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Lee Funk
Jingrong Jean Cui, Lee Andrew Funk, Lei Jia, Pei Pei Kung, Jerry Jialun Meng, Mitchell David Nambu, Mason Alan Pairish, Hong Shen, Michelle Tran Dube: Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors. Agouron Pharmaceuticals, Pfizer, December 23, 2010: US20100324061-A1

Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.


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Lee Funk
Lee Andrew Funk, Mary Catherine Johnson, Pei Pei Kung, Zhongxiang Zhou: Amide resorcinol compounds. Pfizer, Pfizer, August 27, 2009: US20090215742-A1

The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as HSP-90 inhibitors.


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Hong Liang, Yasmina Noubia Abdiche, Javier Fernando Chaparro Riggers, Bruce Charles Gomes, Julie Jia Li Hawkins, Jaume Pons, Yuli Wang: Isolated antibody which specifically binds to PCSK9. Rinat Neuroscience, Pfizer, Pfizer, December 20, 2011: US08080243 (51 worldwide citation)

The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method ...


4
Wenge Wang, Yen Tung Luan: Glycolysis-inhibiting substances in cell culture. Wyeth, Pfizer, June 5, 2012: US08192951 (40 worldwide citation)

An improved system for large scale production of proteins and/or polypeptides in cell culture is provided. In accordance with the present invention, cells expressing the protein or polypeptide of interest are grown in media that comprise a glycolysis-inhibiting substance. Additionally and/or alterna ...


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Hong Liang, Yasmina Noubia Abdiche, Javier Fernando Chaparro Riggers, Bruce Charles Gomes, Julie Jia Li Hawkins, Jaume Pons, Yuli Wang: Method for reducing a level of LDL-cholesterol by an antibody that specifically binds to PCSK9. Rinat Neuroscience, Pfizer, Pfizer, April 23, 2013: US08426363 (38 worldwide citation)

The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method ...


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Hong Liang, Yasmina Noubia Abdiche, Javier Fernando Chaparro Riggers, Bruce Charles Gomes, Julie Jia Li Hawkins, Jaume Pons, Yuli Wang: Isolated nucleic acid encoding an antibody which specifically binds to PCSK9 and a host cell that produces the antibody. Rinat Neuroscience, Pfizer, Pfizer, March 19, 2013: US08399646 (37 worldwide citation)

The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method ...


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Amy Mae Bunker, William Glen Harter, James Lester Hicks, Patrick Michael O Brien, Ly Pham, Joseph Armand Picard, William Howard Roark: Phenylene alkyne matrix metalloproteinase inhibitors. Warner Lambert Company, Pfizer, Claude F Purchase Jr, February 1, 2005: US06849648 (14 worldwide citation)

A compound of Formula I or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein G1, G2, and B are as defined in the application, are selective inhibitors of MMP-13. The compounds are useful for treating diseases mediated by MMP-13, including cancer and arthritis.


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Arnon Rosenthal, Jaume Pons, Wei Hsien Ho, Jan Markus Grimm: Antibodies directed against amyloid-beta peptide. Rinat Neuroscience, Pfizer, April 19, 2011: US07927594 (10 worldwide citation)

Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impai ...