1
David S Soane, Zoya M Soane: Method and device for moving molecules by the application of a plurality of electrical fields. Soane Biosciences, Richard F Trecartin, Flehr Hohbach Test Albritton & Herbert, May 12, 1998: US05750015 (337 worldwide citation)

Devices and methods are disclosed for moving charged molecules through a medium by the application of a plurality of electrical fields of sufficient strength and applied for sufficient amounts of time so as to move the charged molecules through the medium. The devices although preferably small in si ...


2
Gary Blackburn, Stephen E Creager, Scott Fraser, Bruce D Irvine, Thomas J Meade, Stephen D O&apos Connor, Robert H Terbrueggen, Jost G Vielmetter, Thomas W Welch: Binding acceleration techniques for the detection of analytes. Clinical Micro Sensors, Richard F Trecartin Esq, Robin M Silva Esq, Flehr Hohabch Test Albritton & Herbert, July 24, 2001: US06264825 (323 worldwide citation)

The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow elect ...


3
Thomas J Meade, Jon Faiz Kayyem, Scott E Fraser: Nucleic acid mediated electron transfer. California Institute of Technology, Richard F Trecartin, Robin M Silva, Flehr Hohbach Test Albritton & Herbert, June 23, 1998: US05770369 (233 worldwide citation)

The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The ...


4
Paulus J A Krimpenfort, Antonius J M Berns: Transgenic mice depleted in mature T-cells and methods for making transgenic mice. GenPharm International, Richard F Trecartin, December 29, 1992: US05175384 (151 worldwide citation)

Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the T lymphocyte which is depleted. The t ...


5
David J Anderson, Derek L Stemple: Mammalian neural crest stem cells. California Institute of Technology, Richard F Trecartin, Robin M Silva, Flehr Hohbach Test Albritton & Herbert, December 31, 1996: US05589376 (144 worldwide citation)

The invention includes methods for the isolation and clonal propagation of mammalian neural crest stem cells and isolated cellular compositions comprising the same. The methods employ a novel separation and culturing regimen and bioassays for establishing the generation of neural crest stem cell der ...


6
Thomas J Meade: Detection of analytes using reorganization energy. Clinical Micro Sensors, Richard F Trecartin Esq, Robin M Silva Esq, Flehr Hohbach Test Albritton & Herbert, January 11, 2000: US06013170 (143 worldwide citation)

The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, .lambda., of an electron transfer process.


7
David J Anderson, Derek L Stemple: Mammalian multipotent neural stem cells. California Institute of Technology, Richard F Trecartin, Robin M Silva, Flehr Hohbach Test Albritton & Herbert, December 15, 1998: US05849553 (123 worldwide citation)

The invention includes mammalian multipotent neural stem cells and their progeny and methods for the isolation and clonal propagation of such cells. At the clonal level the stem cells are capable of self regeneration and asymmetrical division. Lineage restriction is demonstrated within developing cl ...


8
Thomas M Brennan, Herbert L Heyneker: Methods and compositions for determining the sequence of nucleic acids. Richard F Trecartin, April 4, 1995: US05403708 (118 worldwide citation)

Methods and compositions for forming ligation product hybridized to a nucleic acid template. The ligation product is formed by contacting a nucleic acid template with a primer capable of hybridizing to the template to form a primed template. The primed template is then contacted with a pool of rando ...


9
Thomas J Meade, Jon F Kayyem, Scott E Fraser: Nucleic acid mediated electron transfer. California Institute of Technology, Richard F Trecartin, Robin M Silva, Flehr Hohbach Test Albritton & Herbert, January 7, 1997: US05591578 (114 worldwide citation)

The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of the nucleic acid at predetermined positions. T ...


10