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Zhou Yuefen, Vourloumis Dionisios, Gregor Vlad E, Winters Geoff, Hermann Thomas, Ayida Benjamin, Sun Zhongxiang, Murphy Douglas, Simonsen Klaus Baek: Antibacterial 3,5-diaminopiperidine-substitute aromatic and heteroaromatic compounds. Anadys Pharmaceuticals, Zhou Yuefen, Vourloumis Dionisios, Gregor Vlad E, Winters Geoff, Hermann Thomas, Ayida Benjamin, Sun Zhongxiang, Murphy Douglas, Simonsen Klaus Baek, PINO Mark J, March 31, 2005: WO/2005/028467 (34 worldwide citation)

The invention relates to antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds and pharmaceutical compositions thereof. This invention also relates to a method of using such compounds in the treatment of bacterial infections in mammals, especially humans.


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DRAGOVICH PETER S: A method of inhibiting hepatitis c virus by combination of a 5,6-dihydro-1h-pyridin-2-one and one or more additional antiviral compounds. ANADYS PHARMACEUTICALS, Pino Mark J, April 15, 2010: WO/2010/042834 (27 worldwide citation)

The invention is directed to a method of treating infections by hepatitis C virus by administering N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1 -dioxo-l,4-dihydro-lλ6- benzo[l,2,4]thiadiazin-7-yl} -methanesulfonamide and one or more additiona ...


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Averett Devron R: Tlr7 ligands for the treatment of hepatitis c. Anadys Pharmaceuticals, Averett Devron R, PINO Mark J, March 24, 2005: WO/2005/025583 (20 worldwide citation)

This invention relates to methods for treating or preventing hepatitis C virus infections in mammals using Toll-Like Receptor (TLR)7 ligands and prodrugs thereof. More particularly, this invention relates to methods of orally administering a therapeutically effective amount of one or more prodrugs o ...


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Smith Adrian Leonard, Brennan Paul Edward, Demorin Frenel Fils, Liu Gang, Paras Nick A, Retz Daniel Martin: Aminopyrimidine compounds and methods of use. Amgen, Smith Adrian Leonard, Brennan Paul Edward, Demorin Frenel Fils, Liu Gang, Paras Nick A, Retz Daniel Martin, PINO Mark J, June 22, 2006: WO/2006/066172 (20 worldwide citation)

The invention relates to aminopyrimidine compounds useful for treating diseases mediated by polo-like kinase 1 (Plk1). The invention also relates to the therapeutic use of such aminopyrimidine compounds and compositions thereof in treating disease states associated with abnormal cell growth and unwa ...


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Zhou Yuefen, Li Liansheng, Webber Stephen E: Pyridazinone compounds. Anadys Pharmaceuticals, Zhou Yuefen, Li Liansheng, Webber Stephen E, PINO Mark J, June 22, 2006: WO/2006/066079 (10 worldwide citation)

The invention is directed to pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.


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Webber Stephen E, Haley Gregory J, Lennox Joseph R, Xiang Alan Xin, Rueden Erik J: 3, 5-disubstituted and 3,5,7-trisubstituted-3h-oxazolo and 3h-thiazolo [4,5-d]pyrimidin-2-one compounds and prodrugs thereof. Anadys Pharmaceuticals, Webber Stephen E, Haley Gregory J, Lennox Joseph R, Xiang Alan Xin, Rueden Erik J, PINO Mark J, June 22, 2006: WO/2006/066080 (7 worldwide citation)

The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3-H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and pharmaceutical com ...


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Gallou Fabrice, Beney Pascal: Semi-continuous and continuous enzymatic hydrolysisprocess. Anadys Pharmaceuticals, Gallou Fabrice, Beney Pascal, PINO Mark J, December 31, 2008: WO/2009/003042 (7 worldwide citation)

The present invention relates to an semi-continuous or continuous process process for the regioselective enzymatic hydrolysis of alcohol groups protected e.g. as esters or amino-acid esters or phosphate groups The process of the present invention is useful for instance for the selective enzymatic hy ...


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Xu Weizheng, Delahanty Greg, Wei Ling, Zhang Jie: Parp inhibitor compounds, compositions and methods of use. Mgi Gp, Xu Weizheng, Delahanty Greg, Wei Ling, Zhang Jie, PINO Mark J, April 9, 2009: WO/2009/046205 (4 worldwide citation)

The present invention relates to tetraaza phenalen-3-one compounds which inhibit poly (ADP-ribose) polymerase (PARP) and are useful in the chemosensitization of cancer therapeutics. The induction of peripheral neuropathy is a common side-effect of many of the conventional and newer chemotherapies. T ...


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Chu Shao Song, Alegria Larry Andrew, Bender Steven Lee, Benedict Suzanne Pritchett, Borchardt Allen J, Kania Robert Steven, Nambu Mitchell David, Tempczyk Russell Anna Maria, Sarshar Sepehr, Bhumralkar Dilip, Peng Zhengwei, Yang Yi Michelle: Diaminothiazoles and their use for inhibiting protein kinases. Agouron Pharmaceuticals, PINO Mark J, December 14, 2000: WO/2000/075120 (4 worldwide citation)

Diaminothiazole compounds of formula (I) that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell ...