Keiji Iwasaki, Yuji Iwashita, Taketoshi Okami: Hemoglobin combined with a poly(alkylene oxide). Ajinomoto Co, Oblon Fisher Spivak McClelland & Maier, June 2, 1987: US04670417 (537 worldwide citation)

There is disclosed hemoglobin modified in that a poly(alkylene oxide) is bonded thereto by a bond between a terminal group of said poly(alkylene oxide) and an amino group of said hemoglobin, said bond having the structure:

Yuji Iwashita, Katsumi Ajisaka: Blood substitute containing modified hemoglobin. Ajinomoto Company Incorporated, Oblon Fisher Spivak McClelland & Maier, November 17, 1981: US04301144 (414 worldwide citation)

A novel modified hemoglobin was prepared. The hemoglobin is coupled with a polyalkylene glycol or its derivative, and the products are useful as a blood substitute. The oxygen-carrying capacity of this hemoglobin is nearly equal to that of a native hemoglobin, and the residence time in the circulati ...

Fusayoshi Masuda, Kazuo Nishida, Akira Nakamura: Water absorbing starch resins. Sanyo Chemical, Oblon Fisher Spivak McClelland & Maier, February 28, 1978: US04076663 (407 worldwide citation)

A highly water-absorbent resin is produced by polymerizing (A) starch or cellulose, (B) at least one monomer having a polymerizable double bond which is water-soluble or becomes water-soluble by hydrolysis and (C) a crosslinking agent, and subjecting, if necessary, the resulting product to hydrolysi ...

Katsumi Niki, Katsuyoshi Kobayashi, Hiroo Inoguchi, Tatsuhiko Yagi: Chemically modified electrodes and their uses. Ajinomoto Company Incorporated, Oblon Fisher Spivak McClelland & Maier, October 28, 1986: US04619754 (384 worldwide citation)

An electrically conducting solid electrode having a surface on which a nitrogen-containing electron mediator and a strong acidic cation exchange resin containing aromatic groups are immobilized is disclosed along with methods for producing this electrode and uses therefor.

Kimihiro Shimizu, Tsuguji Nakahara, Taketoshi Kinoshita, Jun Takatsuka, Michiko Igarashi: Plasminogen activator derivatives. Nippon Chemiphar Company, Oblon Fisher Spivak McClelland & Maier, February 3, 1987: US04640835 (341 worldwide citation)

Derivatives of a nonimmunogenic plasminogen activator which comprises at least one polyalkylene glycol group chemically bonded with at least one coupling agent to amino acid side chains of said plasminogen activator, wherein said polyalkylene glycol has a molecular weight of about 200-20,000 and is ...


Yasuhiro Kimura, Katsumi Niki: Modified electrode. Ajinomoto Co, Oblon Fisher Spivak McClelland & Maier, June 17, 1986: US04595479 (320 worldwide citation)

A chemically modified electrode comprising a pyrolytic graphite surface, wherein the basal plane of graphite is exposed on said surface and a redox/adsorption electron mediator is irreversibly absorped directly onto the basal plane of graphite on said surface, is disclosed along with methods of usin ...

Shuichi Suzuki, Masuo Aizawa, Masao Koyama, Yuichi Sato, Junji Koezuka: Electrochemical measuring apparatus provided with an enzyme electrode. Tokyo Shibaura Denki Kabushiki Kaisha, Oblon Fisher Spivak McClelland & Maier, June 14, 1983: US04388166 (299 worldwide citation)

An electrochemical measuring apparatus which essemtially comprises an asymmetric semipermeable membrane mounted on an immobilized enzyme membrane of an enzyme electrode, said asymmetric semipermeable membrane being essentially formed of a thin semipermeable layer exposed to the outside for contact w ...

Paul Gauselmann: Slot machine. ADP Automaten, Oblon Fisher Spivak McClelland & Maier, April 15, 1980: US04198052 (296 worldwide citation)

A slot machine with at least three coaxially disposed wheels having a plurality of playing symbols on the peripheries thereof, wherein a plurality of columns of windows, one column for each window, are disposed in front of the wheels to enable viewing of a preselected number of symbols of each wheel ...

Thomas R Tice, Danny H Lewis: Microencapsulation process. Stolle Research and Development Corporation, Oblon Fisher Spivak McClelland & Maier, June 21, 1983: US04389330 (273 worldwide citation)

Microcapsules laden with an active agent are prepared by a method comprising: (a) dissolving or dispersing an active agent in a solvent and dissolving a wall forming material in said solvent; (b) dispersing said solvent containing said active agent and wall forming material in a continuous-phase pro ...