1
Balkrishen Bhat, Neelima Bhat, Anne B Eldrup, Thazha P Prakash, Marija Prhavc, Quanlai Song, Phillip Dan Cook, Steven S Carroll, Malcolm Maccoss, David B Olsen: Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase of hepatitis C virus. Merck & Co, Isis Pharmaceuticals, Philippe L Durette, Melvin Winokur, August 17, 2004: US06777395 (141 worldwide citation)

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are partic ...


2
Scott D Edmondson, Michael H Fisher, Dooseop Kim, Malcolm Maccoss, Emma R Parmee, Ann E Weber, Jinyou Xu: Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes. Merck & Co, Philippe L Durette, Melvin Winokur, J Eric Thies, March 2, 2004: US06699871 (126 worldwide citation)

The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. T ...


3
Steven S Carroll, David B Olsen, Malcolm MacCoss, Balkrishen Bhat, Phillip Dan Cook, Anne B Eldrup, Thazha P Prakash: Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase. Merck & Co, Isis Pharmaceuticals, Philippe L Durette, Melvin Winokur, September 12, 2006: US07105499 (105 worldwide citation)

The present invention provides nucleoside derivatives which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of ...


4
Balkrishen Bhat, Neelima Bhat, Anne B Eldrup, Thazha P Prakash, Marija Prhavc, Quanlai Song, Phillip Dan Cook, Steven S Carroll, Malcolm Maccoss, David B Olsen: Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase. Merck & Co, Philippe L Durette, Melvin Winokur, October 24, 2006: US07125855 (103 worldwide citation)

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are partic ...


5
Anne B Eldrup, Marija Prhavc, Phillip Dan Cook, Steven S Carroll, David B Olsen: Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase. Merck & Co, ISIS Pharmaceuticals, Philippe L Durette, Melvin Winokur, April 10, 2007: US07202224 (96 worldwide citation)

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are partic ...


6
Maccoss Malcolm, Olsen David B, Leone Joseph, Durette Philippe L: Fluorinated pyrrolo[2,3-d]pyrimidine nucleosides for the treatment of rna-dependent rna viral infection. Merck & Co, Maccoss Malcolm, Olsen David B, Leone Joseph, Durette Philippe L, MERCK 126 East Lincoln Avenue Philippe L Durette Rahway NJ 07065 0907, June 22, 2006: WO/2006/065335 (55 worldwide citation)

The present invention provides fluorinated pyrrolo[2,3,d]pyrimidine nucleoside compounds which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are p ...


7
Malcolm MacCoss, David B Olsen, Monica Donghi, Cristina Gardelli, Steven Harper, Malte Meppen, Frank Narjes, Barbara Pacini: Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection. Merck Sharp & Dohme, Istituto di Ricerche di Biologia Molecolare P Angeletti S p A, Kenneth R Walton, Sheldon O Heber, Philippe L Durette, February 1, 2011: US07879815 (44 worldwide citation)

The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RN ...


8
Jason Matthew Elliott, Angus Murray MacLeod, Graeme Irvine Stevenson: Serine derivatives and their use as therapeutic agents. Merck Sharp & Dohme, Philippe L Durette, Melvin Winokur, March 23, 1999: US05885999 (43 worldwide citation)

The present invention relates to compounds of formula (I): ##STR1## wherein m is zero, 1 or 2; and n is zero or 1, with the proviso that the sum total of m+n is 1 or 2;


9
Raman K Bakshi, Khaled J Barakat, Ravi P Nargund, Brenda L Palucki, Arthur A Patchett, Iyassu Sebhat, Zhixiong Ye, Leonardus H T Van Der Ploeg: Substituted piperidines as melanocortin-4 receptor agonists. Merck & Co, Philippe L Durette, Melvin Winokur, February 26, 2002: US06350760 (38 worldwide citation)

Certain novel substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the a ...


10
David B Olsen, Robert L LaFemina, Anne B Eldrup, Sanjib Bera: Methods of inhibiting orthopoxvirus replication with nucleoside compounds. Merck & Co, Isis Pharmaceuticals, Kenneth R Walton, Philippe L Durette, Sheldon O Heber, January 29, 2008: US07323453 (36 worldwide citation)

The present invention provides methods of inhibiting orthopoxvirus replication and/or treating orthopoxvirus infection with certain nucleoside compounds and derivatives thereof. These compounds are particularly useful as inhibitors of vaccinia virus and variola virus replication and/or for the treat ...