1
Hans J Hansen, Shui on Leung, Zhengxing Qu, David M Goldenberg: Internalizing anti-CD74 antibodies and methods of use. Immunomedics, Faegre & Benson, Richard A Nakashima, December 25, 2007: US07312318 (89 worldwide citation)

The present invention provides humanized, chimeric and human anti-CD74 antibodies, CD74 antibody fusion proteins, immunoconjugates, vaccines and bispecific that bind to CD74, the major histocompatibility complex (MHC) class-II invariant chain, Ii, which is useful for the treatment and diagnosis of B ...


2
Shaorong Liu: Microfabricated injector and capillary array assembly for high-resolution and high throughput separation. Richard A Nakashima, Blakely Sokoloff Taylor & Zafman, March 18, 2003: US06533914 (83 worldwide citation)

The present invention concerns methods and apparatus for the high resolution, high output electrophoretic separation of molecules. In preferred embodiments, the methods and apparatus are of use for DNA sequencing. The apparatus comprises a hybrid device, comprising a microfabricated chip injector at ...


3
Chien Hsing Chang, David M Goldenberg, William J McBride, Edmund A Rossi: Stably tethered structures of defined compositions with multiple functions or binding specificities. IBC Pharmaceuticals, Richard A Nakashima, April 21, 2009: US07521056 (73 worldwide citation)

The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first monomer, comprising a dimerization an ...


4
Chien Hsing Chang, David M Goldenberg, William J McBride, Edmund A Rossi: Methods and compositions for generating bioactive assemblies of increased complexity and uses. IBC Pharmaceuticals, Richard A Nakashima, May 19, 2009: US07534866 (72 worldwide citation)

The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In particular embodiments, the bioactive assembly is formed using dock-and-lock (DNL) methodology, which ta ...


5
Chien Hsing Chang, David M Goldenberg, Edmund A Rossi: Multivalent immunoglobulin-based bioactive assemblies. IBC Pharmaceuticals, Richard A Nakashima, May 5, 2009: US07527787 (71 worldwide citation)

The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Preferred embodiments concern hexameric stably tethered structures comprising one or more IgG antibody fragments and w ...


6
Chien Hsing Chang, David M Goldenberg, William J McBride, Edmund A Rossi: Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses. IBC Pharmaceuticals, Richard A Nakashima, June 23, 2009: US07550143 (70 worldwide citation)

The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular embodiments concern homodimers comprising monomers that contain a dimerization and docking domain attached ...


7
Chien Hsing Chang, David M Goldenberg, William J McBride, Edmund A Rossi: PEGylation by the dock and lock (DNL) technique. IBC Pharmaceuticals, Richard A Nakashima, February 23, 2010: US07666400 (68 worldwide citation)

The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using dock-and-lock technology, by attaching a therapeutic agent to a DDD sequence and attaching a PEG moiety to a ...


8
Serengulam V Govindan, David M Goldenberg, Sung Ju Moon: Camptothecin-binding moiety conjugates. Immunomedics, Richard A Nakashima, September 22, 2009: US07591994 (56 worldwide citation)

The invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a camptothecin as a therapeutic moiety, and further relates to processes for making and using the said conjuga ...


9
David M Goldenberg, Hans J Hansen, Shui on Leung: Chimeric, human and humanized anti-granulocyte antibodies and methods of use. Immunomedics, Richard A Nakashima, June 2, 2009: US07541440 (54 worldwide citation)

The present invention provides humanized, chimeric and human MN3 antibodies, fusion proteins, and fragments thereof. The antibodies, fusion proteins, and fragments thereof, as well as combinations with other suitable antibodies, are useful for the treatment and diagnosis of granulocyte related disor ...


10
Chien Hsing Chang, David M Goldenberg: Dock-and-lock (DNL) vaccines for cancer therapy. IBC Pharmaceuticals, Richard A Nakashima, March 8, 2011: US07901680 (44 worldwide citation)

The present invention concerns methods and compositions for forming anti-cancer vaccine DNL complexes using dock-and-lock technology. In preferred embodiments, the anti-cancer vaccine DNL complex comprises an antibody moiety that binds to dendritic cells, such as an anti-CD74 antibody or antigen-bin ...