Stuart Edwards, John Gaiser, David Utley, Scott West, Jay Chin: Expandable electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions. Curon Medical, Ryan Kromholz & Manion SC, July 10, 2001: US06258087 (465 worldwide citation)

Expandable assemblies for treating a tissue region at or near a sphincter comprises a support basket formed from an array of spines. A mechanism flexes the spines to expand and collapse the basket. Electrodes carried by the spines for advancement in a path to penetrate the tissue region upon expansi ...

Mark A Reiley, Arie Scholten, Karen D Talmadge, Robert M Scribner: Systems and methods for treating fractured or diseased bone using expandable bodies. Kyphon, Ryan Kromholz & Manion SC, May 31, 2005: US06899719 (188 worldwide citation)

Systems and methods treat fractured or diseased bone by deploying more than a single therapeutic tool into the bone. In one arrangement, the systems and methods deploy an expandable body in association with a bone cement nozzle into the bone, such that both occupy the bone interior at the same time. ...

Stuart D Edwards, John Gaiser, David S Utley, Scott West, Jay Qin: Assemblies to visualize and treat sphincters and adjoining tissue regions. Curon Medical, Ryan Kromholz & Manion SC, July 23, 2002: US06423058 (171 worldwide citation)

Assemblies for treating a tissue region at or near a sphincter have a support structure with a distal end and an electrode carried by the support structure for contact with the tissue region. A lumen in the support structure accommodates passage of a body through the support structure and beyond the ...

John Gaiser, David Utley: Systems and methods for treating tissue in the crura. Curon Medical, Ryan Kromholz & Manion SC, April 15, 2003: US06547776 (153 worldwide citation)

Tissue in the crura is treated by advancing a tissue penetrating element from a catheter tube through a wall of the esophagus. The tissue penetrating element is operated to affect a tightening of the crura, e.g., to treat hiatal hernia.

Juan C Parodi: Systems and methods for applying a suture within a blood vesel lumen. Aptus Endosystems, Ryan Kromholz & Manion SC, October 5, 2004: US06800081 (113 worldwide citation)

Systems and methods apply a suture within a blood vessel lumen. The systems and methods advance within a blood vessel lumen a catheter tube having a distal region that carries a suture applicator. The systems and methods operate the suture applicator from a location external to the blood vessel lume ...

Daniel John DiLorenzo: Method and apparatus for neuromodulation and physiologic modulation for the treatment of metabolic and neuropsychiatric disease. DiLorenzo Biomedical, Daniel John DiLorenzo, Ryan Kromholz & Manion SC, May 5, 2009: US07529582 (80 worldwide citation)

A method and apparatus for physiological modulation, including neural and gastrointestinal modulation, for the purposes of treating several disorders, including obesity, depression, epilepsy, and diabetes. This includes chronically implanted neural and neuromuscular modulators, used to modulate the ...

Raul Chirife: Cardiac pacemaker upper rate limit control. Ryan Kromholz & Manion SC, September 12, 2000: US06119040 (28 worldwide citation)

Method and apparatus for automatically setting a variable upper rate limit for the pacing pulse signal provided by a rate adaptive implantable pacemaker which relies on a non-physiological sensor to determine the pacing needs of the patient. A physiological parameter of the patient's condition is se ...

Reiley Mark A: Systems and methods for the fixation or fusion of bone at or near a sacroiliac joint. SI BONE, Ryan Kromholz & Manion Sc, June 10, 2010: WO/2010/065015 (16 worldwide citation)

At least one bone fixation device comprising a stem having a maximum outer diameter is inserted into the sacroiliac joint through a minimally invasive incision path sized approximately at or about the maximum outer diameter of the stem in soft tissue, into the iliac bone, across the sacroiliac joint ...

Dennis McDevitt: Expandable polymer dental implant and method of use. Incumed, Ryan Kromholz & Manion SC, March 8, 2005: US06863530 (12 worldwide citation)

Systems and methods for a dental implant system suitable for an endosteal implant into a jawbone are provided. The systems and methods make use of an expandable polymer sheath insertable into a jawbone, an implant insertable into the sheath and causing expansion of the sheath upon insertion, and an ...

Robert S Reinbold, Richard E Willits, Kim M DeSmidt: Calcium enriched natural cheese. Sargento Foods, Ryan Kromholz & Manion SC, December 28, 1999: US06007852 (12 worldwide citation)

A natural cheese having at least 210 milligrams of calcium per 28 grams of said natural cheese. The calcium enriched natural cheese comprising: a calcium material suspended in a natural cheese by dispersing the calcium material generally throughout a cheese milk and processing the cheese milk into a ...