1
John F Gerster: 1H-Imidazo[4,5-c]quinolin-4-amines and antiviral use. Riker Laboratories, Donald M Sell, James A Smith, Robert W Sprague, August 25, 1987: US04689338 (312 worldwide citation)

1H-Imidazo[4,5-c]quinolin-4-amines which are antivirals. Pharmacological methods of using such compounds and pharmaceutical compositions containing such compounds are also described.


2
John F Gerster, Roy T Knafla: Olefinic 1H-imidazo(4,5-c)quinolin-4-amines. Minnesota Mining and Manufacturing Company, Donald M Sell, Walter N Kirn, Robert W Sprague, May 29, 1990: US04929624 (242 worldwide citation)

Novel 1-substituted 1H-imidazo-[4,5-c]quinolin-4-amines are disclosed. These compounds function as antiviral agents, and they are potential synthetic intermediates in the preparation of known antiviral agents and labeled known antiviral agents. This invention also provides intermediates for preparin ...


3
John F Gerster: 1H-imidazo[4,5-c]quinolines and their use as bronchodilating agents. Riker Laboratories, Donald M Sell, James A Smith, Robert W Sprague, October 6, 1987: US04698348 (223 worldwide citation)

1H-imidazo[4,5-c]quinoline which are bronchodilators. Pharmacological methods of using the compounds as bronchodilators, pharmaceutical compositions containing the compounds, and synthetic intermediate for preparing the compounds are also described.


4
Raymond D Skwierczynski, Kenneth R Phares, Richard L Miller, Zheng Jane Li, Michael J Jozwiakowski, Terri F Busch: Formulations and methods for treatment of mucosal associated conditions with an immune response modifier. 3M Innovative Properties Company, MarySusan Howard, Ted K Ringsred, Robert W Sprague, June 12, 2001: US06245776 (207 worldwide citation)

Immune response modifier (IRM) compounds—imidazoquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, 1,2-bridged imidazoquinoline amines, thiazolo- and oxazolo-quinolinamines and pyridinamines, imidazonaphthyridine and tetrahydroimidazonaphthyridine amines—are useful ...


5
Mark A Tomai, David M Hammerbeck, Karl F Swingle: Immune response modifier compounds for treatment of TH2 mediated and related diseases. 3M Innovative Properties Company, Ted K Ringsred, MarySusan Howard, Robert W Sprague, March 21, 2000: US06039969 (200 worldwide citation)

Immune response modifier compounds--imidazoquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, and 1,2-bridged imidazoquinoline amines--are useful for the treatment of TH2 mediated diseases by administering a therapeutically effective amount of such compounds in ord ...


6
Jean Denis Andre, Daniel Lagain: 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines. Riker Laboratories, Donald M Sell, Walter N Kirn, Robert W Sprague, January 29, 1991: US04988815 (175 worldwide citation)

A process for the preparation of 1-substituted, 4-substituted-1H-imidazo[4,5-c]quinolines, intermediates in the preparation of such compounds, and processes for the preparation of such intermediates.


7
Richard L Miller, Mark A Tomai, David I Bernstein, Christopher J Harrison: 1H-imidazo[4,5-C]quinolin-4-amines as vaccine adjuvants. 3M Innovative Properties Company, Ted K Ringsred, MarySusan Howard, Robert W Sprague, July 4, 2000: US06083505 (171 worldwide citation)

An immunogen/vaccine adjuvant composition containing an immunogen in an amount effective to stimulate an immune response and as a vaccine adjuvant a 1H-imidazo[4,5-c]quinolin-4-amine in an amount effective to increase the immune response to the immunogen.


8
Thomas G Hacker, David J Franta: Cassette for tonometric calibration. Minnesota Mining and Manufacturing Company, James D Christoff, Robert W Sprague, Stephen W Bauer, December 7, 1999: US05997818 (169 worldwide citation)

A cassette for tonometric calibration especially useful for systems that measure one or more blood parameters includes a cassette having an elongated fluid chamber. In one embodiment of the invention, the fluid chamber includes an expansion region that reduces the likelihood of bubble coalescence of ...


9
Joseph M D&apos Sa, Jaimeson C Keister: Sonophoresis method and apparatus. 3M Innovative Properties Company, Ted K Ringsred, MarySusan Howard, Robert W Sprague, November 27, 2001: US06322532 (166 worldwide citation)

An ultrasonic transducer that operates in flexure mode provides a highly efficient and compact sonophoresis device. Such a device is particularly useful for efficiently enhancing permeation of a substance through a membrane, such as dermal and mucosal membranes for purposes of transdermal/transmucos ...


10
John F Gerster, Kyle J Lindstrom, Gregory J Marszalek, Bryon A Merrill, John W Mickelson, Michael J Rice: Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof. 3M Innovative Properties Company, MarySusan Howard, Ted K Ringsred, Robert W Sprague, August 29, 2000: US06110929 (166 worldwide citation)

Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and ...