1
John McWhirter, Lynn MacDonald, Andrew J Murphy: Mice that produce antigen-binding proteins with pH-dependent binding characteristics. Regeneron Pharmaceuticals, Brownstein Hyatt Farber Schneck, Rita S Wu, Yong Jin Choi, April 5, 2016: US09301510 (1 worldwide citation)

Genetically modified non-human animals are provided that comprise an immunoglobulin heavy chain locus comprising an unrearranged human heavy chain variable region nucleotide sequence comprising an addition of at least one histidine codon or a substitution of at least one endogenous non-histidine cod ...


2
Lynn MacDonald, Andrew J Murphy, Naxin Tu, Cagan Gurer, Vera Voronina, Sean Stevens: Genetically modified major histocompatibility complex animals. Regeneron Pharmaceuticals, Brownstein Hyatt Farber Schreck, Rita S Wu, Margarita Zippin, June 2, 2015: US09043996 (1 worldwide citation)

The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II α and β polypeptides), as well as embryos, cells, and tissues comprising the humanized MHC II protein. Also provided are constructs for and methods of making the genetically modifi ...


3
John McWhirter, Cagan Gurer, Karolina A Meagher, Lynn Macdonald, Andrew J Murphy: Non-human animals with modifed immunoglobulin heavy chain sequences. Regeneron Pharmaceuticals, Brownstein Hyatt Farber Schreck, Rita S Wu, Yong Jin Choi, December 8, 2015: US09204624 (1 worldwide citation)

Non-human animals, e.g., mammals, e.g., mice or rats, are provided comprising an immunoglobulin heavy chain locus that comprises a rearranged human immunoglobulin heavy chain variable region nucleotide sequence. The rearranged human immunoglobulin heavy chain variable region nucleotide sequence may ...


4
Lynn MacDonald, Andrew J Murphy, John McWhirter, Naxin Tu, Vera Voronina, Cagan Gurer, Karolina Meagher, Sean Stevens: Genetically modified mice having humanized TCR variable genes. Regeneron Pharmaceuticals, Brownstein Hyatt Farber Schreck, Rita S Wu, Margarita Zippin, August 25, 2015: US09113616 (1 worldwide citation)

The invention provides a genetically modified non-human animal that comprises in its genome unrearranged T cell receptor variable gene loci, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified non-human animal and methods of m ...


5
John McWhirter, Lynn Macdonald, Joel H Martin, Andrew J Murphy: Non-human animals expressing pH-sensitive immunoglobulin sequences. Regeneron Pharmaceuticals, Brownstein Hyatt Farber Schreck, Rita S Wu, Ilona Gont, October 31, 2017: US09801362

Genetically modified non-human animals are provided that express an immunoglobulin variable domain that comprises at least one histidine, wherein the at least one histidine is encoded by a substitution of a non-histidine codon in the germline of the animal with a hisidine codon, or the insertion of ...


6
John McWhirter, Lynn MacDonald, Joel H Martin, Andrew J Murphy: Non-human animals expressing pH-sensitive immunoglobulin sequences. Regeneron Pharmaceuticals, Brownstein Hyatt Farber Schreck, Rita S Wu, Ilona Gont, May 16, 2017: US09648856

Genetically modified non-human animals are provided that express an immunoglobulin variable domain that comprises at least one histidine, wherein the at least one histidine is encoded by a substitution of a non-histidine codon in the germline of the animal with a histidine codon, or the insertion of ...


7
John McWhirter, Lynn MacDonald, Andrew J Murphy: Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same. Regeneron Pharmaceuticals, Brownstein Hyatt Farber Schreck, Rita S Wu, Margarita Zippin, May 10, 2016: US09332742

A genetically modified non-human animal is provided, wherein the non-human animal expresses an antibody repertoire capable of pH dependent binding to antigens upon immunization. A genetically modified non-human animal is provided that expresses human immunoglobulin light chain variable domains deriv ...


8
John McWhirter, Lynn MacDonald, Andrew J Murphy: Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same. Regeneron Pharmaceuticals, Brownstein Hyatt Farber Schreck, Rita S Wu, Margarita Zippin, May 10, 2016: US09334334

A genetically modified non-human animal is provided, wherein the non-human animal expresses an antibody repertoire capable of pH dependent binding to antigens upon immunization. A genetically modified non-human animal is provided that expresses a single light chain variable domain derived from a sin ...


9
Andrew J Murphy, Lynn Macdonald, John McWhirter: Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same. Brownstein Hyatt Farber Schreck, Rita S Wu, Margarita Zippin, August 23, 2016: US09422370

A genetically modified non-human animal is provided, wherein the non-human animal expresses an antibody repertoire capable of pH dependent binding to antigens upon immunization. A genetically modified non-human animal is provided that expresses a single light chain variable domain derived from a sin ...


10
John McWhirter, Cagan Gurer, Karolina A Meagher, Lynn Macdonald, Andrew J Murphy: Non-human animals with modified immunoglobulin heavy chain sequences. Regeneron Pharmaceuticals, Rita S Wu, Ilona Gont, Elysa Goldberg, April 3, 2018: US09930871

Non-human animals, e.g., mammals, e.g., mice or rats, are provided comprising an immunoglobulin heavy chain locus that comprises a rearranged human immunoglobulin heavy chain variable region nucleotide sequence. The rearranged human immunoglobulin heavy chain variable region nucleotide sequence may ...