1
Johnson Alan T, Kaneko Satoru, Mohan Raju, Oda Kozo, Schweiger Edwin J: Isoquinolinone derivatives and their use as therapeutic agents. X Ceptor Therapeutics, Sankyo Company, Johnson Alan T, Kaneko Satoru, Mohan Raju, Oda Kozo, Schweiger Edwin J, ROTH Carol J, July 15, 2004: WO/2004/058717 (47 worldwide citation)

This invention is directed to isoquinolinone derivatives and their use in modulating the activity of orphan nuclear receptors, pharmaceutical compositions containing such derivatives, and methods of using such derivatives in treating disease-states associated with nuclear receptor activity.


2
Kamboj Rajender, Kodumuru Vishnumurthy: Pyridine derivatives for inhibiting human stearoyl-coa-desaturase. Xenon Pharmaceuticals, Kamboj Rajender, Kodumuru Vishnumurthy, Roth Carol J, ROTH Carol J, March 30, 2006: WO/2006/034446 (43 worldwide citation)

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I), where x, y, G, J, K, L, M, W, V, R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined he ...


3
Kamboj Rajender, Zhang Zaihui, Sviridov Serguei, Raina Vandna, Hou Duanjie, Kodumuru Vishnumurthy, Seid, Bagherzadeh Mehran: Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors. Xenon Pharmaceuticals, Kamboj Rajender, Zhang Zaihui, Sviridov Serguei, Raina Vandna, Hou Duanjie, Kodumuru Vishnumurthy, Seid, Bagherzadeh Mehran, Roth Carol J, ROTH Carol J, March 30, 2006: WO/2006/034441 (36 worldwide citation)

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where x, y, J, K, W, V, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmace ...


4
Kamboj Rajender, Zhang Zaihui, Fu Jian Min, Kodumuru Vishnumurthy, Sviridov Serguei, Sadalapure Kashinath, Liu Shifeng, Sun Shaoyi, Hou Duanjie, Chakka Nagasree: Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors. Xenon Pharmaceuticals, Kamboj Rajender, Zhang Zaihui, Fu Jian Min, Kodumuru Vishnumurthy, Sviridov Serguei, Sadalapure Kashinath, Liu Shifeng, Sun Shaoyi, Hou Duanjie, Chakka Nagasree, ROTH Carol J, March 30, 2006: WO/2006/034440 (34 worldwide citation)

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, V R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein ...


5
Chafeev Mikhail, Chowdhury Sultan, Fraser Robert, Fu Jianmin, Hou Duanjie, Kamboj Rajender, Liu Shifeng, Sun Shaoyi, Sun Jianyu, Sviridov Serguei, Bagherzadeh Mehran Seid, Chakka Nagasree, Hsieh Tom, Raina Vandna: Oxindole compounds and their uses as therapeutic agents. Xenon Pharmaceuticals, Chafeev Mikhail, Chowdhury Sultan, Fraser Robert, Fu Jianmin, Hou Duanjie, Kamboj Rajender, Liu Shifeng, Sun Shaoyi, Sun Jianyu, Sviridov Serguei, Bagherzadeh Mehran Seid, Chakka Nagasree, Hsieh Tom, Raina Vandna, ROTH Carol J, October 26, 2006: WO/2006/113864 (32 worldwide citation)

This invention is directed to oxindole compounds that are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of using the compounds are also disclosed.


6
Beatch Gregory N, Choi Lewis Siu Leung, Jung Grace, Liu Yuzhong, Plouvier Bertrand, Wall Richard, Zhu Jeff, Zolotoy Alexander, Barrett Anthony G M, Walker Michael Ja, Yong Sandro L, Sheng Tao: Aminocyclohexyl ether compounds and uses thereof. Cardiome Pharma, Beatch Gregory N, Choi Lewis Siu Leung, Jung Grace, Liu Yuzhong, Plouvier Bertrand, Wall Richard, Zhu Jeff, Zolotoy Alexander, Barrett Anthony G M, Walker Michael Ja, Yong Sandro L, Sheng Tao, ROTH Carol J, November 18, 2004: WO/2004/099137 (31 worldwide citation)

Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.


7
Fu Jianmin, Kodumuru Vishnumurthy, Sviridov Serguei: Fused piperidine derivatives and their uses as therapeutic agents. Xenon Pharmaceuticals, Fu Jianmin, Kodumuru Vishnumurthy, Sviridov Serguei, ROTH Carol J, May 3, 2007: WO/2007/050124 (27 worldwide citation)

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where p, x, K, W, V, R2, R3 and R4 are defined herein. Pharmaceutical compositions comprising the ...


8
Liu Shifeng, Sun Jianyu, Fraser Robert, Fu Jianmin, Kamboj Rajender, Hou Duanjie, Sviridov Serguei: Quinazolinone and fused pyrimidinone compounds and their use in treating sodium channel-mediated diseases or conditions. Xenon Pharmaceuticals, Liu Shifeng, Sun Jianyu, Fraser Robert, Fu Jianmin, Kamboj Rajender, Hou Duanjie, Sviridov Serguei, ROTH Carol J, August 7, 2008: WO/2008/094909 (27 worldwide citation)

This invention is directed to compounds of formula (I): wherein (A), n, R1, R2 and R3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of sodium channel-m ...


9
CHAFEEV MIKHAIL: Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents. XENON PHARMACEUTICALS, Roth Carol J, January 6, 2011: WO/2011/002708 (27 worldwide citation)

This invention is directed to the (S)-enantiomer of the compound of formula (I) or a pharmaceutically acceptable solvate or prodrug thereof. This (S)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated ...


10
Chafeev Mikhail, Chowdhury Sultan, Fraser Robert, Fu Jianmin, Kamboj Rajender, Sviridov Serguei, Bagherzadeh Mehran Seid, Liu Shifeng, Sun Jianyu: Spiroheterocyclic compounds and their uses as therapeutic agents. Xenon Pharmaceuticals, Chafeev Mikhail, Chowdhury Sultan, Fraser Robert, Fu Jianmin, Kamboj Rajender, Sviridov Serguei, Bagherzadeh Mehran Seid, Liu Shifeng, Sun Jianyu, ROTH Carol J, October 19, 2006: WO/2006/110654 (27 worldwide citation)

This invention is directed to spiroheterocyclic compounds of formula (I) : wherein (II) , k, j, p, Q, R1, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, that are use ...