1
Douglas L Cole, Robert T Goegelman: Method for the separation of antibiotic macrolides. Merck & Co, David L Rose, Richard A Thompson, Harry E Westlake, July 10, 1979: US04160861 (22 worldwide citation)

This case relates to a novel process which aids in the isolation and purification of novel compounds which are produced by the microorganism, Streptomyces avermitilis. The process described herein utilizes a high pressure liquid chromatographic system (HPLC) for the isolation and purification of the ...


2
William M Maiese, Richard G Wax: Antibiotic FR-02A and therapeutic compositions thereof. Merck & Co, Richard A Thompson, Walter Patton, Julian S Levitt, May 17, 1977: US04024251 (13 worldwide citation)

This invention relates to a new antibiotic agent which also possesses growth promoting activity. The antibiotic is isolated from the fermentation broth of Streptomyces lactamdurans by solvent extraction and designated Efrotomycin.


3
Richard F Shuman: Preparation of (3-trifluoromethylphenoxy)(4-chlorophenyl)acetonitrile. Merck & Co, Richard A Thompson, J Jerome Behan, April 27, 1976: US03953490 (10 worldwide citation)

A method for preparing 2-acetamidoethyl (3-trifluoromethylphenoxy)(4-chlorophenyl)acetate which comprises treating (3-trifluoromethylphenoxy)(4-chlorophenyl)acetonitrile with 2-acetamidoethanol in the presence of an acid to form an imino intermediate which, upon treatment with an aqueous solution, a ...


4
Robert T Goegelman, Frederick M Kahan: Process for purifying thienamycin. Merck & Co, Richard A Thompson, Walter Patton, Julian S Levitt, December 28, 1976: US04000161 (9 worldwide citation)

Fermentation broths or impure solutions containing thienamycin, a substance having antibiotic activity against gram-negative and gram-positive microorganisms, are purified using ion exchange resins, poly-acrylamide gels or adsorbents such as polyester polymers or polystyrene, hydrophobic crosslinked ...


5
Kenneth E Wilson, Thomas W Miller: Method for the separation and purification of antibiotic macrolides. Merck & Co, David L Rose, Richard A Thompson, Harry E Westlake, July 17, 1979: US04161583 (8 worldwide citation)

This case relates to a novel process which aids in the isolation and purification of novel compounds which are produced by the microorganism, Streptomyces avermitilis. The process described utilizes a non-aqueous extraction system for purifying crude extracts of the novel compounds. The compounds wh ...


6
Jean S Kahan, Frederick M Kahan, Edward O Stapley, Robert T Goegelman, Sebastian Hernandez: Thienamycin production. Merck & Co, Richard A Thompson, Walter Patton, Julian S Levitt, February 1, 1977: US04006060 (8 worldwide citation)

The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media.


7
Glenn R Elion, Arthur E Klink: Preparation of cyanopyridines. Merck & Co, Richard A Thompson, J Jerome Behan, July 20, 1976: US03970657 (6 worldwide citation)

Cyanopyridines are prepared by bringing a reactant stream comprising an alkyl substituted pyridine, ammonia, steam and oxygen into contact with a novel catalyst composition which results in high selectivity to the desired cyanopyridine.


8
Ian W Cottrell, Richard A Empey, Joseph S Racciato: Sulfomethylated graft copolymers of xanthan gum and polyacrylamide. Merck & Co, Donald J Perrella, Richard A Thompson, August 8, 1978: US04105605 (6 worldwide citation)

A water-soluble anionic graft copolymer of xanthan gum and polyacrylamide wherein at least part of the amide function is sulfomethylated.


9
Thomas W Miller, Kenneth E Wilson, Robert E Ormond: Method for the separation of antibiotic macrolides. Merck & Co, David L Rose, Richard A Thompson, Harry E Westlake, July 3, 1979: US04160084 (6 worldwide citation)

This case relates to a novel process which aids in the isolation and purification of novel compounds which are produced by the microorganism, Streptomyces avermitilis. The process described utilizes a column containing a hydroxyalkylated dextran gel as a step in the separation of the desired compoun ...


10
Glenn R Elion, Arthur E Klink: Preparation of cyanopyridines. Merck & Co, Richard A Thompson, J Jerome Behan, July 20, 1976: US03970659 (5 worldwide citation)

Cyanopyridines are prepared by bringing a reactant stream comprising an alkyl substituted pyridine, ammonia, steam and oxygen into contact with a novel catalyst composition which results in high selectivity to the desired cyanopyridine.