1
Audino Podda, Nicola Groth, Michele Pellegrini: Adjuvanted influenza vaccines for pediatric use. Novartis, Helen Lee, Otis Littlefield, August 13, 2013: US08506966 (33 worldwide citation)

An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared to an existing unadjuvanted pediatric influenza vaccine, the adjuvanted vaccines provided herein can induce in children a longer persistence ...


2
Astrid Borkowski: Multiple vaccination including serogroup C meningococcus. Novartis Vaccines and Diagnostics, Helen Lee, Otis Littlefield, May 21, 2013: US08444992 (29 worldwide citation)

Various improvements to vaccines that include a serogroup C meningococcal conjugate antigen, including: (a) co-administration with acellular B. pertussis antigen; (b) co-administration with an inactivated poliovirus antigen; (c) supply in a kit together with a separate pneumococcal conjugate compone ...


3
Marzia Monica Giuliani, Mariagrazia Pizza, Rino Rappuoli: Combination neisserial compositions. Novartis Vaccines and Diagnostics, Amy Hessler, Otis Littlefield, January 4, 2011: US07862827 (26 worldwide citation)

Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids. Preferred Neisseria species are N. meningitidis and N. gonorrhoeae.


4
Mariagrazia Pizza, Rino Rappuoli, Marzia Monica Giuliani: serogroup B outer membrane proteins, Outer membrane vesicle (OMV) vaccine comprising. Novartis, Amy Hessler, Otis Littlefield, September 25, 2012: US08273360 (26 worldwide citation)

A composition comprising (a) Neisseria meningitidis serogroup B outer membrane vesicles (OMVs), and (b) an immunogenic component selected from other Neisseria proteins, or immunogenic fragments thereof. Component (b) preferably includes a protein from a different NmB strain from that from which the ...


5
Mario Contorni, Lorenzo Tarli: Adjuvanting meningococcal factor H binding protein. Novartis, Amy Hessler, Otis Littlefield, March 19, 2013: US08398988 (22 worldwide citation)

Factor H binding protein (fHBP) has been proposed for use in immunising against serogroup B meningococcus (‘MenB’). This antigen can be efficiently adsorbed to an aluminum hydroxyphosphate adjuvant by (i) ensuring that adsorption takes place at a pH which is equal to or below the adjuvant's point of ...


6
Cesira Galeotti, Guido Grandi, Vega Masignani, Mariarosa Mora, Mariagrazia Pizza, Rino Rappuoli, Guilio Ratti, Vincenzo Scarlato, Maria Scarselli: Neisserial antigenic peptides. Novartis, Amy Hessler, Otis Littlefield, March 12, 2013: US08394390 (20 worldwide citation)

This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto e.g., antisense n ...


7
Vega Masignani, Maria Scarselli, Rino Rappuoli, Mariagrazia Pizza, Marzia Monica Giuliani: Chimeric, hybrid and tandem polypeptides of meningococcal NMB1870. Novartis, Amy Hessler, Otis Littlefield, March 19, 2013: US08398999 (16 worldwide citation)

NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding posi ...


8
Vega Masignani, Maria Scarselli, Rino Rappuoli, Mariagrazia Pizza, Marzia Monica Giuliani: Chimeric, hybrid and tandem polypeptides of meningococcal NMB1870. Novartis, Amy Hessler, Otis Littlefield, July 24, 2012: US08226960 (15 worldwide citation)

NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding posi ...


9
Vincenzo Scarlato, Vega Masignani, Rino Rappuoli, Mariagrazia Pizza, Guido Grandi: Neisserial antigens. Novartis, Amy Hessler, Otis Littlefield, October 23, 2012: US08293251 (14 worldwide citation)

The invention provides proteins from Neisseria meningitidis (strains A & B) and from Neisseria gonorrhoeae, including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or d ...


10
Mariagrazia Pizza: Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages. Novartis, Amy Hessler, Otis Littlefield, March 4, 2014: US08663656 (8 worldwide citation)

A small number of defined antigens can provide broad protection against meningococcal infection, and the invention provides a composition which, after administration to a subject, is able to induce an antibody response in that subject, wherein the antibody response is bactericidal against two or thr ...



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