1
Ramakrishnan Nagarajan, Amelia A Schabel: Novel glycopeptide derivatives. Eli Lilly and Company, Nancy J Harrison, Leroy Whitaker, October 6, 1987: US04698327 (84 worldwide citation)

Novel glycopeptide antibiotics of formula (I) can be prepared from the glycopeptide antibiotics vancomycin, A51568A, A51568B, M43A and M43D by reaction with a ketone or aldehyde followed, if appropriate, by reduction. The new glycopeptide derivatives are useful antibacterial agents.


2
Ramakrishnan Nagarajan, Amelia A Schabel: Modified glycopeptides. Eli Lilly and Company, Nancy J Harrison, February 17, 1987: US04643987 (50 worldwide citation)

Novel aracyl glycopeptide derivatives of formula 1 and methods for their preparation from the glycopeptide antibiotics vancomycin, A51568A, A51568B, M43A and M43D, are provided. The new glycopeptide derivatives are useful antibacterial agents.


3
LaVerne D Boeck, Hang Chio, Tom E Eaton, Otis W Godfrey Jr, Karl H Michel, Walter M Nakatsukasa, Raymond C Yao: Process for producing A83543 compounds. DowElanco, Andrea T Borucki, Nancy J Harrison, November 8, 1994: US05362634 (48 worldwide citation)

Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A983543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compou ...


4
Robert L Benefiel, John W Clarke, Dale C Harris, Robert J Morff, Peter L Oren: Delivery device for orally administered therapeutic agents. Eli Lilly and Company, Nancy J Harrison, Steven R Lammert, Leroy Whitaker, January 1, 1991: US04981468 (43 worldwide citation)

An improved device for containing and administering orally active therapeutic agents is described. A unit dose of a therapeutic agent in free-flowing form is retained and positioned for oral administration in a tube adapted to deliver the dose with a flow of liquid drawn through the tube by normal s ...


5
Manuel Debono: Derivatives of A-30912A nucleus. Eli Lilly and Company, Nancy J Harrison, Arthur R Whale, October 6, 1981: US04293489 (38 worldwide citation)

Compounds of the formula ##STR1## wherein R.sup.1 is a group of the formula: ##STR2## wherein A is divalent oxygen, sulfur, sulfinyl, or sulfonyl; A.sup.1 is divalent oxygen, sulfur, sulfinyl, sulfonyl or --NH--; X is hydrogen, chloro, bromo, iodo, nitro, C.sub.1 --C.sub.3 alkyl, hydroxy, C.sub.1 -C ...


6
Marvin M Hoehn, Karl H Michel: Antibiotic A-30912 and process for production thereof. Eli Lilly and Company, Nancy J Harrison, Arthur R Whale, May 17, 1977: US04024245 (36 worldwide citation)

Antibiotic A-30912 complex, comprising microbiologically active, structurally related factors A, B, C, D, E, F and G, is produced by submerged aerobic fermentation of Aspergillus rugulosus NRRL 8113. The A-30912 factors A, B, C, D, E, F, and G are separated from the A-30912 complex by chromatography ...


7
Manuel Debono, Herbert A Kirst: C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics. Eli Lilly and Company, Nancy J Harrison, Leroy Whitaker, April 11, 1989: US04820695 (34 worldwide citation)

C-20-Dihydro-deoxy-(cyclic amino)-derivatives of the macrolide antibiotics tylosin, desmycosin, macrocin, lactenocin, 2"'-O-demethylmacrocin and 2"-O-demethyllactenocin, which inhibit pathogenic bacteria, especially gram-positive bacteria, Pasteurella species, and Mycoplasma species, and pharmaceuti ...


8
Bernard J Abbott, Manuel Debono, David S Fukuda: A-21978C cyclic peptides. Eli Lilly and Company, Nancy J Harrison, Arthur R Whale, June 18, 1985: US04524135 (31 worldwide citation)

A-21978C cyclic peptides of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, an amino-protecting group , 8-methyldecanoyl, 10-methylundecanoyl, 10-methyldodecanoyl, the specific C.sub.10 -alkanoyl group of A-21978C factor C.sub.0 and the specific C.sub.12 -alkanoyl g ...


9
Bernard J Abbott, Manuel Debono, David S Fukuda: A-21978C cyclic peptides. Eli Lilly and Company, Nancy J Harrison, Arthur R Whale, November 13, 1984: US04482487 (30 worldwide citation)

A-21978C cyclic peptides of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, an amino-protecting group, 8-methyldecanoyl, 10-methylundecanoyl, 10-methyldodecanoyl, the specific C.sub.10 -alkanoyl group of A-21978C factor C.sub.0 and the specific C.sub.12 -alkanoyl gr ...


10
Calvin E Higgens, Karl H Michel: Antibiotic A-22082 and process for production thereof. Eli Lilly and Company, Nancy J Harrison, Arthur R Whale, May 17, 1977: US04024246 (30 worldwide citation)

Antibiotic A-22082 is produced by submerged aerobic fermentation of Aspergillus nidulans NRRL 8112. Antibiotic A-22082 is an antifungal agent.