bates, Paul C Flattery, August 2, 1994: US05334706 (37 worldwide citation)

This invention provides a method to therapeutically increase perfusion in a mammal comprising administering stroma-free hemoglobin at a dose ranging from the least amount effective to increase perfusion, up to a dose of about 2500 mg per kilogram of body weight.


7
Richard L Kandler, John C Spicuzza: Stable hemoglobin based composition and method to store same. Baxter International, Kent Barta, Sarah E Bates, Paul C Flattery, October 4, 1994: US05352773 (26 worldwide citation)

The present invention relates to a stable hemoglobin based composition having sufficiently low levels of methemoglobin to effectively function as an oxygen carrying solution upon administration to a patient made by the process comprising: a) adding an oxygenated or deoxygenated form of said blood su ...


8
Timothy N Estep: Purified virus-free hemoglobin solutions and method for making same. Baxter International, Sarah E Bates, January 25, 1994: US05281579 (21 worldwide citation)

An aqueous solution of cross-linked hemoglobin free of active virus and having a P50 under physiologic conditions of at least 26 mm. Hg. are disclosed.


9
Robert J Przybelski: Administration of low dose hemoglobin to increase perfusion. Baxter International, Paul C Flattery, Sarah E Bates, April 23, 1996: US05510464 (20 worldwide citation)

This invention provides a method to therapeutically increase perfusion in a mammal comprising administering stroma-free hemoglobin at a dose ranging from the least amount effective to increase perfusion, up to a dose of about 2500 mg per kilogram of body weight.


10
Ton T Hai, Deanna J Nelson, Ana Srnak: Process for the production of crosslinked hemoglobin in the presence of sodium tripolyphosphate. Baxter International, Paul C Flattery, Sarah E Bates, July 7, 1992: US05128452 (19 worldwide citation)

A process for the production of crosslinked hemoglobin comprises crosslinking hemoglobin in the presence of sodium tripolyphosphate.