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Robert M Platz, Mark A Winters, Colin G Pitt: Pulmonary administration of granulocyte colony stimulating factor. Amgen, Richard J Mazza, February 8, 1994: US05284656 (188 worldwide citation)

Granulocyte-colony stimulating factor (G-CSF) can be delivered systemically in therapeutically or prophylactically effective amounts by pulmonary administration using a variety of pulmonary delivery devices, including nebulizers, metered dose inhalers and powder inhalers. Aerosol administration in a ...


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Thomas C Boone, William C Kenney: Stabilized hydrophobic protein formulations of G-CSF. Amgen, Henry P Nowak, Richard J Mazza, Daniel M Chambers, April 14, 1992: US05104651 (62 worldwide citation)

A stable pharmaceutically acceptable formulation containing a pharmaceutically acceptable amount of a protein is disclosed. Also disclosed are associated means and methods for preparing such formulations.


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Serge G J Chaumet: Method and apparatus for monitoring respiration. Kontron Holding, Jon S Saxe, Bernard S Leon, Richard J Mazza, July 19, 1988: US04757824 (48 worldwide citation)

A method and an apparatus are provided for monitoring waveforms representing the respiration of a patient and for detecting waveforms having characteristics indicative of apnea. The method comprises processing a first electrical signal having a waveform representing the respiration of the patient an ...


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Claude Borer, Andreas Greter: Cuvette. Hoffmann La Roche, Jon S Saxe, Bernard S Leon, Richard J Mazza, January 27, 1987: US04639135 (36 worldwide citation)

A cuvette arrangement for use in a chemical analysis system, which cuvette arrangement comprises an integrally constructed unit which defines separate chambers, for the receipt of sample-reagent mixtures.


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Olaf Boris Kinstler, Qiao Yan: BDNF and NT-3 polypeptides selectively linked to polyethylene glycol. Amgen, Richard J Mazza, Ron Levy, Steven M Odre, June 23, 1998: US05770577 (30 worldwide citation)

Derivatives of the neurotrophic factors BDNF and NT-3 have been prepared by attachment of these polypeptides to a water soluble polymer, for instance, polyethylene glycol.


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Alan D Habberfield, Olaf B Kinstler, Colin G Pitt: Conjugates of vitamin B12 and proteins. Amgen, Richard J Mazza, November 12, 1996: US05574018 (28 worldwide citation)

Therapeutically useful proteins are conjugated to vitamin B.sub.12 by covalent binding at the primary hydroxyl site of the ribose moiety. The resulting conjugates are biologically active and can be formulated into pharmaceutical compositions suitable for delivery by various routes of administration, ...


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Sharon Lea Aukerman, Glenn Francis Pierce: Method of treating diabetes mellitus using KGF. Amgen, Thomas D Zindrick, Richard J Mazza, Steven M Odre, January 12, 1999: US05858977 (27 worldwide citation)

A method and pharmaceutical compositions are described for the use of keratinocyte growth factor to treat diabetes mellitus in mammals.


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Geoffrey Lawton, Sally Redshaw: Pyridazodiazepine derivatives. Hoffman La Roche, Jon S Saxe, Bernard S Leon, Richard J Mazza, November 1, 1988: US04782149 (22 worldwide citation)

Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 each independently represent hydrogen, C.sub.1 -C.sub.10 -alkyl, adamantyl-(C.sub.1 -C.sub.4 -alkyl) or (C.sub.2 -C.sub.6 -alkanoyloxy)-(C.sub.1 -C.sub.4 -alkyl), and pharmaceutically acceptable salts thereof possess antihypertensive acti ...


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Paul Muller: Apparatus for withdrawing liquid from closed receptacle. Kontron Holding, Jon S Saxe, Bernard S Leon, Richard J Mazza, January 26, 1988: US04721137 (20 worldwide citation)

An apparatus for withdrawing liquid from a receptacle which is closed with a penetrable cover, which comprises a puncturing tool for creating an aperture in the receptacle cover, a cannula for entering the receptacle through the aperture and withdrawing liquid from the receptacle, a holding arm to w ...