31
Stovall Shawn E: Repair of intervertebral disks. Reprogenesis, Stovall Shawn E, POSORSKE Laurence H, February 4, 1999: WO/1999/004720

This invention is a method of using a cell containing hydrogel suspension for treating a herniated intervertebral disk (10) by implanting a cell suspension into a patient, thereby forming a cell containing hydrogel adherent to at least one surface of the annulus fibrosus (20) of the herniated disk ( ...


32
Allnutt F C Thomas, Kyle David, Grossman Arthur R, Apt Kirk: Methods and tools for transformation of eukaryotic algae. Martek Biosciences Corporation, Carnegie Institution Of Washington, Allnutt F C Thomas, Kyle David, Grossman Arthur R, Apt Kirk, POSORSKE Laurence H, October 23, 1997: WO/1997/039106

Genetic fusions for use in genetic engineering of eukaryotic algae employ a promoter from a light harvesting protein fused to a protein of interest. The fusions can be introduced and selected using an antibiotic resistance determinant. One gene useful for such selection is the $i(sh ble) gene encodi ...


33
Bringi Venkataraman, Kakrade Prakash G, Prince Christopher L, Roach Braden L: (taxus) Species. Phyton, Bringi Venkataraman, Kakrade Prakash G, Prince Christopher L, Roach Braden L, POSORSKE Laurence H, November 27, 1997: WO/1997/044476

This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known $i(Taxus) species, e.g., $i(brevifolia), $i(canadensis), $i(cuspidata), $i(baccata), $i(globosa), $i(floridana), $i(wallichiana), $i(media) and $ ...


34
Mohr Scott C, Ray Rahul: Photodynamic therapy using nuclear hormone receptors to target photosensitizers. Trustees Of Boston University, Mohr Scott C, Ray Rahul, POSORSKE Laurence H, September 25, 1997: WO/1997/034637

The present invention exploits a novel mechanism for photosensitizer localization, namely interaction with the high-affinity receptors which mediate the hormonal signals transmitted by steroids (and some other hormones such as thyroxine, retinoids, and members of vitamin D family). These receptors a ...


35
Borland Kermit M, Zhou Tao, Nelson Gordon P, Atala Anthony: Improved hydrogel composition. Reprogenesis, Children S Medical Center Corporation, POSORSKE Laurence H, June 18, 1998: WO/1998/025575

This invention provides compositions for use in implanting cells into an animal comprising cells (which may be dissociated cells and/or cell aggregates); a biodegradable, biocompatible polymer which forms a hydrogel upon cross-linking by multivalent ions; a soluble salt of a multivalent ion; and a s ...


36
Pasternack Gary R, Kuhajda Francis P: Novel mammalian protein associated with uncontrolled cell division. The Johns Hopkins University, POSORSKE Laurence H, April 4, 1996: WO/1996/010092

Three mammalian proteins are disclosed which are useful in the diagnosis and prognosis of tumors of lymphoid and epithelial origin. The three proteins are immunologically related to each other. The level of expression of the proteins correlates with the malignant potential of lymphoid and epithelial ...


37
Halberstadt Craig R, Holder Walter D Jr: Creation of three-dimensional tissues. Charlotte Mecklenberg Hospital Authority, Halberstadt Craig R, Holder Walter D Jr, POSORSKE Laurence H, October 21, 1999: WO/1999/052356

A method of providing a vascularized, three-dimensional tissue in a living subject is disclosed. The method includes the steps of (a) creating, from a biocompatible material capable of supporting cell adhesion, growth, and migration, a porous construct containing cells to be transplanted, and (b) de ...


38
Pasternack Gary R, Bai Jining: Method of treating cancer by restoration of pp32 function. The Johns Hopkins University, Pasternack Gary R, Bai Jining, POSORSKE Laurence H, August 10, 2000: WO/2000/045852

Methods to treat existing cancer or prevent cancer formation by restoration of pp32 function in cells lacking normal pp32 activity or expression are provided. The methods provide for restoration of pp32 either through transfection of cells with DNA expressing normal pp32, administration of an induce ...


39
Chacon Marco A: Therapeutic intervention to mimic the effect of caloric restriction. Chacon Marco A, POSORSKE Laurence H, May 31, 2001: WO/2001/037827

Methods are provided for promoting longevity and decreasing the incidence of aging associated pathologies (e.g., cancer) by the administration of one or more of the following LFFA: linoleic, oleic and palmitic acid. Secondary LFFA derived from this set, as well as their CoA derivatives and synthetic ...


40
Gladue Raymond M, Behrens Paul W: Dha-containing nutritional compositions and methods for their production. Martek Biosciences Corporation, Gladue Raymond M, Behrens Paul W, POSORSKE Laurence H, February 11, 1999: WO/1999/006585

This invention provides a particulate material suitable for use as a nutritional supplement, particularly as an aquaculture feed. The particulate material has a high proportion of DHA residues in the lipid fraction, which may be up to 35% of the material, or even more. Preferably, the material has a ...