1
John W Boretos, Robert A Poirier: Aortic heart valve catheter. The United States of America represented by the Department of Health Education and Welfare, John S Roberts Jr, Norman J Latker, Thomas G Ferris, November 8, 1977: US04056854 (696 worldwide citation)

An artificial valve remotely placeable in a blood vessel without major surgery to supplant the function of a malfunctioning natural valve including an expansible check valve remotely placed in a constricted configuration through the vessel and a remotely removable constraint for selective expansion ...


2
P Demetrios Papahadjopoulos: Large unilamellar vesicles (LUV) and method of preparing same. The United States of America represented by the Secretary of Health Education and Welfare, John S Roberts Jr, Norman J Latker, Thomas G Ferris, March 7, 1978: US04078052 (82 worldwide citation)

A process and resulting product for producing large unilamellar phosphatidylserine vesicles (LUV) in the diameter of about 2,000-12,000 A which may additionally encapsulate a drug. The large vesicles are prepared from an initial phosphatidylserine aqueous solution which is subjected to ultrasound or ...


3
George M Thomas, John W Boretos, Donald C Syracuse, John A Clark, Anthony J Vita, Vincent A Gaudiani: Electrode for artificial pacemaker. The United States of America represented by the Secretary of Health Education and Welfare, John S Roberts Jr, Norman J Latker, Thomas G Ferris, September 12, 1978: US04112952 (64 worldwide citation)

An electrode for implantation in the heart to control atrio-ventricular block by artificial pacemaker including plural electrically conductive wires grouped in a bundle with spring metal arcuate prongs formed on one end thereof. A sheath is provided to compress the prongs for insertion of the electr ...


4
Robert M Chanock, Brian R Murphy: Temperature-sensitive recombinant mutant viruses and a process for producing same. The United States of America represented by the Department of Health Education and Welfare, John S Roberts Jr, Norman J Latker, Thomas G Ferris, November 16, 1976: US03992522 (47 worldwide citation)

A method and resulting temperature sensitive (ts) recombinants which may be produced by modifying wild-type influenza A viruses by utilization of chemically mutagenized donor viruses possessing ts lesions and shut off temperatures in the area 37.degree.-38.degree. C. Such a recombinant virus has bee ...


5
Glen R Gale, Paul Schwartz: Compound, 4-carboxyphthalato(1,2-diaminocyclohexane)-platinum(II) and alkali metal salts thereof. The United States of America represented by the Department of Health Education and Welfare, John S Roberts Jr, Norman J Latker, Thomas G Ferris, January 30, 1979: US04137248 (33 worldwide citation)

The Pt compound may be prepared by reacting the known dichloro(1,2-diaminocyclohexane)platinum(II) (NSC 194814) with silver nitrate to replace chloro with nitro. Subsequently, benzene tricarboxylic acid is added to form an off-white precipitate (2 hrs, dark, 5.degree. C) of the desired product which ...


6
Russell M Jaffe: Test for occult blood in an emulsified aqueous/organic system. The United States of America represented by the Secretary of the Department of Health Education and Welfare, John S Roberts Jr, Norman J Latker, Thomas G Ferris, July 12, 1977: US04035150 (28 worldwide citation)

A method and test of detecting occult blood in a stool or other physiologic fluid sample which offers novelty in that the reaction is carried out in the organic phase selected from the group consisting of methylene dichloride, petroleum ether, and dioxane in an aqueous/organic bi-phase system wherei ...


7
Leroy B Townsend, Arthur F Lewis, Linda W Roti Roti: Synthesis of 6-amino-4-methyl-8-(.beta.-D-ribofuranosyl)pyrrolo[4,3,2-de]pyrimido[4,5 -C]pyridazine-5-phosphate as a novel compound and its utility against L-1210 mouse leukemia. The United States of America represented by the Department of Health Education and Welfare, John S Roberts Jr, Norman J Latker, Thomas G Ferris, October 31, 1978: US04123524 (22 worldwide citation)

The compound 6-amino-4-methyl-8-(.beta.-D-ribofuranosyl)pyrrolo[4,3,2-de]pyrimido[4,5-c ]pyridazines-5'-phosphate (a nucleotide) as a new compound and its method of synthesis by phosphorylation of the known 6-amino-4-methyl-8-(.beta.-D-ribofuranosyl)pyrrolo[4,3,2-de]pyrimido[4,5-c ]pyridazine (a nuc ...


8
Henry Rapoport, Randy B Barber: Method of producing thebaine from codeine and oripavine from morphine. The United States of America represented by the Department of Health Education and Welfare, John S Roberts Jr, Norman J Latker, Thomas G Ferris, August 30, 1977: US04045440 (20 worldwide citation)

A method of producing thebaine from codeine and oripavine from morphine which comprises (a) producing the 0-6 methyl ethers from codeine and morphine using potassium hydride and methyl iodide as the O-alkylation agents and (b) subsequently oxidizing the respective 0-6 methyl ethers of codeine and mo ...


9
John A Beisler, Mohamed M Abbasi, John S Driscoll: Synthesis, structure, and antitumor activity of 5,6-dihydro-5-azacytidine. The United States of America represented by the Department of Health Education and Welfare, John S Roberts Jr, Norman J Latker, Thomas G Ferris, November 15, 1977: US04058602 (15 worldwide citation)

The compound 5,6-dihydro-5-azacytidine, 5AC[H], and non-toxic acid addition salts such as the hydrochloride, together with its preparation from 5-azacytidine (5-AC) by reduction of the 5,6-double bond of 5-AC with an alkali metal borohydride such as sodium borohydride. Additionally, 5,6-dihydro-5-az ...


10
Jerry G Spenney: Process for purifying iodinated bile acid conjugates. The United States of America represented by the Administrator of Veterans Affairs, Leon Zitver, Norman J Latker, Thomas G Ferris, June 10, 1980: US04207308 (14 worldwide citation)

Iodinatable bile salt derivatives are obtained by providing bile salts and their glycine and taurine conjugates with iodinatable groups. The radioiodinated compounds are useful in the radioimmunoassay of bile salts and in physiological studies. The preferred compound is cholylglycylhistamine. The sy ...