1
Cottrell Kevin M, Maxwell John, Tang Qing, Grillot Anne Laure, Le, Tiran Arnaud, Perola Emanuele: Inhibitors of serine proteases. Vertex Pharmaceuticals Incorporated, Cottrell Kevin M, Maxwell John, Tang Qing, Grillot Anne Laure, Le, Tiran Arnaud, Perola Emanuele, O BRIEN Jonathan P, March 1, 2007: WO/2007/025307 (53 worldwide citation)

The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease.


2
Durand Reville Thomas, Jewell Charles, Hammond Charles, Chin Donovan: Irak modulators for treating an inflammatory condition, cell proliferative disorder, immune disorder. Biogen Idec Ma, Durand Reville Thomas, Jewell Charles, Hammond Charles, Chin Donovan, O BRIEN Jonathan P, March 13, 2008: WO/2008/030579 (30 worldwide citation)

The present invention relates to modulators of IRAK kinase and provides compositions comprising such modulators, as well as methods therewith for treating conditions or diseases mediated by or associated with IRAK kinase, such as rheumatoid arthitis, multiple sclerosis, sepsis, osteoarthrites, infla ...


3
Sun Lihong, Niu Deqiang, Shan Feng, Lee Wen Cherng, Feng Xiaomei: Spiro compounds as antagonists of tgf-beta. Biogen Idec Ma, Sun Lihong, Niu Deqiang, Shan Feng, Lee Wen Cherng, Feng Xiaomei, O BRIEN Jonathan P, January 15, 2009: WO/2009/009059 (29 worldwide citation)

The invention is related to compounds of formula (I) These compounds can be used as antagonists of the TGF-beta family tyle I receptors, Alk5 or Alk4. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such as fibrosis (e. g. renal fibrosis, pulmonary fibrosi ...


4
Lee Wen Cherng, Chuaqui Claudio, Sun Lihong, Hoemann Michael, Niu Deqiang, Yan Dingxue, Bonafoux Dominique, Cornebise Mark: Condensed imidazoles or pyrazoles and their use as transforming growth factor modulators. Biogen Idec Ma, Lee Wen Cherng, Chuaqui Claudio, Sun Lihong, Hoemann Michael, Niu Deqiang, Yan Dingxue, Bonafoux Dominique, Cornebise Mark, O BRIEN Jonathan P, July 5, 2007: WO/2007/076127 (29 worldwide citation)

The invention relates to compounds of formula I that are modulators of Transforming Growth Factor &bgr; (TGF &bgr;) and are useful for treating TGF &bgr; related diseases. In Formula (I) one of Rl or R2 is heteroaryl and the other is aryl or heteroaryl, one of Xl or X2 is C and the other is N.


5
Thorarensen Atli, Ruble Craig J, Fisher Jed F, Romero Donna L, Beauchamp Thomas J, Northuis Jill M: Antibacterial benzoic acid derivatives. Pharmacia & Upjohn Company, Thorarensen Atli, Ruble Craig J, Fisher Jed F, Romero Donna L, Beauchamp Thomas J, Northuis Jill M, O BRIEN Jonathan P, March 4, 2004: WO/2004/018428 (29 worldwide citation)

The invention provides antimicrobial agents and methods of using the agents for sterilization, sanitation, antisepsis, disinfection, and treatment of infections in mammals.


6
Ling Leona E, Fu Kai, Gill Alan, Gotwals Philip J: Methods of treating vascular injuries. Biogen Idec Ma, Ling Leona E, Fu Kai, Gill Alan, Gotwals Philip J, O BRIEN Jonathan P, April 27, 2006: WO/2006/044509 (28 worldwide citation)

The present invention relates to use of compounds and implantable devices including those compounds in treating, preventing, or reducing intimal thickening, vascular remodeling, restenosis (e.g., coronary, peripheral, carotid restenosis), vascular diseases, (e.g., organ transplant-related, cardiac, ...


7
Farmer Luc, Bethiel Randy Scott, Jacobs Dylan, Perni Robert B, Maxwell John, Cottrell Kevin, Halas Summer: Inhibitors of serine proteases. Vertex Pharmaceuticals Incorporated, Farmer Luc, Bethiel Randy Scott, Jacobs Dylan, Perni Robert B, Maxwell John, Cottrell Kevin, Halas Summer, O BRIEN Jonathan P, September 4, 2008: WO/2008/106058 (26 worldwide citation)

The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to ...


8
Lee Wen Cherng, Carter Mary Beth, Sun Lihong, Chuaqui Claudio, Singh Juswinder, Boriack Sjodin Paula, Choi Michael J: Imidazolopyridines and methods of making and using the same. Biogen Idec Ma, Lee Wen Cherng, Carter Mary Beth, Sun Lihong, Chuaqui Claudio, Singh Juswinder, Boriack Sjodin Paula, Choi Michael J, O BRIEN Jonathan P PhD, March 18, 2004: WO/2004/021989 (24 worldwide citation)

Compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I:


9
Lyons Steve, Perni Robert B: Inhibitors of serine proteases. Vertex Pharmaceuticals Incorporated, Lyons Steve, Perni Robert B, O BRIEN Jonathan P, February 8, 2007: WO/2007/016589 (22 worldwide citation)

This invention relates to compounds of formula (I): or a pharmaceutically acceptable salt or mixtures thereof wherein C* represents a diastereomeric carbon comprising a mixture of R and S isomers wherein the R isomer is greater than 50% of the mixture.


10
Makings Lewis R, Hurley Dennis J, Garcia Guzman, Blanco Miguel, Bergeron Daniele M, Nakatani Akiko: Modulators of muscarinic receptors. Vertex Pharmaceuticals Incorporated, Makings Lewis R, Hurley Dennis J, Garcia Guzman, Blanco Miguel, Bergeron Daniele M, Nakatani Akiko, O BRIEN Jonathan P, December 15, 2005: WO/2005/117883 (21 worldwide citation)

The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.