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Adam G Malofsky, Tanmoy Dey, Jeffrey M Sullivan, Yangbin Chen, Stanley C Wojciak, Bernard M Malofsky: Synthesis of methylene malonates substantially free of impurities. Bioformix, Edwards Wildman Palmer, Barry Kramer, Nicholas J DiCeglie Jr, December 17, 2013: US08609885 (39 worldwide citation)

The present invention provides improved methods for the chemical synthesis of methylene malonates using the Knovenagel synthesis reaction. The method of the invention provides for improved methylene malonates by significantly reducing or eliminating the formation of alternative and/or deleterious si ...


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Cristina Alonso Alija, Markus Heil, Dietmar Flubacher, Paul Naab, Johannes Peter Stasch, Frank Wunder, Klaus Dembowsky, Elisabeth Perzborn, Elke Stahl: Dicarboxylic acid derivatives with pharmaceutical properties. Bayer Aktiengesellschaft, Edwards Angell Palmer & Dodge, Nicholas J DiCeglie Jr, Mark D Russett, March 9, 2010: US07674825 (27 worldwide citation)

The present invention relates to the use of compounds of the formula (I) and to their salts and stereoisomers, for the preparation of medicaments for the treatment of cardiovascular disorders.


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Cristina Alonso Alija, Michael Harter, Michael Hahn, Josef Pernerstorfer, Stefan Weigand, Johannes Peter Stasch, Frank Wunder: Substituted aminodicarboxylic acid derivatives having pharmaceutical properties. Bayer Schering Pharma Aktiengesellschaft, Edwards Angell Palmer & Dodge, Nicholas J DiCeglie Jr, Barry Kramer, April 27, 2010: US07705043 (19 worldwide citation)

The invention relates to compounds of formula (I) and their salts and stereoisomers in which the variables are as defined in the description and claims, for producing medicaments used in the treatment of cardiovascular and other diseases. Such compounds, processes for preparing them, compositions co ...


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Martin Hendrix, Frank Gerhard Böβ, Christina Erb, Timo Fleβner, Marja van Kampen, Joachim Luithle, Christoph Methfessel, Welf Burkhard Wiese: 2-heteroarylcarboxylic acid amides. Bayer Schering Pharma Aktiengesellschaft, Edwards Angell Palmer & Dodge, Ralph A Loren, Nicholas J DiCeglie Jr, June 8, 2010: US07732477 (12 worldwide citation)

The invention relates to novel 2-heteroarylcarboxamides, processes for their preparation, and their use for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.


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Kazuaki Higuchi, Hideki Otsuki: Colloidal silica containing silica secondary particles having bent structure and/or branched structure, and method for producing same. Fuso Chemical, Edwards Wildman Palmer, James E Armstrong IV, Nicholas J DiCeglie Jr, September 10, 2013: US08529787 (10 worldwide citation)

This invention provides a dense, high-purity colloidal silica containing silica secondary particles having a branched and/or bent structure, and a production method thereof. Specifically, this invention provides a method for producing a colloidal silica, comprising the steps of 1) preparing a mother ...


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Tim Wharton, Hariprasad Gali, Michael R Hamblin: Photosensitizers for targeted photodynamic therapy. The General Hospital Corporation, Lynntech, Edwards Wildman Palmer, Peter C Lauro Esq, Nicholas J DiCeglie Jr Esq, June 26, 2012: US08207211 (10 worldwide citation)

The present invention relates to photosensitizer compounds based on functionalized fullerenes useful in targeted photodynamic therapy (PDT), and methods of use thereof.


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Ulrich Niewöhner, Maria Niewöhner legal representative, Mazen Es Sayed, Helmut Haning, Thomas Schenke, Karl Heinz Schlemmer, Jorg Keldenich, Erwin Bischoff, Elisabeth Perzborn, Klaus Dembowsky, Peter Serno, Marc Nowakowski: 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors. Bayer Schering Pharma Aktiengesellschaft, Edwards Angell Palmer & Dodge, Ralph A Loren, Nicholas J DiCeglie Jr, April 13, 2010: US07696206 (8 worldwide citation)

The application claims a compound of the formula or a salt, a hydrate, or a hydrate of a salt thereof. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of erectile dysfunction.


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Timo Fleβner, Frank Gerhard Böβ, Christina Erb, Frank Thorsten Hafner, Katrin Schnizler, Dieter Lang, Joachim Luithle, Marja Van Kampen, Franz Josef Van der Staay: Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists. Bayer Schering Pharma Aktiengesellschaft, Edwards Angell Palmer & Dodge, Ralph A Loren, Nicholas J DiCeglie Jr, September 14, 2010: US07795453 (8 worldwide citation)

The invention relates to novel benzothiophene-, benzofuran- and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.


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