1
Heini Ernst, Albert Guenin: Automatic regulation of respirators. Hoffmann La Roche, Samuel L Welt, George M Gould, Mark L Hopkins, June 8, 1976: US03961627 (170 worldwide citation)

Regulation of the flow and pressure of the respiration gas in a respirator coupled to a patient is disclosed in regard to a respirator arrangement having a flow and pressure measuring device arranged proximate the patient connection for determining the flow and pressure of the respiration gas and co ...


2
John E Hearst, Henry Rapoport, Stephen Isaacs, Che Kun J Shen: Psoralens. Hoffmann La Roche, Samuel L Welt, George M Gould, November 7, 1978: US04124598 (90 worldwide citation)

New psoralen compounds have been synthesized. The compounds all include the addition of substituent groups at the 4' position on the basic trioxsalen structure. Specifically, the compounds have the structure: ##STR1## wherein X may be any desired substituent such as halogenated alkyls, alcohols, eth ...


3
Heini Ernst, Albert Guenin: Respirator. Hoffmann La Roche, Samuel L Welt, Bernard S Leon, Mark L Hopkins, August 3, 1976: US03972327 (83 worldwide citation)

A respirator used to replace or assist the respiratory function and automatically regulate the respiration gas flow and pressure during the inspiration phase and expiration phase comprising means for measuring the flow and pressure of respiration gas and providing electrical output signals, valve me ...


4
Philippe Racine, Jean Claude Higelin, Roland Engelhardt, Wolfgang Mindt: Apparatus for measuring substrate concentrations. Hoffmann La Roche, Samuel L Welt, George M Gould, January 25, 1977: US04005002 (57 worldwide citation)

The concentration of substrates of enzyme reactions is measured by determining the current produced at a platinum or gold electrode by oxidizing an acceptor utilizing a measuring device comprising a measuring cell, an enzyme electrode in contact with the fluid sample and containing a platinum or gol ...


5
William Charles Grimmell, Gilbert Carl Kaetzel, John Milton Moran, George Michael Zanko: Apparatus for color recognition and defect detection of objects such as capsules. Hoffmann La Roche, Samuel L Welt, George M Gould, Mark L Hopkins, April 4, 1978: US04082188 (56 worldwide citation)

Method and apparatus for high-speed automatic inspection and processing of large numbers of solid discrete particular objects such as multicolored capsule dose forms in regard to color and/or defect detection, in which virtually all unacceptable material is isolated and an accurate running and total ...


6
Thomas William Antoshkiw, Marco Alfred Cannalonga, Arnold Koff: Water dispersible carotenoid preparations and processes thereof. Hoffmann La Roche, Samuel L Welt, Bernard S Leon, William M Farley, December 21, 1976: US03998753 (54 worldwide citation)

This invention relates to water dispersible carotenoid compositions in liquid or powder form which are suitable for use in the preparation of colored optically clear, stable, aqueous compositions and which can be incorporated into, e.g., pharmaceutical or cosmetic preparations or animal feedstuff an ...


7
Allan L Goldstein, Teresa L K Low, Chun Yen Lai, Su Sun Wang: Thymosin alpha 1. Board of Regents of the University of Texas, Hoffmann La Roche, Samuel L Welt, Jon S Saxe, George M Gould, March 14, 1978: US04079127 (53 worldwide citation)

The amino acid sequence of a biologically active polypeptide hormone isolated from calf thymus termed thymosin .alpha..sub.1 has been determined. Thymosin .alpha..sub.1 is a heat stable acidic molecule composed of 28 amino acid residues. This peptide is one of several present in thymosin fraction 5 ...


8
Thomas B Harsch: Surface alignment method for liquid crystal cells and production of polarizers therefor. Hoffmann La Roche, Samuel L Welt, Bernard S Leon, Mark L Hopkins, March 2, 1976: US03941901 (50 worldwide citation)

Method for producing homogeneous surface alignment of liquid crystal materials by applying to the surfaces of transparent plates bounding a liquid crystal film a polymer which is subjected to a shear thinning technique to cause elongation and alignment of long chain polymers. In certain embodiments ...


9
Hochberg Howard Martin, King Eugene: "Pacemaker" monitoring technique and system. Hoffman La Roche, Samuel L Welt et al, January 1, 1974: US3782367 (48 worldwide citation)

A monitoring system operates to indicate the effectiveness of cardiac pacer operation in a cardiac pacer carrying patient. A predetermined time interval from the onset of a pacer spike defines minimum and maximum specific times as criteria for establishing digital techniques to ascertain a capture e ...


10
Richard William Avenia, James Gordon Christenson, Benjamin Pecherer: Immunoassay for pharmacologically active phenethylamines. Hoffmann La Roche, Samuel L Welt, George M Gould, August 9, 1977: US04041076 (48 worldwide citation)

New hapten compositions useful in preparing antigens which may be employed in eliciting antibodies useful in an improved radioimmunoassay for pharmacologically active phenethylamines are disclosed. Particular phenethylamins which are preferably detected by the present radioimmunoassay include the ca ...