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Goodwin Neal Clifford, Endert Gerold, Herzog Natalie, Kerwitz Yvonne, Panzner Steffen, Rodrigueza Wendi: Amphoteric liposome formulation. Pronai Therapeutics, Goodwin Neal Clifford, Endert Gerold, Herzog Natalie, Kerwitz Yvonne, Panzner Steffen, Rodrigueza Wendi, O BRIEN Jonathan P, June 7, 2007: WO/2007/064857 (5 worldwide citation)

The invention relates to compositions and methods to inhibit gene expression. In particular, the invention provides DNAi oligonucleotides sequestered by amphoteric liposomes for the treatment of cancer.


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AREKAR SNEHA G: Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide. VERTEX PHARMACEUTICALS INCORPORATED, O Brien Jonathan P, September 22, 2011: WO/2011/116397 (5 worldwide citation)

The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.


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Sheikhnehjad Gholamreza, Sooch Mina Patel, Goodwin Neal, Olson David: Methods and compositions for the inhibition of gene expression. Pronai Therapeutics, Sheikhnehjad Gholamreza, Sooch Mina Patel, Goodwin Neal, Olson David, O BRIEN Jonathan P, December 15, 2005: WO/2005/118824 (5 worldwide citation)

The present invention relates to methods and compositions for the inhibition of gene expression. In particular, the present invention provides oligonucleotide-based therapeutics for the inhibition of oncogenes involved in cancers.


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VAN GOOR Fredrick F, ALARGOVA Rossitza Gueorguieva, ALCACIO Tim Edward, BINCH Hayley Marie, BOTFIELD Martyn Curtis, FANNING Lev Tyler Dewey, GROOTENHUIS Peter Diederik Jan, HURLEY Dennis James, KADIYALA Irina Nikolaevna, KAUSHIK Ritu Rohit, KESHAVARZ SHOKRI Ali, KRAWIEC Mariusz, LEE Elaine Chungmin, LUISI Brian, MEDEK Ales, NUMA Mehdi, SHETH Urvi Jagdishbhai, SILINA Alina, VERWIJS Marinus Jacobus, YANG Xiaoqing, YOUNG Christopher Ryan, ZAMAN Noreen Tasneem, ZHANG Beili, ZHANG Yuegang, ZLOKARNIK Gregor: Compositions pharmaceutiques et leurs administrations, Pharmaceutical compositions and administrations thereof. Vertex Pharmaceuticals Incorporated, VAN GOOR Fredrick F, ALARGOVA Rossitza Gueorguieva, ALCACIO Tim Edward, BINCH Hayley Marie, BOTFIELD Martyn Curtis, FANNING Lev Tyler Dewey, GROOTENHUIS Peter Diederik Jan, HURLEY Dennis James, KADIYALA Irina Nikolaevna, KAUSHIK Ritu Rohit, KESHAVARZ SHOKRI Ali, KRAWIEC Mariusz, LEE Elaine Chungmin, LUISI Brian, MEDEK Ales, NUMA Mehdi, SHETH Urvi Jagdishbhai, SILINA Alina, VERWIJS Marinus Jacobus, YANG Xiaoqing, YOUNG Christopher Ryan, ZAMAN Noreen Tasneem, ZHANG Beili, ZHANG Yuegang, ZLOKARNIK Gregor, O BRIEN Jonathan P, October 27, 2011: WO/2011/133956 (5 worldwide citation)

The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using ...


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Tanoury Gerald J, Chen Minzhang, Jung Young Chun, Forslund Raymond E: Processes and intermediates for preparing steric compounds. Vertex Pharmaceuticals Incorporated, Tanoury Gerald J, Chen Minzhang, Jung Young Chun, Forslund Raymond E, O BRIEN Jonathan P, September 27, 2007: WO/2007/109023 (4 worldwide citation)

This invention relates to processes and intermediates for the preparation of an alpha- amino beta-hydroxy acid of Formula (1) wherein the variables R1 R’1 and R2 are defined herein and the compound of Formula (1) has an enantiomeric excess (ee) of 55% or greater.


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Huang Biying, Sun Ximei, Zhou Hongxia, Adamson George: Improved electrodes and electrochemical cells employing the same. Zpower, Huang Biying, Sun Ximei, Zhou Hongxia, Adamson George, O BRIEN Jonathan P, October 1, 2009: WO/2009/120352 (4 worldwide citation)

The present invention provides novel electrodes and electrochemical cells using these electrodes. Several embodiments presented by this invention provide novel cathodes that include an AgO active material and a PVDF binder. Furthermore, this invention also presents methods of manufacturing novel ele ...


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Goodwin Neal Clifford, Mc, Govren James Patrick: Cancer therapies and pharmaceutical compositions used therein. Pronai Therapeutics, Goodwin Neal Clifford, Mc, Govren James Patrick, O BRIEN Jonathan P, June 7, 2007: WO/2007/064945 (4 worldwide citation)

The invention relates to compositions and methods to inhibit gene expression. In particular, the invention provides co-therapies comprising oligonucleotides plus other therapies to treat cancer.


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RUAH SARA HADIDA S: Modulators of atp-binding cassette transporters. VERTEX PHARMACEUTICALS INCORPORATED, O Brien Jonathan P, May 14, 2010: WO/2010/053471 (4 worldwide citation)

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods o ...