1
Peter C Cheeseman: Method for sequencing polynucleotides. Beckman Instruments, William H May, P R Harder, Janis C Henry, April 12, 1994: US05302509 (453 worldwide citation)

A method is provided for determining the sequence of nucleotides on a single strand DNA molecule. The single strand DNA molecule is attached to a leader oligonucleotide and its complementary strand to a solid state support. Fluorescently-labeled 3'-blocked nucleotide triphosphates, with each of the ...


2
Leland B Smith: Bioelectrical impedance measuring system. Beckman Instruments, R J Steinmeyer, P R Harder, July 27, 1976: US03971365 (207 worldwide citation)

A bioelectrical impedance measuring system that measures and indicates the impedance of a biological subject, such as one or more human extremities. The system measures and indicates a basal impedance value of the measured subject, and also indicates short temporal variations in the basal value. In ...


3
Robert S Matson, Peter J Coassin, Jang B Rampal, Edwin M Southern: Method and apparatus for creating biopolymer arrays on a solid support surface. Beckman Instruments, William H May, P R Harder, Janis C Henry, July 4, 1995: US05429807 (181 worldwide citation)

An automated method and apparatus for performing biopolymer synthesis on a two-dimensional support surface whereby a two-dimensional matrix or array of biopolymers are obtained on the surface. An applicator in the form of a thick plate having in a surface at least one cavity in the form of an open c ...


4
Dale R Pfost, Torleif O Bjornson, Robert M Coppock, Carl Kowalski, Samuel A Marquiss, Donald S Murray, R Fred Pfost, Brian Sanford, Katherine L Puckett: Automated multi-purpose analytical chemistry processing center and laboratory work station. Beckman Instruments, William H May, P R Harder, Wen Liu, April 28, 1992: US05108703 (85 worldwide citation)

An automated multi-purpose analytical chemistry processing center and laboratory work station having a movable table for supporting microtiter plates and other fluid receptacles, a movable arm, and a modular mobile pod affixed for reciprocal movement along the arm. The work station combines into a s ...


5
Gregory Dzula, Melvin Levine, Elmer Ambrose Sperry III: Fluid sampling apparatus. Beckman Instruments, R J Steinmeyer, P R Harder, D A Streck, April 19, 1977: US04018089 (84 worldwide citation)

Improved apparatus for bringing a fluid in a process stream in contact with a sensor is disclosed. The present invention uses the kinetic energy of the process fluid to convey some of the fluid to and from the sensor, as opposed to the prior art practice of inserting the sensor itself into the proce ...


6
Peter J Coassin, Kenneth D Konrad, Jang B Rampal, Ronald M Cook: Inverse linkage oligonucleotides for chemical and enzymatic processes. Beckman Instruments, William H May, P R Harder, Janis C Henry, October 31, 1995: US05462854 (68 worldwide citation)

Inverse Linkage Oligonucleotides ("ILO") useful in enzymatic process are disclosed. Particularly preferred ILOs are amenable to enzymatic elongation from either, or most preferably, both termini. In a particularly preferred embodiment, each terminus of an ILO has an enzymatically functional 3' group ...


7
Parameswara M Reddy, Naeem B Hanna: N.sup.4 - acylated cytidinyl compounds useful in oligonucleotide synthesis. Beckman Instruments, William H May, P R Harder, Janis C Henry, June 27, 1995: US05428148 (64 worldwide citation)

Disclosed herein are protecting groups for exocyclic amino groups of the bases adenine, guanine and cytosine for use in the synthesis of oligonucleotides, the protecting groups being represented by the formula: --CO-- (CH.sub.2).sub.0-9 --CH.sub.3. In a particularly preferred embodiment, the base cy ...


8
Ronald G Porter, Richard E LeBlanc, Rolf W Siemon: Digital communication system for remote instruments. Beckman Instruments, R J Steinmeyer, P R Harder, E C Jason, November 1, 1983: US04413250 (63 worldwide citation)

A communication system for communicating digitally encoded information from a remote transmitting station to a central receiving station. The central station supplies d-c operating power to a remote station through a d-c power distribution line. A voltage regulator at the remote station receives the ...


9
Jack D McNeal, Michael L Bell: Axial spin blood separation system and method. Beckman Instruments, William H May, P R Harder, Steven G Roeder, December 29, 1998: US05853600 (56 worldwide citation)

A method for rapid separation of serum or plasma from cells in a whole blood sample uses a cylindrical sample tube having longitudinally-extending internal ribs. A separation gel and the sample are introduced into the tube, and the tube is axially centrifuged so as to form concentric shells of cells ...


10
Wilbur I Kaye: Marking and authenticating documents with liquid crystal materials. Beckman Instruments, W H May, P R Harder, S R Markl, April 30, 1985: US04514085 (54 worldwide citation)

Method and apparatus for authenticating documents such as government notes and currency, stock certificates, and the like by marking the document with an encapsulated dyed liquid crystal material and examining the document for unique optical characteristics of the mark. Reading apparatus for the doc ...