1
Anthony L Kuczynski, Jerry D Childers, Glen E Barclay, Susan Rodriguez, Sonya Merrill: Composition and dosage form comprising opioid antagonist. ALZA Corporation, Paul Sabatine, Susan K Thomas, Michael J Rafa, February 2, 1999: US05866164 (217 worldwide citation)

A composition of matter is disclosed and claimed comprising an opioid antagonist and a high molecular weight poly(alkylene) or a poly(carboxymethylcellulose). A dosage form is disclosed and claimed comprising the composition of matter for displacing an opioid analgesic from the dosage form.


2
Jeffry G Weers, Ernest G Schutt, Luis A Dellamary, Thomas E Tarara, Alexey Kabalnov: Stabilized preparations for use in metered dose inhalers. Inhale Therapeutic Systems, Michael J Rafa, Felissa H Cagan, October 30, 2001: US06309623 (114 worldwide citation)

Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a hydrofluoroalkane propellant. As density variatio ...


3
Thomas E Tarara, Jeffry G Weers, Alexey Kabalnov, Ernest G Schutt, Luis A Dellamary: Methods of spray drying pharmaceutical compositions. Inhale Therapeutic Systems, Michael J Rafa, Felissa H Cagan, May 20, 2003: US06565885 (112 worldwide citation)

Spray drying methods for forming powder compositions for pharmaceutical applications are disclosed. According to one aspect of the invention, the spray drying feed stock comprises a bioactive agent, surfactant, and a blowing agent. Another aspect of the invention is directed to spray drying a feed s ...


4
Robert M Platz, Thomas K Brewer, Terence D Boardman: Dispersible macromolecule compositions and methods for their preparation and use. Inhale Therapeutic Systems, Michael J Rafa, Felissa H Cagan, July 15, 2003: US06592904 (97 worldwide citation)

A process for preparing ultrafine powders of biological macromolecules comprises atomizing liquid solutions of the macromolecules, drying the droplets formed in the atomization step, and collecting the particles which result from drying. By properly controlling each of the atomization, drying, and c ...


5
Robert M Platz, Thomas K Brewer, Terence D Boardman: Dispersible macromolecule compositions and methods for their preparation and use. Inhale Therapeutic Systems, Michael J Rafa, Felissa H Cagan, July 23, 2002: US06423344 (96 worldwide citation)

A process for preparing ultrafine powders of biological macromolecules comprises atomizing liquid solutions of the macromolecules, drying the droplets formed in the atomization step, and collecting the particles which result from drying. By properly controlling each of the atomization, drying, and c ...


6
Jerry D Childers, George V Guittard, Glen E Barclay, Anthony L Kuczynski, Patrick S L Wong: Hydrocodone therapy. ALZA Corporation, Paul Sabatine, Susan K Thomas, Michael J Rafa, February 2, 1999: US05866161 (84 worldwide citation)

A hydrocodone composition, a hydrocodone dosage form, and a method of administering hydrocodone are disclosed and indicated for hydrocodone therapy.


7
Patrick S L Wong, Felix Theeuwes, George V Guittard, Atul D Ayer: Method of therapy comprising an osmotic caplet. Alza Corporation, Paul L Sabatine, Susan K Thomas, Michael J Rafa, February 9, 1999: US05869097 (79 worldwide citation)

An osmotic caplet is disclosed comprising an osmotic caplet exit for delivering a preselected dose of drug to a patient in need of therapy.


8
Sonya Merrill, Atul D Ayer, Navjot Chadha, Anthony L Kuczynski: Hydromorphone therapy. ALZA Corporation, Paul L Sabatine, Michael J Rafa, Susan K Thomas, June 22, 1999: US05914131 (73 worldwide citation)

A hydromorphone composition, a hydromorphone dosage form and a method for administering hydromorphone are disclosed, indicated for the management of pain.


9
Sonya Merrill, Atul Devdatt Ayer, Paul Hwang, Anthony L Kuczynski: Morphine therapy. Alza Corporation, Paul L Sabatine, Mary Ann Dillahunty, Michael J Rafa, September 16, 1997: US05667805 (70 worldwide citation)

A composition comprising morphine; and a dosage form comprising morphine are disclosed for morphine therapy. A method of using the composition and the dosage form are disclosed and indicated for morphine therapy.


10
Sonya Merrill, Atul D Ayer, Paul M Hwang, Anthony L Kuczynski, Nils W Ahlgren, Deborah J Johnson: Compositions containing opiate analgesics. Alza Corporation, Paul L Sabatine, Susan K Thomas, Michael J Rafa, September 7, 1999: US05948787 (67 worldwide citation)

An opiate analgesic composition and a non-opiate analgesic composition are disclosed for delivering an analgesic in either embodiment to a patient in need of relief from pain. The analgesics are present optionally with a nonionic surfactant and with an osmotic composition comprising a carbonate or b ...