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Arjan G J Tibbe, Leon W M M Terstappen: Method and apparatus for imaging target components in a biological sample using permanent magnets. Veridex, Ruby T Hope, February 7, 2012: US08110101 (15 worldwide citation)

A system for enumeration of cells in fluids by image cytometry is described for assessment of target populations such as leukocyte subsets in different bodily fluids or bacterial contamination in environmental samples, food products and bodily fluids. Briefly, all cells in a biological sample are fl ...


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Galla Chandra Rao, Christopher Larson, Madeline Repollet, Herman Rutner, Leon W M M Terstappen, Shawn Mark O Hara, Steven Gross: Analysis of circulating tumor cells, fragments, and debris. Veridex, Ruby T Hope, December 11, 2012: US08329422 (14 worldwide citation)

The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CELLSPOTTERĀ® fluorescent microscopy imaging system. Analyzing damaged cells has shown ...


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Frank A W Coumans, Jan Greve, Frank P Modica, Leon W M M Terstappen, Arjan G J Tibbe, John A Verrant: Methods and algorithms for cell enumeration in a low-cost cytometer. Veridex, Ruby T Hope, May 29, 2012: US08189899 (3 worldwide citation)

The enumeration of cells in fluids by flow cytometry is widely used across many disciplines such as assessment of leukocyte subsets in different bodily fluids or of bacterial contamination in environmental samples, food products and bodily fluids. For many applications the cost, size and complexity ...


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Arun B Kulkarni, Gregory R Skover: Stable complexes of crosslinked polyvinylpyrrolidone and iodine and method of making the same. Lawrence D Schuler, Ruby T Hope, February 15, 2000: US06025446 (2 worldwide citation)

A wound treatment material which absorbs wound fluid without overdrying the wound, provides physical cushioning for the wound, and releases an antimicrobial agent (iodine) in a controlled manner to kill harmful micro-organisms without irritating the wound area or adversely affecting would healing. T ...


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Linda Jolliffe, William Murray, Virginia Pulito, Allen Reitz, Xiaobing Li, Linda Mulcahy, Cynthia Maryanoff, Frank Villani: Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia. Ortho McNeil Pharmaceutical, Ruby T Hope, John Wallen III, June 6, 2000: US06071915 (1 worldwide citation)

This invention relates to a series of arylsubstituted piperazines, of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the .alpha.-1a adrenergic receptor, a receptor which has bee ...


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Gee Hong Kuo, William V Murray, Catherine P Prouty: Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia. Ortho McNeil Pharmaceutical, Ruby T Hope, May 16, 2000: US06063785

This invention relates to a series of heterocyclic substituted piperazines of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the (.alpha.-1.sub.a adrenergic receptor, a receptor ...