1
Stephen G Spanton, Rodger F Henry, David A Riley, Jih Hua Liu: Crystal form O of clarithromycin. Abbott Laboratories, Portia Chen, Mona Anand, August 31, 1999: US05945405 (29 worldwide citation)

The present invention concerns the novel antiobiotic 6-O-methylerythromycin A form O solvate, a process for its preparation, pharmaceutical compositions comprising this compound and a method of use as a therapeutic agent.


2

3
Kent Abrahamson, Amy N Anderson, Haiyan Grady: Low oxygen content compositions of 1.alpha., 25-dihydroxycholecalciferol. Abbott Laboratories, Portia Chen, Gregory W Steele, April 18, 2000: US06051567 (21 worldwide citation)

The invention relates to stable aqueous formulations comprising 1.alpha., 25-dihydroxycholecalciferol, a unit dose system comprising the same in a sealed vessel, and a process for preparing them.


4
Jianguo Ji, Tao Li: Fused bicycloheterocycle substituted quinuclidine derivatives. Abbott Laboratories, Portia Chen, January 9, 2007: US07160876 (20 worldwide citation)

Compounds of formula (I) wherein n is 0, 1, or 2; X is O, S, —NH—, and —N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical ...


5

6
Yi Yin Ku, David A Riley, Elaine C Lee, Jien Heh Tien: Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives. Abbott Laboratories, Portia Chen, Mona Anand, April 6, 1999: US05892008 (20 worldwide citation)

The claimed invention provides a novel method of preparing 6-O-methyl erythromycin A. The process comprises the steps of reducing the 9-keto group of erythromycin A to form a 9-hydroxy erythromycin A, protecting the 9-, 2'-, and/or 4"-hydroxyl groups of erythromycin A, selectively methylating the 6- ...


7
Jih Hua Liu, Stephen H Montgomery: Process for preparing 6-O-alkyl-9-oxime erythromycin B. Abbott Laboratories, Portia Chen, Mona Anand, August 3, 1999: US05932710 (18 worldwide citation)

A process of preparing a 6-O-alkyl derivative of 9-oxime erythromycin B is provided. Intermediates used in the preparation of a 6-O-alkyl 9-oxime erythromycin B are also provided. Pharmaceutical compositions containing a 6-O-alkyl derivative of 9-oxime erythromycin B and the use of those composition ...


8
Yat Sun Or, Zhenkun Ma, Richard F Clark, Daniel T Chu, Jacob J Plattner, George Griesgraber: 6-0-Substituted antibacterial erythromycin ketolides and methods of making. Abbott Laboratories, Mona Anand, Portia Chen, February 22, 2000: US06028181 (17 worldwide citation)

Antimicrobial compounds having the formula ##STR1## as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of ...


9
H Eugene Gracey, Stephen H Montgomery, David A Riley, Jih Hua Liu: 6-O-alkyl derivatives of erythronolide B. Abbott Laboratories, Portia Chen, Mona Anand, July 6, 1999: US05919916 (17 worldwide citation)

Novel 6-O-alkyl derivatives of erythronolide B are provided. A process for the preparation of 6-O-alkyl derivatives of erythronolide B using erythromycin B is also provided. A process for preparing 6-O-alkyl derivatives of erythromycin C using novel 6-O-alkyl derivatives of erythronolide B is furthe ...


10
Yat Sun Or, Zhenkun Ma, Richard F Clark, Daniel T Chu, Jacob J Plattner, George Griesgraber: 6-O-substituted antibacterial erythromycin ketolides and methods of making. Abbott Laboratories, Mona Anand, Portia Chen, June 13, 2000: US06075133 (16 worldwide citation)

Antimicrobial compounds having the formula as well as pharmaceutically acceptable sats, esters or prodrugs thereof, pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compou ...